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- W2783446816 abstract "First described by Bruton,1 congenital or X-linked agammaglobulinemia (XLA) is a genetic disorder in the BTK gene that affects the body's ability to produce B cells. Because of the decrease or absence of B cells, patients are at risk for recurrent infection, typically due to bacteria.2 Over the last few decades, the prognosis of XLA has markedly improved because of timely diagnosis and treatment with immunoglobulin replacement therapy.2 Although patients with XLA typically do clinically well with weight-based immunoglobulin dosing, clinicians must factor in concurrent medical conditions that may require dose adjustments." @default.
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- W2783446816 date "2018-05-01" @default.
- W2783446816 modified "2023-10-18" @default.
- W2783446816 title "Identical twins with XLA requiring differing amounts of 20% subcutaneous immunoglobulin secondary to protein-losing enteropathy" @default.
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- W2783446816 doi "https://doi.org/10.1016/j.jaip.2017.11.030" @default.
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