FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783406743> ?p ?o ?g. }

• W2783406743 endingPage "73" @default.
• W2783406743 startingPage "65" @default.
• W2783406743 abstract "Pretreatment of low-dose lipopolysaccharide (LPS) induces a hyporesponsive state to subsequent secondary challenge with high-dose LPS in innate immune cells, whereas super-low-dose LPS results in augmented expression of pro-inflammatory cytokines. However, little is known about the difference between super-low-dose and low-dose LPS pretreatments on immune cell-mediated inflammatory and hepatic acute-phase responses to secondary LPS. In the present study, RAW 264.7 cells, EL4 cells, and Hepa-1c1c7 cells were pretreated with super-low-dose LPS (SL-LPS: 50 pg/mL) or low-dose LPS (L-LPS: 50 ng/mL) in fresh complete medium once a day for 2~3 days and then cultured in fresh complete medium for 24 hr or 48 hr in the presence or absence of LPS (1~10 μg/mL) or concanavalin A (Con A). SL-LPS pretreatment strongly enhanced the LPS-induced production of tumor necrosis factor (TNF)-α, interleukin (IL)-6, TNF-α/IL-10, prostaglandin E2 (PGE2), and nitric oxide (NO) by RAW 264.7 cells compared to the control, whereas L-LPS increased IL-6 and NO production only. SL-LPS strongly augmented the Con A-induced ratios of interferon (IFN)-γ/IL-10 in EL4 cells but decreased the LPS-induced ratios of IFN-γ/IL-10 compared to the control, while L-LPS decreased the Con A- and LPS-induced ratios of IFN-γ/IL-10. SL-LPS enhanced the LPS-induced production of IL-6 by Hepa1c1c-7 cells compared to the control, while L-LPS increased IL-6 but decreased IL-1β and C reactive protein (CRP) levels. SL-LPS pretreatment strongly enhanced the LPS-induced production of TNF-α, IL-6, IL-10, PGE2, and NO in RAW 264.7 cells, and the IL-6, IL-1β, and CRP levels in Hepa1c1c-7 cells, as well as the ratios of IFN-γ/IL-10 in LPS- and Con A-stimulated EL4 cells compared to L-LPS. These findings suggest that pre-conditioning of SL-LPS may contribute to the mortality to secondary infection in sepsis rather than pre-conditioning of L-LPS." @default.
• W2783406743 created "2018-01-26" @default.
• W2783406743 creator A5062767459 @default.
• W2783406743 date "2018-01-15" @default.
• W2783406743 modified "2023-10-06" @default.
• W2783406743 title "Pretreatment of Low-Dose and Super-Low-Dose LPS on the Production of<i>In Vitro</i>LPS-Induced Inflammatory Mediators" @default.
• W2783406743 cites W1509020639 @default.
• W2783406743 cites W1514327587 @default.
• W2783406743 cites W1579897694 @default.
• W2783406743 cites W1952855042 @default.
• W2783406743 cites W1965168337 @default.
• W2783406743 cites W1970814200 @default.
• W2783406743 cites W1979923792 @default.
• W2783406743 cites W1992075095 @default.
• W2783406743 cites W1993197717 @default.
• W2783406743 cites W2000054651 @default.
• W2783406743 cites W2016648062 @default.
• W2783406743 cites W2018135697 @default.
• W2783406743 cites W2029199833 @default.
• W2783406743 cites W2037349803 @default.
• W2783406743 cites W2044268463 @default.
• W2783406743 cites W2062450447 @default.
• W2783406743 cites W2078833807 @default.
• W2783406743 cites W2080521203 @default.
• W2783406743 cites W2094855663 @default.
• W2783406743 cites W2097782461 @default.
• W2783406743 cites W2105121267 @default.
• W2783406743 cites W2114354400 @default.
• W2783406743 cites W2126698946 @default.
• W2783406743 cites W2128149258 @default.
