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• W2783461983 abstract "The present study describes a study on “Formulation and Evaluation studiesof Acyclovir topical gels for Antiviral activity”Acyclovir is a broad spectrum antiviral agent against Herpes Simplex Virusand Varicella Zoster Virus, which is specific to viral-infected cells with low toxicityand which is less toxic than earlier generation of antiviral agents and as suchrepresents a major therapeutic advance. This drug was selected for the study becauseit has good percutaneous absorption and appears to be more active as antiviralactivity and is well tolerated. The polymers namely Carbopol-934, Carbopol-940,Hydroxypropyl methyl cellulose and Sodium carboxy methyl cellulose were used forformulation of gels and studied for their drug release from the gel formulations.It is evidence from the IR spectrum that all the polymers used in the gelformulations were compatible with the drug Acyclovir.Different formulations of Acyclovir were prepared by using Carbopol-934,Carbopol-940, Hydroxypropyl methyl cellulose and Sodium carboxy methylcellulose in varying proportions. Carbopol gels were transparent, non-greasy andsmooth on application. SodiumCMC and HPMC gels were opaque, non-greasy andsticking on application.The gel was prepared using 1%Carbopol-934 has maximum drug content(101.72%) than the others.The pH of the formulations ranged from 6.8 to 7.2 and viscosity is from36,000 to 51,000cps.Extrudability of carbopol and HPMC gels were excellent than the SodiumCMC gel.The spreadability data shown that the formulation with 1%Carbopol- 934 hasthe highest value (8cm), where as the others have significant values.In vitro release studies of the formulations were carried out across thecellophane membrane using a diffusion cell. The release was highest for theformulation A2 (1%Carbopol-934) and on the addition of DMSO as a permeationenhancer the drug release was improved.The formulation B2, C3 and D2 also have significant percentage release and onaddition of DMSO as a permeation enhancer the drug release from gel formulationwas improved. Hence based on the above results, out of 13 formulations A2 waschosen as the best formulation.Stability studies were carried out by placing the gels in collapsible tube at 4-50c, Room temperature and 37±50C for 3 months and also analyzed for variousphysical and chemical parameters. The result indicates that the prepared gel was bothstable physically and chemically at all storage conditions.From the skin irritation test it was observed that the formulation A2 wasfound to be safer for topical use.In vivo studies were carried out by collecting blood samples from albinorabbits at regular intervals. The plasma drug concentration and pharmacokineticparameters were determined. From the above data it was observed that thebioavailability of the drug in Test was higher than Standard.From this investigation, it was concluded that formulation A2 with 1%Carbopol-934 may be the best formulation having good in vitro release profile,stability and bioavailability. Based on the results from the study further utility of thedosage form may depend on pharmacokinetic data. Forthcoming research work ofantiviral activity may contribute in the challenging area." @default.
• W2783461983 created "2018-01-26" @default.
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• W2783461983 date "2008-03-01" @default.
• W2783461983 modified "2023-09-27" @default.
• W2783461983 title "Formulation and Evaluation Studies of Acyclovir Topical Gels for Antiviral Activity" @default.
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