Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783449141> ?p ?o ?g. }
- W2783449141 endingPage "540" @default.
- W2783449141 startingPage "518" @default.
- W2783449141 abstract "The concentrations of reactive oxygen/nitrogen species (ROS/RNS) are critical to various biochemical processes. Small-molecule fluorescent probes have been widely used to detect and/or quantify ROS/RNS in many redox biology studies and serve as an important complementary to protein-based sensors with unique applications. Recent Advances: New sensing reactions have emerged in probe development, allowing more selective and quantitative detection of ROS/RNS, especially in live cells. Improvements have been made in sensing reactions, fluorophores, and bioavailability of probe molecules.In this review, we will not only summarize redox-related small-molecule fluorescent probes but also lay out the challenges of designing probes to help redox biologists independently evaluate the quality of reported small-molecule fluorescent probes, especially in the chemistry literature. We specifically highlight the advantages of reversibility in sensing reactions and its applications in ratiometric probe design for quantitative measurements in living cells. In addition, we compare the advantages and disadvantages of small-molecule probes and protein-based probes.The low physiological relevant concentrations of most ROS/RNS call for new sensing reactions with better selectivity, kinetics, and reversibility; fluorophores with high quantum yield, wide wavelength coverage, and Stokes shifts; and structural design with good aqueous solubility, membrane permeability, low protein interference, and organelle specificity. Antioxid. Redox Signal. 29, 518-540." @default.
- W2783449141 created "2018-01-26" @default.
- W2783449141 creator A5013585925 @default.
- W2783449141 creator A5014782344 @default.
- W2783449141 creator A5018244700 @default.
- W2783449141 creator A5042157267 @default.
- W2783449141 creator A5057083379 @default.
- W2783449141 creator A5069645037 @default.
- W2783449141 date "2018-08-20" @default.
- W2783449141 modified "2023-09-27" @default.
- W2783449141 title "Challenges and Opportunities for Small-Molecule Fluorescent Probes in Redox Biology Applications" @default.
- W2783449141 cites W1756511575 @default.
- W2783449141 cites W1782900133 @default.
- W2783449141 cites W1891740565 @default.
- W2783449141 cites W1958817367 @default.
- W2783449141 cites W1963446535 @default.
- W2783449141 cites W1966956797 @default.
- W2783449141 cites W1968227403 @default.
- W2783449141 cites W1971383450 @default.
- W2783449141 cites W1974446434 @default.
- W2783449141 cites W1974648288 @default.
- W2783449141 cites W1974851160 @default.
- W2783449141 cites W1975053589 @default.
- W2783449141 cites W1976599392 @default.
- W2783449141 cites W1977171217 @default.
- W2783449141 cites W1981897381 @default.
- W2783449141 cites W1981937567 @default.
- W2783449141 cites W1984759027 @default.
- W2783449141 cites W1985846930 @default.
- W2783449141 cites W1988666366 @default.
- W2783449141 cites W1989863077 @default.
- W2783449141 cites W1989980805 @default.
- W2783449141 cites W1989987141 @default.
- W2783449141 cites W1992428974 @default.
- W2783449141 cites W1992890630 @default.
- W2783449141 cites W1993616328 @default.
- W2783449141 cites W1993839684 @default.
- W2783449141 cites W1994043227 @default.
- W2783449141 cites W1994673425 @default.
- W2783449141 cites W1995577457 @default.
- W2783449141 cites W1997161797 @default.
- W2783449141 cites W1997684038 @default.
- W2783449141 cites W1997992505 @default.
- W2783449141 cites W2000205156 @default.
- W2783449141 cites W2002024976 @default.
- W2783449141 cites W2002134534 @default.
- W2783449141 cites W2005184292 @default.
- W2783449141 cites W2006277558 @default.
- W2783449141 cites W2007396482 @default.
- W2783449141 cites W2008071707 @default.
- W2783449141 cites W2009340441 @default.
- W2783449141 cites W2011538447 @default.
- W2783449141 cites W2011921884 @default.
- W2783449141 cites W2012848498 @default.
- W2783449141 cites W2013158621 @default.
- W2783449141 cites W2013970530 @default.
- W2783449141 cites W2014600874 @default.
- W2783449141 cites W2016036293 @default.
- W2783449141 cites W2021969592 @default.
- W2783449141 cites W2022372584 @default.
- W2783449141 cites W2024496732 @default.
- W2783449141 cites W2027861721 @default.
- W2783449141 cites W2028581135 @default.
- W2783449141 cites W2033006728 @default.
- W2783449141 cites W2033939082 @default.
- W2783449141 cites W2035253201 @default.
- W2783449141 cites W2037124284 @default.
- W2783449141 cites W2040382777 @default.
- W2783449141 cites W2041493424 @default.
- W2783449141 cites W2042231461 @default.
- W2783449141 cites W2042624724 @default.
- W2783449141 cites W2042662175 @default.
- W2783449141 cites W2045455905 @default.
- W2783449141 cites W2049061652 @default.
- W2783449141 cites W2049300623 @default.
- W2783449141 cites W2049871526 @default.
- W2783449141 cites W2049990440 @default.
- W2783449141 cites W2051003455 @default.
- W2783449141 cites W2051083365 @default.
- W2783449141 cites W2053240727 @default.
- W2783449141 cites W2053951897 @default.
- W2783449141 cites W2054285810 @default.
- W2783449141 cites W2057141116 @default.
- W2783449141 cites W2058315484 @default.
- W2783449141 cites W2059785923 @default.
- W2783449141 cites W2061734404 @default.
- W2783449141 cites W2061875053 @default.
- W2783449141 cites W2063730048 @default.
- W2783449141 cites W2064004368 @default.
- W2783449141 cites W2064203348 @default.
- W2783449141 cites W2065342373 @default.
- W2783449141 cites W2066194494 @default.
- W2783449141 cites W2066338296 @default.
- W2783449141 cites W2066487508 @default.
- W2783449141 cites W2067646015 @default.
- W2783449141 cites W2071986088 @default.
- W2783449141 cites W2077090609 @default.
- W2783449141 cites W2079355772 @default.