FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783407769> ?p ?o ?g. }

• W2783407769 endingPage "476" @default.
• W2783407769 startingPage "468" @default.
• W2783407769 abstract "Aimed at underlying the molecular regulatory mechanism and overall biological functions of LINC00511 in tongue squamous cell carcinoma (TSCC).The expression level of LINC00511 was examined by QRT-PCR. In particular, Tca-8113 cell line was selected for subsequent experiments, in which the expression level of LINC00511 was the most significant. Meanwhile, the effects of LINC00511 on cells proliferation, cell cycle distribution, and invasion of TSCC cells were explored using RNA knockdown tools with CCK-8, flow cytometry analysis, colony formation, and transwell assay. Further, bioinformatic analysis and the dual-luciferase reporter assay both were conducted to invalidate the ceRNAs regulatory mechanism of LINC00511 in TSCC.LINC00511 was obviously upregulated in TSCC tissues and cell lines. Moreover, it was found that LINC00511 served as a competing endogenous RNA (ceRNA) through sponging miR-765 and ultimately modulated the derepression of laminin subunit gamma 2 (LAMC2). The inhibitory effects of miR-765 on TSCC cells proliferation, invasion as well as cell cycle distribution can be restored by the ectopic overexpression of LINC00511. Additionally, the restored capacity of LINC00511 promoted the expression of LAMC2, which was a downstream target of miR-765 and can be negatively regulated by miR-765.A novel molecular axis of LINC00511/miR-765/LAMC2 was investigated to regulate the tumor development of TSCC. LINC00511 promoted the expression of LAMC2 via the ceRNA mechanism of sponging miR-765. The ceRNA regulatory network provided a novel understanding of TSCC pathogenesis and also shed light on exploiting the new field of lncRNA-directed therapy against TSCC." @default.
• W2783407769 created "2018-01-26" @default.
• W2783407769 creator A5014475350 @default.
• W2783407769 creator A5052947153 @default.
• W2783407769 creator A5059190512 @default.
• W2783407769 date "2018-03-30" @default.
• W2783407769 modified "2023-10-12" @default.
• W2783407769 title "LINC00511 interacts with miR-765 and modulates tongue squamous cell carcinoma progression by targeting LAMC2" @default.
• W2783407769 cites W1964350418 @default.
• W2783407769 cites W1988251250 @default.
• W2783407769 cites W2117331236 @default.
• W2783407769 cites W2502428149 @default.
• W2783407769 cites W2510626203 @default.
• W2783407769 cites W2516968514 @default.
• W2783407769 cites W2517399945 @default.
• W2783407769 cites W2524314645 @default.
• W2783407769 cites W2542593157 @default.
• W2783407769 cites W2551580107 @default.
• W2783407769 cites W2553239296 @default.
• W2783407769 cites W2566306318 @default.
• W2783407769 cites W2606114551 @default.
• W2783407769 cites W2614648335 @default.
• W2783407769 cites W2630396004 @default.
• W2783407769 cites W2730488474 @default.
• W2783407769 cites W2734939827 @default.
• W2783407769 cites W2735456019 @default.
• W2783407769 cites W2735687500 @default.
• W2783407769 cites W2737264786 @default.
• W2783407769 cites W2738271904 @default.
• W2783407769 cites W2901387957 @default.
• W2783407769 doi "https://doi.org/10.1111/jop.12677" @default.
• W2783407769 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29315846" @default.
• W2783407769 hasPublicationYear "2018" @default.
• W2783407769 type Work @default.
• W2783407769 sameAs 2783407769 @default.
• W2783407769 citedByCount "61" @default.
• W2783407769 countsByYear W27834077692018 @default.
• W2783407769 countsByYear W27834077692019 @default.
• W2783407769 countsByYear W27834077692020 @default.
• W2783407769 countsByYear W27834077692021 @default.
• W2783407769 countsByYear W27834077692022 @default.
• W2783407769 countsByYear W27834077692023 @default.
• W2783407769 crossrefType "journal-article" @default.
• W2783407769 hasAuthorship W2783407769A5014475350 @default.
• W2783407769 hasAuthorship W2783407769A5052947153 @default.
• W2783407769 hasAuthorship W2783407769A5059190512 @default.
• W2783407769 hasBestOaLocation W27834077691 @default.
• W2783407769 hasConcept C104317684 @default.
• W2783407769 hasConcept C127561419 @default.
• W2783407769 hasConcept C145059251 @default.
• W2783407769 hasConcept C1491633281 @default.
• W2783407769 hasConcept C153911025 @default.
• W2783407769 hasConcept C173396325 @default.
• W2783407769 hasConcept C29537977 @default.
• W2783407769 hasConcept C502942594 @default.
• W2783407769 hasConcept C54355233 @default.
• W2783407769 hasConcept C553184892 @default.
• W2783407769 hasConcept C55493867 @default.
• W2783407769 hasConcept C60365752 @default.
• W2783407769 hasConcept C62112901 @default.
• W2783407769 hasConcept C62203573 @default.
• W2783407769 hasConcept C81885089 @default.
• W2783407769 hasConcept C86803240 @default.
• W2783407769 hasConcept C95444343 @default.
• W2783407769 hasConcept C97037327 @default.
• W2783407769 hasConceptScore W2783407769C104317684 @default.
• W2783407769 hasConceptScore W2783407769C127561419 @default.
• W2783407769 hasConceptScore W2783407769C145059251 @default.
• W2783407769 hasConceptScore W2783407769C1491633281 @default.
• W2783407769 hasConceptScore W2783407769C153911025 @default.
• W2783407769 hasConceptScore W2783407769C173396325 @default.
• W2783407769 hasConceptScore W2783407769C29537977 @default.
• W2783407769 hasConceptScore W2783407769C502942594 @default.
• W2783407769 hasConceptScore W2783407769C54355233 @default.
• W2783407769 hasConceptScore W2783407769C553184892 @default.
• W2783407769 hasConceptScore W2783407769C55493867 @default.
• W2783407769 hasConceptScore W2783407769C60365752 @default.
• W2783407769 hasConceptScore W2783407769C62112901 @default.
• W2783407769 hasConceptScore W2783407769C62203573 @default.
• W2783407769 hasConceptScore W2783407769C81885089 @default.
• W2783407769 hasConceptScore W2783407769C86803240 @default.
• W2783407769 hasConceptScore W2783407769C95444343 @default.
• W2783407769 hasConceptScore W2783407769C97037327 @default.
• W2783407769 hasIssue "5" @default.
• W2783407769 hasLocation W27834077691 @default.
• W2783407769 hasLocation W27834077692 @default.
• W2783407769 hasOpenAccess W2783407769 @default.
• W2783407769 hasPrimaryLocation W27834077691 @default.
• W2783407769 hasRelatedWork W2354760635 @default.
• W2783407769 hasRelatedWork W2355897695 @default.
• W2783407769 hasRelatedWork W2374592133 @default.
• W2783407769 hasRelatedWork W2387175565 @default.
• W2783407769 hasRelatedWork W2573992804 @default.
• W2783407769 hasRelatedWork W2907903807 @default.
• W2783407769 hasRelatedWork W2943758353 @default.
• W2783407769 hasRelatedWork W3005549771 @default.
• W2783407769 hasRelatedWork W3031841870 @default.
• W2783407769 hasRelatedWork W3130220624 @default.

• next