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- W2783456253 abstract "Summary Hematopoiesis is an essential process that evolved in multicellular animals. At the heart of this process are hematopoietic stem cells (HSCs), which are multipotent, self-renewing and generate the entire repertoire of blood and immune cells throughout life. Here we studied the hematopoietic system of Botryllus schlosseri , a colonial tunicate that has vasculature, circulating blood cells, and interesting characteristics of stem cell biology and immunity. Self-recognition between genetically compatible B. schlosseri colonies leads to the formation of natural parabionts with shared circulation, whereas incompatible colonies reject each other. Using flow-cytometry, whole-transcriptome sequencing of defined cell populations, and diverse functional assays, we identified HSCs, progenitors, immune-effector cells, the HSC niche, and demonstrated that self-recognition inhibits cytotoxic reaction. Our study implies that the HSC and myeloid lineages emerged in a common ancestor of tunicates and vertebrates and suggests that hematopoietic bone marrow and the B. schlosseri endostyle niche evolved from the same origin." @default.
- W2783456253 created "2018-01-26" @default.
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- W2783456253 date "2017-12-26" @default.
- W2783456253 modified "2023-09-25" @default.
- W2783456253 title "Evolutionary Origin of the Mammalian Hematopoietic System Found in a Colonial Chordate" @default.
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- W2783456253 doi "https://doi.org/10.1101/206318" @default.
- W2783456253 hasPublicationYear "2017" @default.
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