FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783504857> ?p ?o ?g. }

• W2783504857 endingPage "273" @default.
• W2783504857 startingPage "266" @default.
• W2783504857 abstract "To investigate predictive and prognostic value of serum alpha-fetoprotein (AFP) level and its dynamic changes in patients with advanced gastric cancer with elevated serum AFP (AFPAGC).One hundred and five patients with AFPAGC were enrolled in the study, and all of them underwent at least one cycle of systemic chemotherapy at our institute and had serum AFP ≥ 20 ng/mL at diagnosis or recurrence. Clinicopathologic features, serum AFP level at diagnosis and changes during treatment, first-line chemotherapy regimens, efficacy and toxicity, and survival information were collected. A Person's χ2 or Fisher's exact test was used to measure the differences between variables. Survival prognostic factors were investigated using the Kaplan-Meier method and Cox regression.Median serum AFP level was 161.7 ng/mL (range, 22.9-2557110 ng/mL). Objective response rates (ORR) was significantly lower in the AFP ≥ 160 ng/mL group than in the AFP < 160 ng/mL group (30.4% vs 68.3%, P < 0.001). ORR to doublet regimens was significantly lower in the AFP ≥ 160 ng/mL group, whereas ORR to triplet regimens was similar between the two groups. Liver metastasis rate was significantly higher in the AFP ≥ 160 ng/mL group than in the AFP < 160 ng/mL (69.8% vs 50.0%, P < 0.001). Overall survival (OS) in the two cohorts did not show any significant difference (P = 0.712). Dynamic changes of AFP were consistent with response to chemotherapy, and median OS of patients with a serum AFP decline ≥ 50% and those with a serum AFP decline < 50% was 17.5 m and 10.0 m, respectively (P = 0.003). Hepatic (P = 0.005), peritoneal (P < 0.001), non-regional lymph node metastasis (P < 0.001), and portal vein tumor thrombus (PVTT) (P = 0.042) were identified as independent prognostic factors for AFPAGC.Real-time examination of AFP has great predictive and prognostic value for managing AFPAGC. For those with markedly elevated AFP, triplet regimens may be a better choice." @default.
• W2783504857 created "2018-01-26" @default.
• W2783504857 creator A5014406637 @default.
• W2783504857 creator A5046118596 @default.
• W2783504857 creator A5059392900 @default.
• W2783504857 creator A5083365013 @default.
• W2783504857 date "2018-01-14" @default.
• W2783504857 modified "2023-10-01" @default.
• W2783504857 title "Predictive and prognostic value of serum AFP level and its dynamic changes in advanced gastric cancer patients with elevated serum AFP" @default.
• W2783504857 cites W1141772028 @default.
• W2783504857 cites W1964663767 @default.
• W2783504857 cites W1969248336 @default.
• W2783504857 cites W1992467630 @default.
• W2783504857 cites W1999200227 @default.
• W2783504857 cites W2000201423 @default.
• W2783504857 cites W2017539090 @default.
• W2783504857 cites W2017558659 @default.
• W2783504857 cites W2036839010 @default.
• W2783504857 cites W2042839116 @default.
• W2783504857 cites W2047335321 @default.
• W2783504857 cites W2068114976 @default.
• W2783504857 cites W2072571009 @default.
• W2783504857 cites W2095327082 @default.
• W2783504857 cites W2099756738 @default.
• W2783504857 cites W2101313610 @default.
• W2783504857 cites W2104759721 @default.
• W2783504857 cites W2111237964 @default.
• W2783504857 cites W2126547130 @default.
• W2783504857 cites W2155588015 @default.
• W2783504857 cites W2341684562 @default.
• W2783504857 cites W2492575571 @default.
• W2783504857 cites W2519141755 @default.
• W2783504857 cites W2531453937 @default.
• W2783504857 cites W2611570240 @default.
• W2783504857 cites W2729345306 @default.
• W2783504857 cites W2745989101 @default.
• W2783504857 cites W4229845646 @default.
• W2783504857 cites W2136595332 @default.
• W2783504857 doi "https://doi.org/10.3748/wjg.v24.i2.266" @default.
• W2783504857 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5768945" @default.
• W2783504857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29375212" @default.
• W2783504857 hasPublicationYear "2018" @default.
• W2783504857 type Work @default.
• W2783504857 sameAs 2783504857 @default.
• W2783504857 citedByCount "21" @default.
• W2783504857 countsByYear W27835048572019 @default.
• W2783504857 countsByYear W27835048572020 @default.
• W2783504857 countsByYear W27835048572021 @default.
• W2783504857 countsByYear W27835048572022 @default.
• W2783504857 countsByYear W27835048572023 @default.
• W2783504857 crossrefType "journal-article" @default.
• W2783504857 hasAuthorship W2783504857A5014406637 @default.
• W2783504857 hasAuthorship W2783504857A5046118596 @default.
• W2783504857 hasAuthorship W2783504857A5059392900 @default.
• W2783504857 hasAuthorship W2783504857A5083365013 @default.
• W2783504857 hasBestOaLocation W27835048571 @default.
• W2783504857 hasConcept C121608353 @default.
• W2783504857 hasConcept C126322002 @default.
• W2783504857 hasConcept C2776694085 @default.
• W2783504857 hasConcept C2778019345 @default.
• W2783504857 hasConcept C2779013556 @default.
• W2783504857 hasConcept C2780624289 @default.
• W2783504857 hasConcept C50382708 @default.
• W2783504857 hasConcept C71924100 @default.
• W2783504857 hasConcept C90924648 @default.
• W2783504857 hasConceptScore W2783504857C121608353 @default.
• W2783504857 hasConceptScore W2783504857C126322002 @default.
• W2783504857 hasConceptScore W2783504857C2776694085 @default.
• W2783504857 hasConceptScore W2783504857C2778019345 @default.
• W2783504857 hasConceptScore W2783504857C2779013556 @default.
• W2783504857 hasConceptScore W2783504857C2780624289 @default.
• W2783504857 hasConceptScore W2783504857C50382708 @default.
• W2783504857 hasConceptScore W2783504857C71924100 @default.
• W2783504857 hasConceptScore W2783504857C90924648 @default.
• W2783504857 hasIssue "2" @default.
• W2783504857 hasLocation W27835048571 @default.
• W2783504857 hasLocation W27835048572 @default.
• W2783504857 hasLocation W27835048573 @default.
• W2783504857 hasLocation W27835048574 @default.
• W2783504857 hasOpenAccess W2783504857 @default.
• W2783504857 hasPrimaryLocation W27835048571 @default.
• W2783504857 hasRelatedWork W2023543014 @default.
• W2783504857 hasRelatedWork W2055887390 @default.
• W2783504857 hasRelatedWork W2121537719 @default.
• W2783504857 hasRelatedWork W2127396827 @default.
• W2783504857 hasRelatedWork W2128222437 @default.
• W2783504857 hasRelatedWork W2174830166 @default.
• W2783504857 hasRelatedWork W2314032833 @default.
• W2783504857 hasRelatedWork W2361745677 @default.
• W2783504857 hasRelatedWork W2390837439 @default.
• W2783504857 hasRelatedWork W2409070295 @default.
• W2783504857 hasVolume "24" @default.
• W2783504857 isParatext "false" @default.
• W2783504857 isRetracted "false" @default.
• W2783504857 magId "2783504857" @default.
• W2783504857 workType "article" @default.