FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783448099> ?p ?o ?g. }

• W2783448099 endingPage "476" @default.
• W2783448099 startingPage "462" @default.
• W2783448099 abstract "SLC26A3 encodes a Cl−/HCO3− ion transporter that is also known as downregulated in adenoma (DRA) and is involved in HCO3−/mucus formation. The role of DRA in the epithelial barrier has not been previously established. In this study, we investigated the in vivo and in vitro mechanisms of DRA in the colon epithelial barrier. Immunofluorescence (IF) and co-immunoprecipitation (co-IP) studies reveal that DRA binds directly to tight junction (TJ) proteins and affects the expression of TJ proteins in polarized Caco-2BBe cells. Similarly, DRA colocalizes with ZO-1 in the intestinal epithelium. Knockdown or overexpression of DRA leads to alterations in TJ proteins and epithelial permeability. In addition, TNF-α treatment downregulates DRA by activating NF-кB and subsequently affecting intestinal epithelial barrier integrity. Furthermore, overexpression of DRA partly reverses the TNF-α-induced damage by stabilizing TJ proteins. Neutralization of TNF-α in dextran sulfate sodium (DSS)-induced colitis mice demonstrates improved the outcomes, and the therapeutic effect of the TNF-α neutralizing mAb is mediated in part by the preservation of DRA expression. These data suggest that DRA may be one of the therapeutic targets of TNF-α. Moreover, DRA delivered by adenovirus vector significantly prevents the exacerbation of colitis and improves epithelial barrier function by promoting the recovery of TJ proteins in DSS-treated mice. In conclusion, DRA plays a role in protecting the epithelial barrier and may be a therapeutic target in gut homeostasis." @default.
• W2783448099 created "2018-01-26" @default.
• W2783448099 creator A5011716316 @default.
• W2783448099 creator A5030197447 @default.
• W2783448099 creator A5035304239 @default.
• W2783448099 creator A5042055301 @default.
• W2783448099 creator A5043972839 @default.
• W2783448099 creator A5049546733 @default.
• W2783448099 creator A5067338796 @default.
• W2783448099 creator A5078504847 @default.
• W2783448099 creator A5084854649 @default.
• W2783448099 date "2018-04-01" @default.
• W2783448099 modified "2023-10-18" @default.
• W2783448099 title "SLC26A3 (DRA) prevents TNF-alpha-induced barrier dysfunction and dextran sulfate sodium-induced acute colitis" @default.
• W2783448099 cites W1486282126 @default.
• W2783448099 cites W1522804491 @default.
• W2783448099 cites W1772212485 @default.
• W2783448099 cites W1844745998 @default.
• W2783448099 cites W1884525829 @default.
• W2783448099 cites W1965987688 @default.
• W2783448099 cites W1972899659 @default.
• W2783448099 cites W1977662414 @default.
• W2783448099 cites W1980018183 @default.
• W2783448099 cites W1992035731 @default.
• W2783448099 cites W1996083842 @default.
• W2783448099 cites W2000191112 @default.
• W2783448099 cites W2004608617 @default.
• W2783448099 cites W2022361664 @default.
• W2783448099 cites W2033417601 @default.
• W2783448099 cites W2035006031 @default.
• W2783448099 cites W2041454039 @default.
• W2783448099 cites W2042932041 @default.
• W2783448099 cites W2043647235 @default.
• W2783448099 cites W2045737849 @default.
• W2783448099 cites W2052036406 @default.
• W2783448099 cites W2076379321 @default.
• W2783448099 cites W2076519131 @default.
• W2783448099 cites W2082119014 @default.
• W2783448099 cites W2088243050 @default.
• W2783448099 cites W2091457240 @default.
• W2783448099 cites W2098086549 @default.
• W2783448099 cites W2121650731 @default.
• W2783448099 cites W2121835630 @default.
• W2783448099 cites W2122756053 @default.
• W2783448099 cites W2131766686 @default.
• W2783448099 cites W2133002738 @default.
• W2783448099 cites W2134923459 @default.
• W2783448099 cites W2145189896 @default.
• W2783448099 cites W2146367607 @default.
• W2783448099 cites W2150933705 @default.
• W2783448099 cites W2159753899 @default.
• W2783448099 cites W2166710590 @default.
• W2783448099 cites W2195770199 @default.
• W2783448099 cites W2330878228 @default.
• W2783448099 cites W2344119092 @default.
• W2783448099 cites W2346180964 @default.
• W2783448099 cites W2399950177 @default.
• W2783448099 cites W2414425800 @default.
• W2783448099 cites W2533293901 @default.
• W2783448099 cites W2604780989 @default.
• W2783448099 cites W2621256940 @default.
• W2783448099 cites W273936932 @default.
• W2783448099 cites W2747732793 @default.
• W2783448099 cites W4289974615 @default.
• W2783448099 doi "https://doi.org/10.1038/s41374-017-0005-4" @default.
• W2783448099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29330471" @default.
• W2783448099 hasPublicationYear "2018" @default.
• W2783448099 type Work @default.
• W2783448099 sameAs 2783448099 @default.
• W2783448099 citedByCount "28" @default.
• W2783448099 countsByYear W27834480992018 @default.
• W2783448099 countsByYear W27834480992019 @default.
• W2783448099 countsByYear W27834480992020 @default.
• W2783448099 countsByYear W27834480992021 @default.
• W2783448099 countsByYear W27834480992022 @default.
• W2783448099 countsByYear W27834480992023 @default.
• W2783448099 crossrefType "journal-article" @default.
• W2783448099 hasAuthorship W2783448099A5011716316 @default.
• W2783448099 hasAuthorship W2783448099A5030197447 @default.
• W2783448099 hasAuthorship W2783448099A5035304239 @default.
• W2783448099 hasAuthorship W2783448099A5042055301 @default.
• W2783448099 hasAuthorship W2783448099A5043972839 @default.
• W2783448099 hasAuthorship W2783448099A5049546733 @default.
• W2783448099 hasAuthorship W2783448099A5067338796 @default.
• W2783448099 hasAuthorship W2783448099A5078504847 @default.
• W2783448099 hasAuthorship W2783448099A5084854649 @default.
• W2783448099 hasBestOaLocation W27834480991 @default.
• W2783448099 hasConcept C126322002 @default.
• W2783448099 hasConcept C153911025 @default.
• W2783448099 hasConcept C159654299 @default.
• W2783448099 hasConcept C173396325 @default.
• W2783448099 hasConcept C177779419 @default.
• W2783448099 hasConcept C17991360 @default.
• W2783448099 hasConcept C185592680 @default.
• W2783448099 hasConcept C190283241 @default.
• W2783448099 hasConcept C203014093 @default.
• W2783448099 hasConcept C2775862500 @default.
• W2783448099 hasConcept C2775962179 @default.

• next