Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783298249> ?p ?o ?g. }
- W2783298249 abstract "Development of remote stimulation techniques for neuronal tissues represents a challenging goal. Among the potential methods, mechanical stimuli are the most promising vector to convey information non-invasively into intact brain tissue. In this context, selective mechano-sensitization of neuronal circuits would pave the way to develop a new cell-type specific stimulation approach. We report here for the first time the development and characterization of mechano-sensitized neuronal networks through the heterologous expression of an engineered bacterial large conductance mechanosensitive ion channel (MscL). The neuronal functional expression of the MscL channel was validated through patch-clamp recordings upon application of calibrated suction pressures. Moreover, we verified the effective development of in-vitro neuronal networks expressing the engineered MscL channel in terms of cell survival, number of synaptic puncta, and spontaneous network activity. The pure mechanosensitivity of the engineered MscL channel, with its wide genetic modification library, may represent a versatile tool to further develop a mechano-genetic approach." @default.
- W2783298249 created "2018-01-26" @default.
- W2783298249 creator A5007053275 @default.
- W2783298249 creator A5020342643 @default.
- W2783298249 creator A5033037664 @default.
- W2783298249 creator A5044451146 @default.
- W2783298249 creator A5047767005 @default.
- W2783298249 creator A5051437683 @default.
- W2783298249 creator A5051794203 @default.
- W2783298249 creator A5056497666 @default.
- W2783298249 creator A5083500458 @default.
- W2783298249 creator A5087727220 @default.
- W2783298249 date "2018-01-01" @default.
- W2783298249 modified "2023-10-17" @default.
- W2783298249 title "Mechano-sensitization of mammalian neuronal networks through expression of the bacterial mechanosensitive MscL channel" @default.
- W2783298249 cites W1966403223 @default.
- W2783298249 cites W1968169427 @default.
- W2783298249 cites W1968831293 @default.
- W2783298249 cites W1972130450 @default.
- W2783298249 cites W1978171511 @default.
- W2783298249 cites W1991018243 @default.
- W2783298249 cites W1995260313 @default.
- W2783298249 cites W2006192648 @default.
- W2783298249 cites W2007168806 @default.
- W2783298249 cites W2010717774 @default.
- W2783298249 cites W2010838940 @default.
- W2783298249 cites W2011750425 @default.
- W2783298249 cites W2014840564 @default.
- W2783298249 cites W2015026123 @default.
- W2783298249 cites W2018169865 @default.
- W2783298249 cites W2023405416 @default.
- W2783298249 cites W2024659665 @default.
- W2783298249 cites W2036145275 @default.
- W2783298249 cites W2045540516 @default.
- W2783298249 cites W2048807539 @default.
- W2783298249 cites W2056731994 @default.
- W2783298249 cites W2058309529 @default.
- W2783298249 cites W2077207596 @default.
- W2783298249 cites W2089845241 @default.
- W2783298249 cites W2092415707 @default.
- W2783298249 cites W2094978799 @default.
- W2783298249 cites W2102978118 @default.
- W2783298249 cites W2103253964 @default.
- W2783298249 cites W2108156300 @default.
- W2783298249 cites W2108846059 @default.
- W2783298249 cites W2109466522 @default.
- W2783298249 cites W2115175648 @default.
- W2783298249 cites W2118756387 @default.
- W2783298249 cites W2125782175 @default.
- W2783298249 cites W2126319786 @default.
- W2783298249 cites W2127780691 @default.
- W2783298249 cites W2127882138 @default.
- W2783298249 cites W2149350207 @default.
- W2783298249 cites W2150089843 @default.
- W2783298249 cites W2158093415 @default.
- W2783298249 cites W2159760243 @default.
- W2783298249 cites W2166599924 @default.
- W2783298249 cites W2262412919 @default.
- W2783298249 cites W2271885288 @default.
- W2783298249 cites W2274428315 @default.
- W2783298249 cites W2294690275 @default.
- W2783298249 cites W2301046551 @default.
- W2783298249 cites W2301678655 @default.
- W2783298249 cites W2342931385 @default.
- W2783298249 cites W2394488676 @default.
- W2783298249 cites W2399670039 @default.
- W2783298249 cites W2411120473 @default.
- W2783298249 cites W2482028863 @default.
- W2783298249 cites W2484894497 @default.
- W2783298249 cites W2522174175 @default.
- W2783298249 cites W2537854223 @default.
- W2783298249 cites W2573958866 @default.
- W2783298249 cites W2575878849 @default.
- W2783298249 cites W2587049423 @default.
- W2783298249 cites W2599065202 @default.
- W2783298249 cites W2606119932 @default.
- W2783298249 cites W2620619632 @default.
- W2783298249 cites W2624351657 @default.
- W2783298249 cites W2731130386 @default.
- W2783298249 cites W2743063852 @default.
- W2783298249 cites W2771503729 @default.
- W2783298249 doi "https://doi.org/10.1242/jcs.210393" @default.
- W2783298249 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5897719" @default.
- W2783298249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29361543" @default.
- W2783298249 hasPublicationYear "2018" @default.
- W2783298249 type Work @default.
- W2783298249 sameAs 2783298249 @default.
- W2783298249 citedByCount "13" @default.
- W2783298249 countsByYear W27832982492018 @default.
- W2783298249 countsByYear W27832982492019 @default.
- W2783298249 countsByYear W27832982492020 @default.
- W2783298249 countsByYear W27832982492021 @default.
- W2783298249 countsByYear W27832982492022 @default.
- W2783298249 countsByYear W27832982492023 @default.
- W2783298249 crossrefType "journal-article" @default.
- W2783298249 hasAuthorship W2783298249A5007053275 @default.
- W2783298249 hasAuthorship W2783298249A5020342643 @default.
- W2783298249 hasAuthorship W2783298249A5033037664 @default.
- W2783298249 hasAuthorship W2783298249A5044451146 @default.
- W2783298249 hasAuthorship W2783298249A5047767005 @default.