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- W2783459036 abstract "Neuropilin-2 (NRP-2) not only functions as a receptor for semaphorins, a family of neural axon guidance factors, but also interacts with VEGFs, a family of vascular endothelial growth factors. As an independent receptor or a co-receptor, NRP-2 binds to ligands VEGF-C/D, activates the VEGF-C/D-NRP-2 signaling axis, and further regulates lymphangiogenesis-associated factors in both lymphatic endothelial cells (LECs) and some tumor cells during tumor progression. Via VEGF-C/D-NRP-2 axis, NRP-2 induces LEC proliferation, reconstruction and lymphangiogenesis and subsequently promotes tumor cell migration, invasion and lymphatic metastasis. There are similarities and differences among NRP-1, NRP-2 and VEGFR-3 in chemical structure, ligand specificity, chromosomal location, soluble protein forms, cellular functions and expression profiles. High expression of NRP-2 in LECs and tumor cells has been observed in different anatomic sites, histological patterns and progression stages of various tumors, especially during tumor lymphangiogenesis and lymphatic metastasis, and therefore the NRP-2 and VEGF-C/D-NRP-2 axis are closely related to tumor development, progression, invasion, and metastasis. In addition, it is important for prognosis of tumor. The studies on NRP-2 targeted therapy have recently achieved some successes, utilizing NRP-2 blocking antibodies, NRP-2 inhibitory peptides, soluble NRP-2 antagonists, small molecule inhibitors and various NRP-2 gene therapeutic strategies." @default.
- W2783459036 created "2018-01-26" @default.
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- W2783459036 date "2018-04-01" @default.
- W2783459036 modified "2023-10-17" @default.
- W2783459036 title "NRP-2 in tumor lymphangiogenesis and lymphatic metastasis" @default.
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- W2783459036 cites W1592915341 @default.
- W2783459036 cites W1821910186 @default.
- W2783459036 cites W1921756464 @default.
- W2783459036 cites W1972381308 @default.
- W2783459036 cites W1972502482 @default.
- W2783459036 cites W1981440485 @default.
- W2783459036 cites W1982025494 @default.
- W2783459036 cites W1983521199 @default.
- W2783459036 cites W1988024355 @default.
- W2783459036 cites W1989443288 @default.
- W2783459036 cites W2000091530 @default.
- W2783459036 cites W2003147884 @default.
- W2783459036 cites W2003742281 @default.
- W2783459036 cites W2004860867 @default.
- W2783459036 cites W2005467912 @default.
- W2783459036 cites W2006433494 @default.
- W2783459036 cites W2013891031 @default.
- W2783459036 cites W2021087194 @default.
- W2783459036 cites W2029698856 @default.
- W2783459036 cites W2032940705 @default.
- W2783459036 cites W2042205488 @default.
- W2783459036 cites W2042349690 @default.
- W2783459036 cites W2042855108 @default.
- W2783459036 cites W2044492345 @default.
- W2783459036 cites W2049553831 @default.
- W2783459036 cites W2060713674 @default.
- W2783459036 cites W2061591294 @default.
- W2783459036 cites W2061744370 @default.
- W2783459036 cites W2073014077 @default.
- W2783459036 cites W2083556560 @default.
- W2783459036 cites W2083629752 @default.
- W2783459036 cites W2089890147 @default.
- W2783459036 cites W2090393106 @default.
- W2783459036 cites W2095103087 @default.
- W2783459036 cites W2097842049 @default.
- W2783459036 cites W2099400970 @default.
- W2783459036 cites W2101017584 @default.
- W2783459036 cites W2101253278 @default.
- W2783459036 cites W2105325479 @default.
- W2783459036 cites W2107305000 @default.
- W2783459036 cites W2108574077 @default.
- W2783459036 cites W2108695923 @default.
- W2783459036 cites W2112633723 @default.
- W2783459036 cites W2113500051 @default.
- W2783459036 cites W2115735927 @default.
- W2783459036 cites W2116384722 @default.
- W2783459036 cites W2116619042 @default.
- W2783459036 cites W2121155612 @default.
- W2783459036 cites W2128470412 @default.
- W2783459036 cites W2134367507 @default.
- W2783459036 cites W2141786561 @default.
- W2783459036 cites W2149163652 @default.
- W2783459036 cites W2152308731 @default.
- W2783459036 cites W2153977729 @default.
- W2783459036 cites W2155244795 @default.
- W2783459036 cites W2157560608 @default.
- W2783459036 cites W2159973050 @default.
- W2783459036 cites W2174613106 @default.
- W2783459036 cites W2290509322 @default.
- W2783459036 cites W2294595461 @default.
- W2783459036 cites W2306738086 @default.
- W2783459036 cites W2309382792 @default.
- W2783459036 cites W2311289295 @default.
- W2783459036 cites W2312553706 @default.
- W2783459036 cites W2323857378 @default.
- W2783459036 cites W2327702252 @default.
- W2783459036 cites W2339824821 @default.
- W2783459036 cites W2509821720 @default.
- W2783459036 cites W2511226617 @default.
- W2783459036 cites W2521891942 @default.
- W2783459036 cites W2572646816 @default.
- W2783459036 cites W2577407126 @default.
- W2783459036 cites W2743305788 @default.
- W2783459036 cites W2753896860 @default.
- W2783459036 doi "https://doi.org/10.1016/j.canlet.2018.01.040" @default.
- W2783459036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29339213" @default.
- W2783459036 hasPublicationYear "2018" @default.
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