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- W2783443842 abstract "OBJECTIVE: To prepare SNEDDS of TelmisartanTo convert Liquid SNEDDS to Solid – SNEDDS formTo characterize the prepared SNEDDS for the size, self emulsification time, drugcontent To improve the in vitro dissolution rate of the solid SNEDDS RESULTS AND DISCUSSIONS PREFORMULATION:Melting pointThe melting point was found to be 272˚C which confirms the identification of the drugSolubility studiesSolubility of Telmisartan in different solvents areWater – insolubleEthanol – slightly solubleMethanol – solubleDissolves in 1M sodium hydroxideLAMBDA MAXThe diluted stock which was scanned for maximum wavelength the peak at 296 nm .thiswas selected and was used for further studies SUMMARY AND CONCLUSIONOral route is the most convenient route of administration but it faces the problem of low oralbioavailability. Self nano emulsifying therapeutic system (SNETS) can be used to overcomethe problems faced while using low aqueous soluble drugs. These systems form emulsion insitu with have good stability. This study aimed at investigating the increase in thebioavailability by administering a BCS class II drug, in a SNEDDS form and was comparedto the conventional telmisartan tablets.It can be concluded from the experimental study carried out that the formulation of a poorlywater soluble drug, telmisartan into Self Nanoemulsifying Drug Delivery System yields aformulation with nano size range & good zeta potential. The liquid was further made intotablet form for better stability. The prepared formulations were characterized for the size, zetapotential, self-emulsification time and drug content & compressed into tablets.The in vitro study of the best formulation FT12 SNE tablet showed 1.4 fold increase in thebioavailability when compared to the marketed formulation." @default.
- W2783443842 created "2018-01-26" @default.
- W2783443842 creator A5066825127 @default.
- W2783443842 date "2017-10-01" @default.
- W2783443842 modified "2023-09-26" @default.
- W2783443842 title "Self Nanoemulsifying Tablets of Telmisartan : Development, Characterization, Effect on Dissolution" @default.
- W2783443842 hasPublicationYear "2017" @default.
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