Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783502086> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W2783502086 abstract "The medial septum has a profound influence on the activity of the hippocampus, through cholinergic and GABAergic innervation. During exploration and paradoxical sleep, the hippocampus produces a prominent voltage oscillation of theta frequency (4-12 Hz), which represents the synchronous activity of hippocampal neurons. This organisation includes the temporal redistribution of inhibition throughout the subcellular domains of pyramidal neurons, via the theta phase locked activity of diverse interneuron populations. GABAergic septo-hippocampal neurons fire rhythmic, phase locked action potentials during theta oscillatory epochs. Within the hippocampus they project exclusively to interneurons; stimulation of the septum disinhibits pyramidal neurons. If the septo-hippocampal projection is inactivated, theta oscillation no longer occurs and animals demonstrate behavioural deficits in episodic memory. This evidence led to the hypothesis that septal rhythmic inhibition of interneurons is a crucial step in the pacing of the hippocampal theta oscillation in vivo. I used extracellular recording and the juxtacellular labelling method of neurons under anaesthesia in vivo to investigate how the electrophysiological activity of septal neurons correlated with the identity of the cell, its axonal arbour and synaptic targets in the hippocampus. I tested the hypothesis that septal neurons display a selective and non-uniform innervation of interneurons and the firing phase and/or spike timing of septal neurons is correlated with that predicted of the innervated hippocampal interneuron(s). I found a diversity of medial septal neurons, which was partially predicted by the firing frequency change during sharp wave associated ripple oscillations. Septal neurons which display significantly different firing patterns and axonal arbours may share molecular markers detected by immunohistochemistry. The axonal arbours of septal neurons were limited to a relatively small area within the hippocampus. Within those regions I defined some of the synaptic targets of three neurons and suggest that septal GABAergic neurons selectively innervate hippocampal interneuron types. Furthermore, the preferred theta phase of septal neurons was out of phase with that predicted for their identified target cells, indicating that septal GABAergic neurons may suppress the firing of interneurons rhythmically during theta." @default.
- W2783502086 created "2018-01-26" @default.
- W2783502086 creator A5074409103 @default.
- W2783502086 date "2016-01-01" @default.
- W2783502086 modified "2023-09-23" @default.
- W2783502086 title "Diverse firing patterns of neurons of the medial septum and their hippocampal targets" @default.
- W2783502086 hasPublicationYear "2016" @default.
- W2783502086 type Work @default.
- W2783502086 sameAs 2783502086 @default.
- W2783502086 citedByCount "0" @default.
- W2783502086 crossrefType "dissertation" @default.
- W2783502086 hasAuthorship W2783502086A5074409103 @default.
- W2783502086 hasConcept C148762608 @default.
- W2783502086 hasConcept C169760540 @default.
- W2783502086 hasConcept C17077164 @default.
- W2783502086 hasConcept C185263204 @default.
- W2783502086 hasConcept C195221683 @default.
- W2783502086 hasConcept C22885893 @default.
- W2783502086 hasConcept C2779177108 @default.
- W2783502086 hasConcept C2779296341 @default.
- W2783502086 hasConcept C2781161787 @default.
- W2783502086 hasConcept C86803240 @default.
- W2783502086 hasConceptScore W2783502086C148762608 @default.
- W2783502086 hasConceptScore W2783502086C169760540 @default.
- W2783502086 hasConceptScore W2783502086C17077164 @default.
- W2783502086 hasConceptScore W2783502086C185263204 @default.
- W2783502086 hasConceptScore W2783502086C195221683 @default.
- W2783502086 hasConceptScore W2783502086C22885893 @default.
- W2783502086 hasConceptScore W2783502086C2779177108 @default.
- W2783502086 hasConceptScore W2783502086C2779296341 @default.
- W2783502086 hasConceptScore W2783502086C2781161787 @default.
- W2783502086 hasConceptScore W2783502086C86803240 @default.
- W2783502086 hasLocation W27835020861 @default.
- W2783502086 hasOpenAccess W2783502086 @default.
- W2783502086 hasPrimaryLocation W27835020861 @default.
- W2783502086 hasRelatedWork W1520323361 @default.
- W2783502086 hasRelatedWork W1571050529 @default.
- W2783502086 hasRelatedWork W1983268123 @default.
- W2783502086 hasRelatedWork W2009439710 @default.
- W2783502086 hasRelatedWork W2017274120 @default.
- W2783502086 hasRelatedWork W2017632516 @default.
- W2783502086 hasRelatedWork W2065291833 @default.
- W2783502086 hasRelatedWork W2074292643 @default.
- W2783502086 hasRelatedWork W2082619124 @default.
- W2783502086 hasRelatedWork W2093513928 @default.
- W2783502086 hasRelatedWork W2141807462 @default.
- W2783502086 hasRelatedWork W2143699555 @default.
- W2783502086 hasRelatedWork W2185941391 @default.
- W2783502086 hasRelatedWork W27254585 @default.
- W2783502086 hasRelatedWork W2890197740 @default.
- W2783502086 hasRelatedWork W2930145255 @default.
- W2783502086 hasRelatedWork W3014139862 @default.
- W2783502086 hasRelatedWork W3049588971 @default.
- W2783502086 hasRelatedWork W3100731418 @default.
- W2783502086 hasRelatedWork W3157851446 @default.
- W2783502086 isParatext "false" @default.
- W2783502086 isRetracted "false" @default.
- W2783502086 magId "2783502086" @default.
- W2783502086 workType "dissertation" @default.