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• W2783503227 endingPage "3822" @default.
• W2783503227 startingPage "3809" @default.
• W2783503227 abstract "There is substantial interest in memory reconsolidation as a target for the treatment of anxiety disorders, such as post-traumatic stress disorder. However, its applicability is restricted by reconsolidation-resistant boundary conditions that constrain the initial memory destabilization. In this study, we investigated whether the induction of synaptic protein degradation through autophagy modulation, a major protein degradation pathway, can enhance memory destabilization upon retrieval and whether it can be used to overcome these conditions. Here, using male mice in an auditory fear reconsolidation model, we showed that autophagy contributes to memory destabilization and its induction can be used to enhance erasure of a reconsolidation-resistant auditory fear memory that depended on AMPAR endocytosis. Using male mice in a contextual fear reconsolidation model, autophagy induction in the amygdala or in the hippocampus enhanced fear or contextual memory destabilization, respectively. The latter correlated with AMPAR degradation in the spines of the contextual memory-ensemble cells. Using male rats in an in vivo LTP reconsolidation model, autophagy induction enhanced synaptic destabilization in an NMDAR-dependent manner. These data indicate that induction of synaptic protein degradation can enhance both synaptic and memory destabilization upon reactivation and that autophagy inducers have the potential to be used as a therapeutic tool in the treatment of anxiety disorders. SIGNIFICANCE STATEMENT It has been reported that inhibiting synaptic protein degradation prevents memory destabilization. However, whether the reverse relation is true and whether it can be used to enhance memory destabilization are still unknown. Here we addressed this question on the behavioral, molecular, and synaptic levels, and showed that induction of autophagy, a major protein degradation pathway, can enhance memory and synaptic destabilization upon reactivation. We also show that autophagy induction can be used to overcome a reconsolidation-resistant memory, suggesting autophagy inducers as a potential therapeutic tool in the treatment of anxiety disorders." @default.
• W2783503227 created "2018-01-26" @default.
• W2783503227 creator A5021270687 @default.
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• W2783503227 creator A5079671620 @default.
• W2783503227 creator A5081480234 @default.
• W2783503227 date "2018-03-19" @default.
• W2783503227 modified "2023-10-17" @default.
• W2783503227 title "Autophagy Enhances Memory Erasure through Synaptic Destabilization" @default.
• W2783503227 cites W1608785134 @default.
• W2783503227 cites W1712523590 @default.
• W2783503227 cites W1900605886 @default.
• W2783503227 cites W1964259998 @default.
• W2783503227 cites W1964908467 @default.
• W2783503227 cites W1966555773 @default.
• W2783503227 cites W1974491267 @default.
• W2783503227 cites W1977077283 @default.
• W2783503227 cites W1977313055 @default.
• W2783503227 cites W1979921881 @default.
• W2783503227 cites W1982864908 @default.
• W2783503227 cites W1984005657 @default.
• W2783503227 cites W1985124617 @default.
• W2783503227 cites W2006001960 @default.
• W2783503227 cites W2009894997 @default.
• W2783503227 cites W2012253485 @default.
• W2783503227 cites W2012639972 @default.
• W2783503227 cites W2012678641 @default.
• W2783503227 cites W2016575029 @default.
• W2783503227 cites W2017056195 @default.
• W2783503227 cites W2018775189 @default.
• W2783503227 cites W2020112095 @default.
• W2783503227 cites W2021141949 @default.
• W2783503227 cites W2022812113 @default.
• W2783503227 cites W2025672359 @default.
• W2783503227 cites W2026268707 @default.
• W2783503227 cites W2026663553 @default.
• W2783503227 cites W2027436298 @default.
• W2783503227 cites W2032700869 @default.
• W2783503227 cites W2032929928 @default.
• W2783503227 cites W2036855091 @default.
• W2783503227 cites W2040653138 @default.
• W2783503227 cites W2041516961 @default.
• W2783503227 cites W2042409347 @default.
• W2783503227 cites W2046496537 @default.
• W2783503227 cites W2048282904 @default.
• W2783503227 cites W2049753507 @default.
• W2783503227 cites W2051902405 @default.
• W2783503227 cites W2056468240 @default.
• W2783503227 cites W2057370954 @default.
• W2783503227 cites W2057596714 @default.
• W2783503227 cites W2059117412 @default.
• W2783503227 cites W2065483210 @default.
• W2783503227 cites W2066358591 @default.
• W2783503227 cites W2071456539 @default.
• W2783503227 cites W2072570863 @default.
• W2783503227 cites W2073243965 @default.
• W2783503227 cites W2079130597 @default.
• W2783503227 cites W2082235945 @default.
• W2783503227 cites W2083217020 @default.
• W2783503227 cites W2087924467 @default.
• W2783503227 cites W2092759474 @default.
• W2783503227 cites W2093116784 @default.
• W2783503227 cites W2098264151 @default.
• W2783503227 cites W2101667399 @default.
• W2783503227 cites W2102418884 @default.
• W2783503227 cites W2108944278 @default.
• W2783503227 cites W2115906580 @default.
• W2783503227 cites W2120012725 @default.
• W2783503227 cites W2124181848 @default.
• W2783503227 cites W2125085972 @default.
• W2783503227 cites W2128537698 @default.
• W2783503227 cites W2128574573 @default.
• W2783503227 cites W2129128619 @default.
• W2783503227 cites W2129971537 @default.
• W2783503227 cites W2140201388 @default.
• W2783503227 cites W2141680511 @default.
• W2783503227 cites W2142650205 @default.
• W2783503227 cites W2143100125 @default.
• W2783503227 cites W2146460558 @default.
• W2783503227 cites W2147065485 @default.
• W2783503227 cites W2147424047 @default.
• W2783503227 cites W2150168624 @default.
• W2783503227 cites W2158553737 @default.
• W2783503227 cites W2161594732 @default.
• W2783503227 cites W2165741741 @default.
• W2783503227 cites W2169578249 @default.
• W2783503227 cites W2171824086 @default.
• W2783503227 cites W2304552143 @default.
• W2783503227 cites W2305524893 @default.
• W2783503227 cites W2344851384 @default.
• W2783503227 cites W2472352469 @default.
• W2783503227 cites W2490444719 @default.
• W2783503227 cites W2558331372 @default.
• W2783503227 cites W2612356851 @default.
• W2783503227 doi "https://doi.org/10.1523/jneurosci.3505-17.2018" @default.
• W2783503227 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6705918" @default.

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