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- W2783403645 abstract "In present investigation an attempt has been made to design and develop someGliclazide matrix tablets using Hydroxy propyl cellulose, Hydroxy propyl methylcellulose and their combination as release retarding polymers. Gliclazide is oralhypoglycaemic drug which lowers blood glucose level and has been selected toprepare sustained release dosage forms.Gliclazide sustained release matrix tablets were prepared using Hydorxy PropylCellulose, Hydroxy Propyl Methyl Cellulose and their combination as base polymerby wet granulation method. FT-IR spectral analysis showed that characteristic peak ofGliclazide pure drug was retained in the spectra of all the formulations indicating theinactness of the drug in all the formulations. The prepared tablets were evaluated fornumber of parameters like thickness, diameter, weight variation, swelling index and invitro release studies. All the prepared tablets were of smooth surface and eleganttexture. The tablets prepared were checked visually for its appearance & surfacetexture. The weights of the tablets were in the range of 250 ± 5 mg. The thickness ofthe tablet was in the range of 4.45 ± 0.11 mm to 4.51 ± 0.12 mmGliclazide matrix tablets formulated employing HPMC K-4M andcombination of HPMC K-4M and HPC 75-100 provided slow and controlled releaseof Gliclazide up to 12 hr.Drug release from the matrix tablets formulation containing HPMC K-4M and HPC75-100 follows first order drug release with non-fickian diffusion.All the tablet formulation showed compliance with pharmacopoeial standard.As the time increases, the swelling index was increased; later on it decreases Gradually due to dissolution of outermost –gelled layer of tablet intodissolution medium. Comparison between HPMC K-4M, HPC 75-100 and theircombination it has been observed that swelling index of HPMC K-4M wassignificantly more compared to HPC 75-100. Whereas swelling index in case ofHPC 75-100 is less as compare to HPMC K-4M and HPC 75-100 combination. Thedissolution result shows that an increased amount of polymer resulted in reduced drugrelease. A concentration dependent drug release is evident in case of the polymeri.e., lower concentration of polymers, release is marginally retarded at higherconcentration is considerable.Prepared matrix formulation containing HPMC K-4M (F6 ), HPMC K-4M andHPC 75-100 combination (F9 ) probably showing better release based up to 98 % to 99% drug release within 12 hour." @default.
- W2783403645 created "2018-01-26" @default.
- W2783403645 creator A5078127931 @default.
- W2783403645 date "2016-10-01" @default.
- W2783403645 modified "2023-09-27" @default.
- W2783403645 title "Design and Development of Gliclazide Matrix Tablets Using HPC, HPMC and their Combination as a Release Retarding Polymers" @default.
- W2783403645 hasPublicationYear "2016" @default.
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