FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783506888> ?p ?o ?g. }

• W2783506888 abstract "Osteoradionecrosis of the mandible is the most common serious complication of radiotherapy for head and neck malignancy. For decades, hyperbaric oxygen has been employed in efforts to prevent those cases of osteoradionecrosis that are precipitated by dental extractions or implant placement. The evidence for using hyperbaric oxygen remains poor and current clinical practice varies greatly. We describe a protocol for a clinical trial to assess the benefit of hyperbaric oxygen in the prevention of osteoradionecrosis during surgery on the irradiated mandible. The HOPON trial is a phase III, randomised controlled, multi-centre trial. It employs an unblinded trial design, but the assessment of the primary endpoint, i.e. the diagnosis of osteoradionecrosis, is assessed on anonymised clinical photographs and radiographs by a blinded expert panel. Eligibility is through the need for a high-risk dental procedure in the mandible where at least 50-Gy radiotherapy has been received. Patients are randomised 1:1 to hyperbaric oxygen arm (Marx protocol) : control arm, but both groups receive antibiotics and chlorhexidine mouthwash. The primary endpoint is the presence of osteoradionecrosis at 6 months following surgery, but secondary endpoints include other time points, acute symptoms and pain, quality of life, and where implants are placed, their successful retention. The protocol presented has evolved through feasibility stages and through analysis of interim data. The classification of osteoradionecrosis has undergone technical refinement to ensure that robust definitions are employed. The HOPON trial is the only multi-centre RCT conducted in this clinical setting despite decades of use of hyperbaric oxygen for the prevention of osteoradionecrosis. European Clinical Trials Database, ID: EudraCT200700622527 . First registered on 5 November 2007." @default.
• W2783506888 created "2018-01-26" @default.
• W2783506888 creator A5003083563 @default.
• W2783506888 creator A5009341225 @default.
• W2783506888 creator A5020318925 @default.
• W2783506888 creator A5022976380 @default.
• W2783506888 creator A5033000612 @default.
• W2783506888 creator A5036625980 @default.
• W2783506888 creator A5041683332 @default.
• W2783506888 creator A5043140431 @default.
• W2783506888 creator A5043421849 @default.
• W2783506888 creator A5046350949 @default.
• W2783506888 creator A5066256298 @default.
• W2783506888 creator A5085334191 @default.
• W2783506888 creator A5085513358 @default.
• W2783506888 date "2018-01-10" @default.
• W2783506888 modified "2023-10-12" @default.
• W2783506888 title "HOPON (Hyperbaric Oxygen for the Prevention of Osteoradionecrosis): a randomised controlled trial of hyperbaric oxygen to prevent osteoradionecrosis of the irradiated mandible: study protocol for a randomised controlled trial" @default.
• W2783506888 cites W1968846006 @default.
• W2783506888 cites W1982600207 @default.
• W2783506888 cites W1987561637 @default.
• W2783506888 cites W1996396081 @default.
• W2783506888 cites W2016637530 @default.
• W2783506888 cites W2018231734 @default.
• W2783506888 cites W2023080960 @default.
• W2783506888 cites W2030072294 @default.
• W2783506888 cites W2042170975 @default.
• W2783506888 cites W2047446002 @default.
• W2783506888 cites W2073115351 @default.
• W2783506888 cites W2087598804 @default.
• W2783506888 cites W2088190974 @default.
• W2783506888 cites W2098310342 @default.
• W2783506888 cites W2105318860 @default.
• W2783506888 cites W2127788327 @default.
• W2783506888 cites W2132466368 @default.
• W2783506888 cites W2145287322 @default.
• W2783506888 cites W2150837949 @default.
• W2783506888 cites W2153205876 @default.
• W2783506888 cites W2166297968 @default.
• W2783506888 cites W2208973793 @default.
• W2783506888 cites W2324504967 @default.
• W2783506888 cites W2510964327 @default.
• W2783506888 cites W2560453643 @default.
• W2783506888 cites W4231404455 @default.
• W2783506888 doi "https://doi.org/10.1186/s13063-017-2376-7" @default.
• W2783506888 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5761154" @default.
• W2783506888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29316962" @default.
• W2783506888 hasPublicationYear "2018" @default.
• W2783506888 type Work @default.
• W2783506888 sameAs 2783506888 @default.
• W2783506888 citedByCount "10" @default.
• W2783506888 countsByYear W27835068882019 @default.
• W2783506888 countsByYear W27835068882020 @default.
• W2783506888 countsByYear W27835068882021 @default.
• W2783506888 countsByYear W27835068882022 @default.
• W2783506888 countsByYear W27835068882023 @default.
• W2783506888 crossrefType "journal-article" @default.
• W2783506888 hasAuthorship W2783506888A5003083563 @default.
• W2783506888 hasAuthorship W2783506888A5009341225 @default.
• W2783506888 hasAuthorship W2783506888A5020318925 @default.
• W2783506888 hasAuthorship W2783506888A5022976380 @default.
• W2783506888 hasAuthorship W2783506888A5033000612 @default.
• W2783506888 hasAuthorship W2783506888A5036625980 @default.
• W2783506888 hasAuthorship W2783506888A5041683332 @default.
• W2783506888 hasAuthorship W2783506888A5043140431 @default.
• W2783506888 hasAuthorship W2783506888A5043421849 @default.
• W2783506888 hasAuthorship W2783506888A5046350949 @default.
• W2783506888 hasAuthorship W2783506888A5066256298 @default.
• W2783506888 hasAuthorship W2783506888A5085334191 @default.
• W2783506888 hasAuthorship W2783506888A5085513358 @default.
• W2783506888 hasBestOaLocation W27835068881 @default.
• W2783506888 hasConcept C141071460 @default.
• W2783506888 hasConcept C142724271 @default.
• W2783506888 hasConcept C168563851 @default.
• W2783506888 hasConcept C199343813 @default.
• W2783506888 hasConcept C203092338 @default.
• W2783506888 hasConcept C2780037786 @default.
• W2783506888 hasConcept C509974204 @default.
• W2783506888 hasConcept C535046627 @default.
• W2783506888 hasConcept C71924100 @default.
• W2783506888 hasConceptScore W2783506888C141071460 @default.
• W2783506888 hasConceptScore W2783506888C142724271 @default.
• W2783506888 hasConceptScore W2783506888C168563851 @default.
• W2783506888 hasConceptScore W2783506888C199343813 @default.
• W2783506888 hasConceptScore W2783506888C203092338 @default.
• W2783506888 hasConceptScore W2783506888C2780037786 @default.
• W2783506888 hasConceptScore W2783506888C509974204 @default.
• W2783506888 hasConceptScore W2783506888C535046627 @default.
• W2783506888 hasConceptScore W2783506888C71924100 @default.
• W2783506888 hasFunder F4320319985 @default.
• W2783506888 hasIssue "1" @default.
• W2783506888 hasLocation W27835068881 @default.
• W2783506888 hasLocation W27835068882 @default.
• W2783506888 hasLocation W27835068883 @default.
• W2783506888 hasLocation W27835068884 @default.
• W2783506888 hasLocation W27835068885 @default.
• W2783506888 hasOpenAccess W2783506888 @default.
• W2783506888 hasPrimaryLocation W27835068881 @default.
• W2783506888 hasRelatedWork W1974741395 @default.
• W2783506888 hasRelatedWork W1990926855 @default.

• next