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• W2783293907 abstract "Two pairs of new diarylheptanoid-monoterpene adduct enantiomers, (±)-alpininoids A and B [(±)-1 and (±)-2], as well as three pairs of new diarylheptanoid-sesquiterpene adduct enantiomers, (±)-alpininoids C-E [(±)-3-(±)-5], together with four known diarylheptanoids (6-9) were isolated from the rhizomes of Alpinia officinarum. Their structures with absolute configurations were elucidated on the basis of comprehensive spectroscopic analyses and computational calculation methods. The skeletons of these cyclohexene-containing hybrid natural products were hypothesized to be generated via a crucial Diels-Alder cycloaddition between the diarylheptanoids (7 and 8) and terpenes, of which 1 represents a new carbon skeleton. All isolated compounds were evaluated for their neuroprotective effects against MPP+ (1-methyl-4-phenylpyridinium)-induced cortical neuron injury. At a concentration of 16 μM, (+)-1 significantly increased cell viability when compared with MPP+ treatment alone." @default.
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• W2783293907 date "2018-01-11" @default.
• W2783293907 modified "2023-10-11" @default.
• W2783293907 title "Evaluation of Diarylheptanoid–Terpene Adduct Enantiomers from <i>Alpinia officinarum</i> for Neuroprotective Activities" @default.
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• W2783293907 doi "https://doi.org/10.1021/acs.jnatprod.7b00803" @default.
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