Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783302606> ?p ?o ?g. }
- W2783302606 abstract "Behavioral studies demonstrated that the administration of Withania somnifera Dunal roots extract (WSE), prolongs morphine-elicited analgesia and reduces the development of tolerance to the morphine’s analgesic effect; however, little is known about the underpinning molecular mechanism(s). In order to shed light on this issue in the present paper we explored whether WSE promotes alterations of μ (MOP) and nociceptin (NOP) opioid receptors gene expression in neuroblastoma SH-SY5Y cells. A range of WSE concentrations was preliminarily tested to evaluate their effects on cell viability. Subsequently, the effects of 5 h exposure to WSE (0.25, 0.50 and 1.00 mg/ml), applied alone and in combination with morphine or naloxone, on MOP and NOP mRNA levels were investigated. Data analysis revealed that morphine decreased MOP and NOP receptor gene expression, whereas naloxone elicited their up-regulation. In addition, pre-treatment with naloxone prevented the morphine-elicited gene expression alterations. Interestingly, WSE was able to: a) alter MOP but not NOP gene expression; b) counteract, at its highest concentration, morphine-induced MOP down-regulation, and c) hamper naloxone-induced MOP and NOP up-regulation. Present in-vitro data disclose novel evidence about the ability of WSE to influence MOP and NOP opioid receptors gene expression in SH-SY5Y cells. Moreover, our findings suggest that the in-vivo modulation of morphine-mediated analgesia by WSE could be related to the hindering of morphine-elicited opioid receptors down-regulation here observed following WSE pre-treatment at its highest concentration." @default.
- W2783302606 created "2018-01-26" @default.
- W2783302606 creator A5011745663 @default.
- W2783302606 creator A5017229105 @default.
- W2783302606 creator A5024452017 @default.
- W2783302606 creator A5025307452 @default.
- W2783302606 creator A5068287261 @default.
- W2783302606 creator A5078562133 @default.
- W2783302606 date "2018-01-10" @default.
- W2783302606 modified "2023-09-24" @default.
- W2783302606 title "The standardized Withania somnifera Dunal root extract alters basal and morphine-induced opioid receptor gene expression changes in neuroblastoma cells" @default.
- W2783302606 cites W1499500424 @default.
- W2783302606 cites W181662175 @default.
- W2783302606 cites W1829332936 @default.
- W2783302606 cites W1890836171 @default.
- W2783302606 cites W1948424572 @default.
- W2783302606 cites W1964705194 @default.
- W2783302606 cites W1970092573 @default.
- W2783302606 cites W1971126800 @default.
- W2783302606 cites W1971385873 @default.
- W2783302606 cites W1981602327 @default.
- W2783302606 cites W1985178609 @default.
- W2783302606 cites W1991933561 @default.
- W2783302606 cites W1992413291 @default.
- W2783302606 cites W2003424600 @default.
- W2783302606 cites W2016237474 @default.
- W2783302606 cites W2017788930 @default.
- W2783302606 cites W2018652969 @default.
- W2783302606 cites W2018910234 @default.
- W2783302606 cites W2019500797 @default.
- W2783302606 cites W2023527659 @default.
- W2783302606 cites W2025030241 @default.
- W2783302606 cites W2036608792 @default.
- W2783302606 cites W2037441124 @default.
- W2783302606 cites W2042526378 @default.
- W2783302606 cites W2043563630 @default.
- W2783302606 cites W2043606739 @default.
- W2783302606 cites W2048283799 @default.
- W2783302606 cites W2060353353 @default.
- W2783302606 cites W2063331328 @default.
- W2783302606 cites W2067932965 @default.
- W2783302606 cites W2082552678 @default.
- W2783302606 cites W2085213284 @default.
- W2783302606 cites W2095421854 @default.
- W2783302606 cites W2096489825 @default.
- W2783302606 cites W2099367229 @default.
- W2783302606 cites W2100258320 @default.
- W2783302606 cites W2102845038 @default.
- W2783302606 cites W2107277218 @default.
- W2783302606 cites W2113565950 @default.
- W2783302606 cites W2114918609 @default.
- W2783302606 cites W2121680389 @default.
- W2783302606 cites W2122053103 @default.
- W2783302606 cites W2129146027 @default.
- W2783302606 cites W2129664426 @default.
- W2783302606 cites W2137964312 @default.
- W2783302606 cites W2140031385 @default.
- W2783302606 cites W2141833903 @default.
- W2783302606 cites W2142340920 @default.
- W2783302606 cites W2144084200 @default.
- W2783302606 cites W2155715632 @default.
- W2783302606 cites W2157999436 @default.
- W2783302606 cites W2164176196 @default.
- W2783302606 cites W2166179072 @default.
- W2783302606 cites W2170948133 @default.
- W2783302606 cites W2183943753 @default.
- W2783302606 cites W2192080449 @default.
- W2783302606 cites W2255620943 @default.
- W2783302606 cites W2278601039 @default.
- W2783302606 cites W2304450774 @default.
- W2783302606 cites W2316583775 @default.
- W2783302606 cites W2589834961 @default.
- W2783302606 cites W896717243 @default.
- W2783302606 doi "https://doi.org/10.1186/s12906-017-2065-9" @default.
- W2783302606 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5761194" @default.
- W2783302606 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29316911" @default.
- W2783302606 hasPublicationYear "2018" @default.
- W2783302606 type Work @default.
- W2783302606 sameAs 2783302606 @default.
- W2783302606 citedByCount "13" @default.
- W2783302606 countsByYear W27833026062018 @default.
- W2783302606 countsByYear W27833026062019 @default.
- W2783302606 countsByYear W27833026062020 @default.
- W2783302606 countsByYear W27833026062021 @default.
- W2783302606 countsByYear W27833026062022 @default.
- W2783302606 countsByYear W27833026062023 @default.
- W2783302606 crossrefType "journal-article" @default.
- W2783302606 hasAuthorship W2783302606A5011745663 @default.
- W2783302606 hasAuthorship W2783302606A5017229105 @default.
- W2783302606 hasAuthorship W2783302606A5024452017 @default.
- W2783302606 hasAuthorship W2783302606A5025307452 @default.
- W2783302606 hasAuthorship W2783302606A5068287261 @default.
- W2783302606 hasAuthorship W2783302606A5078562133 @default.
- W2783302606 hasBestOaLocation W27833026061 @default.
- W2783302606 hasConcept C104317684 @default.
- W2783302606 hasConcept C125439840 @default.
- W2783302606 hasConcept C126322002 @default.
- W2783302606 hasConcept C142724271 @default.
- W2783302606 hasConcept C14397066 @default.
- W2783302606 hasConcept C150194340 @default.