Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783456025> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2783456025 abstract "Background: Impaired coronary flow reserve (CFR) is an early manifestation of coronary artery disease (CAD), even in vessels free of angiographic stenosis. The aim of this analysis is to determine the differential role peak myocardial blood flow (MBF) or noninvasive CFR in predicting future events. Methods: We included 3,003 consecutive patients with known or suspected CAD (mean age 61±11years, 42% females) who underwent rubidium-82 rest/stress positron emission tomography (PET) for clinical indications. Rest and peak MBF were calculated with factor analysis and a 2-compartment kinetic model and were used to calculate CFR. Patients were followed up for a median duration of 1.4 years (interquartile range, 0.5-1.8 years) for the incidence of cardiac death or myocardial infarction. (CDMI). Multiple Cox regression models were used to determine the prognostic value of peak MBF and CFR and the incremental value of peak MBF over CFR. Results: The included cohort has prevalence of CAD risk factors: Diabetes (60%), hypertension (87%) and dyslipidemia (85%). A total of 40% patients had evidence of perfusion defects (Sum stress score>3). After a median follow up duration of 1.4 years, 140 patients (4.7%) experienced CD/MI. In multivariate Cox regression adjusted for Duke clinical risk score, resting ejection fraction and SSS, both CFR (Hazard Ratio 0.70, 95% CI 0.54 -0.89, p=0.005) and peak MBF (Hazard Ratio 0.71, 95% CI 0.57 -0.89, p=0.003) were independent predictors of CDMI. (Adding peak MBF added incremental prognostic value over CFR. (Area under the curve increased from 0.776 to 0.793, p=0.021). Conclusion: Noninvasively measured MBF and CFR are independent predictors of CDMI in patients with known or suspected CAD. Peak MBF adds incremental prognostic value over noninvasive CFR." @default.
- W2783456025 created "2018-01-26" @default.
- W2783456025 creator A5023253601 @default.
- W2783456025 creator A5044731373 @default.
- W2783456025 creator A5054731781 @default.
- W2783456025 creator A5056925068 @default.
- W2783456025 creator A5065510052 @default.
- W2783456025 creator A5068270784 @default.
- W2783456025 date "2015-11-10" @default.
- W2783456025 modified "2023-10-18" @default.
- W2783456025 title "Abstract 14579: Peak Myocardial Blood Flow versus Noninvasive Coronary Flow Reserve for Prediction of Future Events" @default.
- W2783456025 doi "https://doi.org/10.1161/circ.132.suppl_3.14579" @default.
- W2783456025 hasPublicationYear "2015" @default.
- W2783456025 type Work @default.
- W2783456025 sameAs 2783456025 @default.
- W2783456025 citedByCount "1" @default.
- W2783456025 countsByYear W27834560252017 @default.
- W2783456025 crossrefType "journal-article" @default.
- W2783456025 hasAuthorship W2783456025A5023253601 @default.
- W2783456025 hasAuthorship W2783456025A5044731373 @default.
- W2783456025 hasAuthorship W2783456025A5054731781 @default.
- W2783456025 hasAuthorship W2783456025A5056925068 @default.
- W2783456025 hasAuthorship W2783456025A5065510052 @default.
- W2783456025 hasAuthorship W2783456025A5068270784 @default.
- W2783456025 hasConcept C119060515 @default.
- W2783456025 hasConcept C126322002 @default.
- W2783456025 hasConcept C164705383 @default.
- W2783456025 hasConcept C207103383 @default.
- W2783456025 hasConcept C2778198053 @default.
- W2783456025 hasConcept C2778213512 @default.
- W2783456025 hasConcept C2778707443 @default.
- W2783456025 hasConcept C44249647 @default.
- W2783456025 hasConcept C500558357 @default.
- W2783456025 hasConcept C50382708 @default.
- W2783456025 hasConcept C71924100 @default.
- W2783456025 hasConcept C78085059 @default.
- W2783456025 hasConceptScore W2783456025C119060515 @default.
- W2783456025 hasConceptScore W2783456025C126322002 @default.
- W2783456025 hasConceptScore W2783456025C164705383 @default.
- W2783456025 hasConceptScore W2783456025C207103383 @default.
- W2783456025 hasConceptScore W2783456025C2778198053 @default.
- W2783456025 hasConceptScore W2783456025C2778213512 @default.
- W2783456025 hasConceptScore W2783456025C2778707443 @default.
- W2783456025 hasConceptScore W2783456025C44249647 @default.
- W2783456025 hasConceptScore W2783456025C500558357 @default.
- W2783456025 hasConceptScore W2783456025C50382708 @default.
- W2783456025 hasConceptScore W2783456025C71924100 @default.
- W2783456025 hasConceptScore W2783456025C78085059 @default.
- W2783456025 hasIssue "suppl_3" @default.
- W2783456025 hasLocation W27834560251 @default.
- W2783456025 hasOpenAccess W2783456025 @default.
- W2783456025 hasPrimaryLocation W27834560251 @default.
- W2783456025 hasRelatedWork W1788565866 @default.
- W2783456025 hasRelatedWork W1963494405 @default.
- W2783456025 hasRelatedWork W2051296709 @default.
- W2783456025 hasRelatedWork W2110553931 @default.
- W2783456025 hasRelatedWork W2147475043 @default.
- W2783456025 hasRelatedWork W2260294774 @default.
- W2783456025 hasRelatedWork W2424869244 @default.
- W2783456025 hasRelatedWork W2584300006 @default.
- W2783456025 hasRelatedWork W2758867672 @default.
- W2783456025 hasRelatedWork W2791685350 @default.
- W2783456025 hasRelatedWork W2794039944 @default.
- W2783456025 hasRelatedWork W2800990205 @default.
- W2783456025 hasRelatedWork W2884900636 @default.
- W2783456025 hasRelatedWork W2888849768 @default.
- W2783456025 hasRelatedWork W2906060225 @default.
- W2783456025 hasRelatedWork W2970104669 @default.
- W2783456025 hasRelatedWork W3003823983 @default.
- W2783456025 hasRelatedWork W3029880644 @default.
- W2783456025 hasRelatedWork W3127485275 @default.
- W2783456025 hasRelatedWork W3177670945 @default.
- W2783456025 hasVolume "132" @default.
- W2783456025 isParatext "false" @default.
- W2783456025 isRetracted "false" @default.
- W2783456025 magId "2783456025" @default.
- W2783456025 workType "article" @default.