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- W2783456591 abstract "The popularity of cell therapy as a viable strategy for the research and development of regenerative medicine continues to rise.1 Completed clinical trials have transplanted patient or donor derived cell products as biological packages of potent proregenerative, antifibrotic, and tissue-rejuvenating factors and have fostered the development of new treatments for previously incurable diseases.1,2 However, as a biological agent, cell products are inherently variable because of donor differences, processing techniques, and artificial in vitro laboratory culturing with animal or human products.3 This variability alters the quality and regenerative potency of a cell product and ultimately the clinical outcome. In response, cell-processing protocols must be designed to optimize cell preparation, cell transplantation, and quality assurance for each cell product. Potency assay development and the identification of cell potency biomarkers has become a critical component of current standards for the analysis and enhancement of cell products.Article, see p 255 Mesenchymal stem cells (MSCs) are a leading cell product candidate for the treatment of multiple inflammatory, degenerative, and chronic diseases. Commonly derived from the bone marrow, adipose, and cord tissue, MSCs are easily isolated and can be expanded in large numbers. In addition to direct tissue integration, transplanted MSCs have several paracrine and signaling effects on the tissue. MSCs secrete many beneficial cytokines and cellular compounds (microRNAs and micro vesicles exosomes) that produce immunomodulatory, anti-inflammatory, antifibrotic, promigratory, and proproliferative effects. It is argued that the regenerative potential of MSCs cannot be replaced with a cocktail of …" @default.
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- W2783456591 date "2018-01-19" @default.
- W2783456591 modified "2023-10-11" @default.
- W2783456591 title "Improving Cell Production Techniques to Enhance Autologous Cell Therapy" @default.
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- W2783456591 doi "https://doi.org/10.1161/circresaha.117.312393" @default.
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