FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783295659> ?p ?o ?g. }

• W2783295659 endingPage "788" @default.
• W2783295659 startingPage "774" @default.
• W2783295659 abstract "Parkinson's disease is characterized by the loss of dopamine (DA) neurons in the substantia nigra pars compacta (SNc). DA neurons in the ventral tegmental area are more resistant to this degeneration than those in the SNc, though the mechanisms for selective resistance or vulnerability remain poorly understood. A key to elucidating these processes may lie within the subset of DA neurons that corelease glutamate and express the vesicular glutamate transporter VGLUT2. Here, we addressed the potential relationship between VGLUT expression and DA neuronal vulnerability by overexpressing VGLUT in DA neurons of flies and mice. In Drosophila, VGLUT overexpression led to loss of select DA neuron populations. Similarly, expression of VGLUT2 specifically in murine SNc DA neurons led to neuronal loss and Parkinsonian behaviors. Other neuronal cell types showed no such sensitivity, suggesting that DA neurons are distinctively vulnerable to VGLUT2 expression. Additionally, most DA neurons expressed VGLUT2 during development, and coexpression of VGLUT2 with DA markers increased following injury in the adult. Finally, conditional deletion of VGLUT2 made DA neurons more susceptible to Parkinsonian neurotoxins. These data suggest that the balance of VGLUT2 expression is a crucial determinant of DA neuron survival. Ultimately, manipulation of this VGLUT2-dependent process may represent an avenue for therapeutic development." @default.
• W2783295659 created "2018-01-26" @default.
• W2783295659 creator A5009770092 @default.
• W2783295659 creator A5013611528 @default.
• W2783295659 creator A5013792187 @default.
• W2783295659 creator A5025583603 @default.
• W2783295659 creator A5033725103 @default.
• W2783295659 creator A5034351718 @default.
• W2783295659 creator A5035939534 @default.
• W2783295659 creator A5057571524 @default.
• W2783295659 creator A5085144166 @default.
• W2783295659 creator A5088867610 @default.
• W2783295659 date "2018-01-16" @default.
• W2783295659 modified "2023-10-17" @default.
• W2783295659 title "Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons" @default.
• W2783295659 cites W1491963713 @default.
• W2783295659 cites W1522510037 @default.
• W2783295659 cites W1582986153 @default.
• W2783295659 cites W1931774077 @default.
• W2783295659 cites W1966282260 @default.
• W2783295659 cites W1967659552 @default.
• W2783295659 cites W1968522541 @default.
• W2783295659 cites W1974898145 @default.
• W2783295659 cites W1976316003 @default.
• W2783295659 cites W1980949515 @default.
• W2783295659 cites W1988299561 @default.
• W2783295659 cites W1988499718 @default.
• W2783295659 cites W1991486160 @default.
• W2783295659 cites W1995111140 @default.
• W2783295659 cites W1998650202 @default.
• W2783295659 cites W1999032208 @default.
• W2783295659 cites W2003367821 @default.
• W2783295659 cites W2003949705 @default.
• W2783295659 cites W2004002023 @default.
• W2783295659 cites W2010408327 @default.
• W2783295659 cites W2016293036 @default.
• W2783295659 cites W2022911097 @default.
• W2783295659 cites W2023713359 @default.
• W2783295659 cites W2027956648 @default.
• W2783295659 cites W2030536065 @default.
• W2783295659 cites W2032541433 @default.
• W2783295659 cites W2037500812 @default.
• W2783295659 cites W2038505488 @default.
• W2783295659 cites W2038825302 @default.
• W2783295659 cites W2046793491 @default.
• W2783295659 cites W2052323454 @default.
• W2783295659 cites W2054421268 @default.
• W2783295659 cites W2068075585 @default.
• W2783295659 cites W2079497700 @default.
• W2783295659 cites W2080458091 @default.
• W2783295659 cites W2088599563 @default.
• W2783295659 cites W2090285005 @default.
• W2783295659 cites W2091041795 @default.
• W2783295659 cites W2097708062 @default.
• W2783295659 cites W2104135721 @default.
• W2783295659 cites W2104827963 @default.
• W2783295659 cites W2109326232 @default.
• W2783295659 cites W2109604162 @default.
• W2783295659 cites W2110665798 @default.
• W2783295659 cites W2114395128 @default.
• W2783295659 cites W2121527315 @default.
• W2783295659 cites W2127187175 @default.
• W2783295659 cites W2134886133 @default.
• W2783295659 cites W2135342911 @default.
• W2783295659 cites W2135710940 @default.
• W2783295659 cites W2136916973 @default.
• W2783295659 cites W2139495058 @default.
• W2783295659 cites W2141196699 @default.
• W2783295659 cites W2148214085 @default.
• W2783295659 cites W2153213393 @default.
• W2783295659 cites W2186909533 @default.
• W2783295659 cites W2200183975 @default.
• W2783295659 cites W2304380155 @default.
• W2783295659 cites W2400163830 @default.
• W2783295659 cites W2419550169 @default.
• W2783295659 cites W2490787055 @default.
• W2783295659 cites W2567343056 @default.
• W2783295659 cites W2571740089 @default.
• W2783295659 cites W2588863214 @default.
• W2783295659 cites W2595455544 @default.
• W2783295659 cites W2596524877 @default.
• W2783295659 cites W2748985090 @default.
• W2783295659 cites W62603772 @default.
• W2783295659 doi "https://doi.org/10.1172/jci95795" @default.
• W2783295659 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5785252" @default.
• W2783295659 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29337309" @default.
• W2783295659 hasPublicationYear "2018" @default.
• W2783295659 type Work @default.
• W2783295659 sameAs 2783295659 @default.
• W2783295659 citedByCount "65" @default.
• W2783295659 countsByYear W27832956592018 @default.
• W2783295659 countsByYear W27832956592019 @default.
• W2783295659 countsByYear W27832956592020 @default.
• W2783295659 countsByYear W27832956592021 @default.
• W2783295659 countsByYear W27832956592022 @default.
• W2783295659 countsByYear W27832956592023 @default.
• W2783295659 crossrefType "journal-article" @default.
• W2783295659 hasAuthorship W2783295659A5009770092 @default.

• next