FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783603721> ?p ?o ?g. }

• W2783603721 endingPage "118" @default.
• W2783603721 startingPage "107" @default.
• W2783603721 abstract "Fingolimod (FTY720), an immunomodulator, is approved as an oral treatment for patients with relapsing forms of multiple sclerosis. Its effects are largely attributed to its mechanism of selectively retaining lymphocytes in the lymph nodes to reduce autoreactive T-cell recruitment in the CNS. In this study, we investigated the therapeutic effect of FTY720 on an animal model of CNS inflammation induced by intracerebral ventricle LPS injection. We found that FTY720 treatment significantly prevented LPS-induced neutrophil recruitment in the CNS by inhibiting leukocyte recruitment in cerebral microvessels. Furthermore, FTY720 also inhibited the expressions of adhesion molecules on the cerebral endothelium, but did not affect the expression levels of pro-inflammatory cytokines (TNF-α and IL-6) and chemokines (CXCL1 and CXCL2) in the CNS parenchyma. The inhibition of endothelial activation was accompanied by reduced phosphorylation of signaling molecules, including serine/threonine-specific protein kinase (Akt), STAT6, and nuclear factor-κB. This FTY720-attenuated inhibition of leukocyte recruitment and endothelial activation was reversed by blocking the functions of sphingosine kinase 2 or sphingosine-1-phosphate receptor 1. Our study demonstrated, for the first time, that FTY720 directly inhibits the phosphorylation of multiple signaling molecules in endothelial cells, thereby effectively blocking leukocyte recruitment in the CNS." @default.
• W2783603721 created "2018-01-26" @default.
• W2783603721 creator A5008118059 @default.
• W2783603721 creator A5013739843 @default.
• W2783603721 creator A5026352582 @default.
• W2783603721 creator A5027637747 @default.
• W2783603721 creator A5051229707 @default.
• W2783603721 creator A5057302929 @default.
• W2783603721 creator A5057513521 @default.
• W2783603721 creator A5063636244 @default.
• W2783603721 creator A5065705224 @default.
• W2783603721 creator A5082508377 @default.
• W2783603721 date "2017-12-06" @default.
• W2783603721 modified "2023-10-15" @default.
• W2783603721 title "Fingolimod targets cerebral endothelial activation to block leukocyte recruitment in the central nervous system" @default.
• W2783603721 cites W1607342455 @default.
• W2783603721 cites W1790645982 @default.
• W2783603721 cites W1892809027 @default.
• W2783603721 cites W1933215500 @default.
• W2783603721 cites W1967802627 @default.
• W2783603721 cites W1968631247 @default.
• W2783603721 cites W1969841262 @default.
• W2783603721 cites W1987289843 @default.
• W2783603721 cites W1997327044 @default.
• W2783603721 cites W1999975964 @default.
• W2783603721 cites W2006073149 @default.
• W2783603721 cites W2017151158 @default.
• W2783603721 cites W2019209482 @default.
• W2783603721 cites W2024215619 @default.
• W2783603721 cites W2024898420 @default.
• W2783603721 cites W2028031986 @default.
• W2783603721 cites W2035208392 @default.
• W2783603721 cites W2036199376 @default.
• W2783603721 cites W2047231993 @default.
• W2783603721 cites W2051485704 @default.
• W2783603721 cites W2069634387 @default.
• W2783603721 cites W2077783001 @default.
• W2783603721 cites W2078775078 @default.
• W2783603721 cites W2083974928 @default.
• W2783603721 cites W2093086643 @default.
• W2783603721 cites W2108352126 @default.
• W2783603721 cites W2108813293 @default.
• W2783603721 cites W2109380000 @default.
• W2783603721 cites W2118735809 @default.
• W2783603721 cites W2127740643 @default.
• W2783603721 cites W2128021781 @default.
• W2783603721 cites W2130277789 @default.
• W2783603721 cites W2138694950 @default.
• W2783603721 cites W2139319526 @default.
• W2783603721 cites W2142912421 @default.
• W2783603721 cites W2144011204 @default.
• W2783603721 cites W2145360779 @default.
• W2783603721 cites W2149707050 @default.
• W2783603721 cites W2154089780 @default.
• W2783603721 cites W2167876561 @default.
• W2783603721 cites W2170098900 @default.
• W2783603721 cites W2171316388 @default.
• W2783603721 cites W2175457159 @default.
• W2783603721 cites W2274886384 @default.
• W2783603721 doi "https://doi.org/10.1002/jlb.3a0717-287r" @default.
• W2783603721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29345065" @default.
• W2783603721 hasPublicationYear "2017" @default.
• W2783603721 type Work @default.
• W2783603721 sameAs 2783603721 @default.
• W2783603721 citedByCount "15" @default.
• W2783603721 countsByYear W27836037212018 @default.
• W2783603721 countsByYear W27836037212019 @default.
• W2783603721 countsByYear W27836037212020 @default.
• W2783603721 countsByYear W27836037212021 @default.
• W2783603721 countsByYear W27836037212022 @default.
• W2783603721 countsByYear W27836037212023 @default.
• W2783603721 crossrefType "journal-article" @default.
• W2783603721 hasAuthorship W2783603721A5008118059 @default.
• W2783603721 hasAuthorship W2783603721A5013739843 @default.
• W2783603721 hasAuthorship W2783603721A5026352582 @default.
• W2783603721 hasAuthorship W2783603721A5027637747 @default.
• W2783603721 hasAuthorship W2783603721A5051229707 @default.
• W2783603721 hasAuthorship W2783603721A5057302929 @default.
• W2783603721 hasAuthorship W2783603721A5057513521 @default.
• W2783603721 hasAuthorship W2783603721A5063636244 @default.
• W2783603721 hasAuthorship W2783603721A5065705224 @default.
• W2783603721 hasAuthorship W2783603721A5082508377 @default.
• W2783603721 hasBestOaLocation W27836037211 @default.
• W2783603721 hasConcept C11960822 @default.
• W2783603721 hasConcept C13373296 @default.
• W2783603721 hasConcept C140800825 @default.
• W2783603721 hasConcept C146285616 @default.
• W2783603721 hasConcept C16224149 @default.
• W2783603721 hasConcept C167734588 @default.
• W2783603721 hasConcept C170493617 @default.
• W2783603721 hasConcept C203014093 @default.
• W2783603721 hasConcept C2776036978 @default.
• W2783603721 hasConcept C2776914184 @default.
• W2783603721 hasConcept C2777025900 @default.
• W2783603721 hasConcept C2778703144 @default.
• W2783603721 hasConcept C2780640218 @default.
• W2783603721 hasConcept C502942594 @default.
• W2783603721 hasConcept C55493867 @default.

• next