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• W2783582599 abstract "Microglia, the CNS-resident immune cells, play important roles in disease, but the spectrum of their possible activation states is not well understood. We derived co-regulated gene modules from transcriptional profiles of CNS myeloid cells of diverse mouse models, including new tauopathy model datasets. Using these modules to interpret single-cell data from an Alzheimer’s disease (AD) model, we identified microglial subsets—distinct from previously reported “disease-associated microglia”—expressing interferon-related or proliferation modules. We then analyzed whole-tissue RNA profiles from human neurodegenerative diseases, including a new AD dataset. Correcting for altered cellular composition of AD tissue, we observed elevated expression of the neurodegeneration-related modules, but also modules not implicated using expression profiles from mouse models alone. We provide a searchable, interactive database for exploring gene expression in all these datasets (http://research-pub.gene.com/BrainMyeloidLandscape). Understanding the dimensions of CNS myeloid cell activation in human disease may reveal opportunities for therapeutic intervention." @default.
• W2783582599 created "2018-01-26" @default.
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• W2783582599 date "2018-01-01" @default.
• W2783582599 modified "2023-10-17" @default.
• W2783582599 title "Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models" @default.
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• W2783582599 doi "https://doi.org/10.1016/j.celrep.2017.12.066" @default.
• W2783582599 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29346778" @default.
• W2783582599 hasPublicationYear "2018" @default.
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