Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783370725> ?p ?o ?g. }
- W2783370725 abstract "Malignant mesothelioma (MM) is poorly responsive to systemic cytotoxic chemotherapy and invariably fatal. Here we describe a screen of 94 drugs in 15 exome-sequenced MM lines and the discovery of a subset defined by loss of function of the nuclear deubiquitinase BRCA associated protein-1 (BAP1) that demonstrate heightened sensitivity to TRAIL (tumour necrosis factor-related apoptosis-inducing ligand). This association is observed across human early passage MM cultures, mouse xenografts and human tumour explants. We demonstrate that BAP1 deubiquitinase activity and its association with ASXL1 to form the Polycomb repressive deubiquitinase complex (PR-DUB) impacts TRAIL sensitivity implicating transcriptional modulation as an underlying mechanism. Death receptor agonists are well-tolerated anti-cancer agents demonstrating limited therapeutic benefit in trials without a targeting biomarker. We identify BAP1 loss-of-function mutations, which are frequent in MM, as a potential genomic stratification tool for TRAIL sensitivity with immediate and actionable therapeutic implications." @default.
- W2783370725 created "2018-01-26" @default.
- W2783370725 creator A5005600169 @default.
- W2783370725 creator A5007430977 @default.
- W2783370725 creator A5011181919 @default.
- W2783370725 creator A5011417005 @default.
- W2783370725 creator A5012779200 @default.
- W2783370725 creator A5014964963 @default.
- W2783370725 creator A5015496797 @default.
- W2783370725 creator A5015673151 @default.
- W2783370725 creator A5019757898 @default.
- W2783370725 creator A5020129085 @default.
- W2783370725 creator A5022864309 @default.
- W2783370725 creator A5026282050 @default.
- W2783370725 creator A5030815513 @default.
- W2783370725 creator A5033987963 @default.
- W2783370725 creator A5035853076 @default.
- W2783370725 creator A5036171216 @default.
- W2783370725 creator A5038603236 @default.
- W2783370725 creator A5041788878 @default.
- W2783370725 creator A5052065997 @default.
- W2783370725 creator A5053073617 @default.
- W2783370725 creator A5053447918 @default.
- W2783370725 creator A5054800980 @default.
- W2783370725 creator A5057913884 @default.
- W2783370725 creator A5062257210 @default.
- W2783370725 creator A5064561541 @default.
- W2783370725 creator A5067097797 @default.
- W2783370725 creator A5079365516 @default.
- W2783370725 creator A5080415325 @default.
- W2783370725 creator A5084431909 @default.
- W2783370725 creator A5085472676 @default.
- W2783370725 creator A5085552716 @default.
- W2783370725 date "2018-01-18" @default.
- W2783370725 modified "2023-10-14" @default.
- W2783370725 title "Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells" @default.
- W2783370725 cites W1527082451 @default.
- W2783370725 cites W1972473939 @default.
- W2783370725 cites W1973904343 @default.
- W2783370725 cites W1975807921 @default.
- W2783370725 cites W1979946545 @default.
- W2783370725 cites W1981733870 @default.
- W2783370725 cites W1986302429 @default.
- W2783370725 cites W1989561383 @default.
- W2783370725 cites W1999813105 @default.
- W2783370725 cites W2004620466 @default.
- W2783370725 cites W2006752813 @default.
- W2783370725 cites W2007265317 @default.
- W2783370725 cites W2017932620 @default.
- W2783370725 cites W2043696829 @default.
- W2783370725 cites W2056217426 @default.
- W2783370725 cites W2057802075 @default.
- W2783370725 cites W2059150400 @default.
- W2783370725 cites W2062351247 @default.
- W2783370725 cites W2070195376 @default.
- W2783370725 cites W2073904860 @default.
- W2783370725 cites W2077182892 @default.
- W2783370725 cites W2085531754 @default.
- W2783370725 cites W2092524729 @default.
- W2783370725 cites W2092892924 @default.
- W2783370725 cites W2102627969 @default.
- W2783370725 cites W2106284224 @default.
- W2783370725 cites W2107268345 @default.
- W2783370725 cites W2108196925 @default.
- W2783370725 cites W2108902725 @default.
- W2783370725 cites W2109972881 @default.
- W2783370725 cites W2110687686 @default.
- W2783370725 cites W2113035823 @default.
- W2783370725 cites W2114024085 @default.
- W2783370725 cites W2118151336 @default.
- W2783370725 cites W2125789330 @default.
- W2783370725 cites W2130988210 @default.
- W2783370725 cites W2133221875 @default.
- W2783370725 cites W2142769937 @default.
- W2783370725 cites W2149063105 @default.
- W2783370725 cites W2149883217 @default.
- W2783370725 cites W2154397429 @default.
- W2783370725 cites W2156330379 @default.
- W2783370725 cites W2171139000 @default.
- W2783370725 cites W2174169141 @default.
- W2783370725 cites W2176258152 @default.
- W2783370725 cites W2258553021 @default.
- W2783370725 cites W2291531085 @default.
- W2783370725 cites W2539599065 @default.
- W2783370725 cites W2620490360 @default.
- W2783370725 doi "https://doi.org/10.7554/elife.30224" @default.
- W2783370725 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5773178" @default.
- W2783370725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29345617" @default.
- W2783370725 hasPublicationYear "2018" @default.
- W2783370725 type Work @default.
- W2783370725 sameAs 2783370725 @default.
- W2783370725 citedByCount "20" @default.
- W2783370725 countsByYear W27833707252018 @default.
- W2783370725 countsByYear W27833707252019 @default.
- W2783370725 countsByYear W27833707252020 @default.
- W2783370725 countsByYear W27833707252021 @default.
- W2783370725 countsByYear W27833707252022 @default.
- W2783370725 countsByYear W27833707252023 @default.
- W2783370725 crossrefType "journal-article" @default.
- W2783370725 hasAuthorship W2783370725A5005600169 @default.