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• W2783402787 abstract "Abstract Ifosfamide ( IFA ) is a potent alkylating antitumoral agent, but its use is limited by neurological side effects. IFA is a racemic mixture of two enantiomeric forms, R ‐ IFA and S ‐ IFA with a stereoselective metabolism by CYP 3A4 and CYP 2B6, leading either to bioactive or to toxic pathways. In three consecutive cases of pediatric patients who exhibited IFA‐induced encephalopathy ( IIE ), genotyping of clinically relevant single‐nucleotide polymorphisms associated with decreased CYP 3A4 and CYP 2B6 activities was performed. Genetic investigations revealed the presence of CYP 2B6 rs4803419 (C>T) in one patient while the two others carried the CYP 2B6*6 allelic variant. All patients carried CYP 3A4 wild‐type genotype ( CYP 3A4*1/*1 ). Because CYP 2B6‐deficient alleles may be responsible for an increased conversion of S ‐ IFA into neurotoxic metabolites, screening for CYP 2B6 polymorphisms may help to avoid IIE and improve clinical outcomes." @default.
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• W2783402787 date "2018-01-25" @default.
• W2783402787 modified "2023-10-17" @default.
• W2783402787 title "Possible role of<i>CYP2B6</i>genetic polymorphisms in ifosfamide-induced encephalopathy: report of three cases" @default.
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• W2783402787 doi "https://doi.org/10.1111/fcp.12345" @default.
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