• W2783406743 cites W2131490293 @default.
• W2783406743 cites W2131536322 @default.
• W2783406743 cites W2139366327 @default.
• W2783406743 cites W2156414024 @default.
• W2783406743 cites W2159728803 @default.
• W2783406743 cites W2246509399 @default.
• W2783406743 cites W2268066121 @default.
• W2783406743 cites W2296531152 @default.
• W2783406743 cites W2360439189 @default.
• W2783406743 cites W2530746425 @default.
• W2783406743 cites W2585566359 @default.
• W2783406743 cites W2642233293 @default.
• W2783406743 cites W2770077799 @default.
• W2783406743 cites W4236273750 @default.
• W2783406743 cites W4313344603 @default.
• W2783406743 cites W769942964 @default.
• W2783406743 doi "https://doi.org/10.5487/tr.2018.34.1.065" @default.
• W2783406743 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5776914" @default.
• W2783406743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29372003" @default.
• W2783406743 hasPublicationYear "2018" @default.
• W2783406743 type Work @default.
• W2783406743 sameAs 2783406743 @default.
• W2783406743 citedByCount "36" @default.
• W2783406743 countsByYear W27834067432018 @default.
• W2783406743 countsByYear W27834067432019 @default.
• W2783406743 countsByYear W27834067432020 @default.
• W2783406743 countsByYear W27834067432021 @default.
• W2783406743 countsByYear W27834067432022 @default.
• W2783406743 countsByYear W27834067432023 @default.
• W2783406743 crossrefType "journal-article" @default.
• W2783406743 hasAuthorship W2783406743A5062767459 @default.
• W2783406743 hasBestOaLocation W27834067431 @default.
• W2783406743 hasConcept C11988809 @default.
• W2783406743 hasConcept C126322002 @default.
• W2783406743 hasConcept C134018914 @default.
• W2783406743 hasConcept C136449434 @default.
• W2783406743 hasConcept C17991360 @default.
• W2783406743 hasConcept C185592680 @default.
• W2783406743 hasConcept C19869320 @default.
• W2783406743 hasConcept C202751555 @default.
• W2783406743 hasConcept C203014093 @default.
• W2783406743 hasConcept C2776914184 @default.
• W2783406743 hasConcept C2777956040 @default.
• W2783406743 hasConcept C2778690821 @default.
• W2783406743 hasConcept C2778754761 @default.
• W2783406743 hasConcept C519581460 @default.
• W2783406743 hasConcept C55493867 @default.
• W2783406743 hasConcept C71924100 @default.
• W2783406743 hasConcept C74172505 @default.
• W2783406743 hasConcept C8891405 @default.
• W2783406743 hasConcept C98274493 @default.
• W2783406743 hasConceptScore W2783406743C11988809 @default.
• W2783406743 hasConceptScore W2783406743C126322002 @default.
• W2783406743 hasConceptScore W2783406743C134018914 @default.
• W2783406743 hasConceptScore W2783406743C136449434 @default.
• W2783406743 hasConceptScore W2783406743C17991360 @default.
• W2783406743 hasConceptScore W2783406743C185592680 @default.
• W2783406743 hasConceptScore W2783406743C19869320 @default.
• W2783406743 hasConceptScore W2783406743C202751555 @default.
• W2783406743 hasConceptScore W2783406743C203014093 @default.
• W2783406743 hasConceptScore W2783406743C2776914184 @default.
• W2783406743 hasConceptScore W2783406743C2777956040 @default.
• W2783406743 hasConceptScore W2783406743C2778690821 @default.
• W2783406743 hasConceptScore W2783406743C2778754761 @default.
• W2783406743 hasConceptScore W2783406743C519581460 @default.
• W2783406743 hasConceptScore W2783406743C55493867 @default.
• W2783406743 hasConceptScore W2783406743C71924100 @default.
• W2783406743 hasConceptScore W2783406743C74172505 @default.

• next