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• W2783604085 abstract "Gli3 is a Hedgehog (Hh)-responsive transcription factor that can function as a transcriptional repressor or activator. We show that Gli3 activity in mouse thymic epithelial cells (TECs) promotes positive selection and differentiation from CD4+ CD8+ to CD4+ CD8- single-positive (SP4) cells in the fetal thymus and that Gli3 represses Shh Constitutive deletion of Gli3, and conditional deletion of Gli3 from TECs, reduced differentiation to SP4, whereas conditional deletion of Gli3 from thymocytes did not. Conditional deletion of Shh from TECs increased differentiation to SP4, and expression of Shh was upregulated in the Gli3-deficient thymus. Use of a transgenic Hh reporter showed that the Hh pathway was active in thymocytes, and increased in the Gli3-deficient fetal thymus. Neutralisation of endogenous Hh proteins in the Gli3-/- thymus restored SP4 differentiation, indicating that Gli3 in TECs promotes SP4 differentiation by repression of Shh Transcriptome analysis showed that Hh-mediated transcription was increased whereas TCR-mediated transcription was decreased in Gli3-/- thymocytes compared with wild type." @default.
• W2783604085 created "2018-01-26" @default.
• W2783604085 creator A5012571204 @default.
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• W2783604085 creator A5083841665 @default.
• W2783604085 date "2018-01-01" @default.
• W2783604085 modified "2023-10-06" @default.
• W2783604085 title "In the fetal thymus, Gli3 in thymic epithelial cells promotes thymocyte positive selection and differentiation by repression of<i>Shh</i>" @default.
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• W2783604085 cites W1512693074 @default.
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• W2783604085 cites W1567420244 @default.
• W2783604085 cites W1912218378 @default.
• W2783604085 cites W1976171257 @default.
• W2783604085 cites W1979517153 @default.
• W2783604085 cites W1985923352 @default.
• W2783604085 cites W1986805971 @default.
• W2783604085 cites W1987679046 @default.
• W2783604085 cites W1989718881 @default.
• W2783604085 cites W1994836446 @default.
• W2783604085 cites W2000617957 @default.
• W2783604085 cites W2001620057 @default.
• W2783604085 cites W2002817805 @default.
• W2783604085 cites W2003096689 @default.
• W2783604085 cites W2003730490 @default.
• W2783604085 cites W2005273809 @default.
• W2783604085 cites W2005423745 @default.
• W2783604085 cites W2006194664 @default.
• W2783604085 cites W2010072150 @default.
• W2783604085 cites W2012335408 @default.
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• W2783604085 cites W2026828026 @default.
• W2783604085 cites W2029324939 @default.
• W2783604085 cites W2029943434 @default.
• W2783604085 cites W2030078792 @default.
• W2783604085 cites W2032406291 @default.
• W2783604085 cites W2034400748 @default.
• W2783604085 cites W2035253030 @default.
• W2783604085 cites W2045214716 @default.
• W2783604085 cites W2048257515 @default.
• W2783604085 cites W2054657634 @default.
• W2783604085 cites W2066479550 @default.
• W2783604085 cites W2069534355 @default.
• W2783604085 cites W2069970595 @default.
• W2783604085 cites W2072013743 @default.
• W2783604085 cites W2075876263 @default.
• W2783604085 cites W2076176535 @default.
• W2783604085 cites W2086050331 @default.
• W2783604085 cites W2091869267 @default.
• W2783604085 cites W2095575759 @default.
• W2783604085 cites W2097861892 @default.
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• W2783604085 cites W2103998919 @default.
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• W2783604085 cites W2131582512 @default.
• W2783604085 cites W2134386050 @default.
• W2783604085 cites W2138675753 @default.
• W2783604085 cites W2140273359 @default.
• W2783604085 cites W2144639141 @default.
• W2783604085 cites W2150792914 @default.
• W2783604085 cites W2157103346 @default.
• W2783604085 cites W2161663577 @default.
• W2783604085 cites W2163599242 @default.
• W2783604085 cites W2163838718 @default.
• W2783604085 cites W2166741473 @default.
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• W2783604085 doi "https://doi.org/10.1242/dev.146910" @default.
• W2783604085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5817998" @default.
• W2783604085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29361554" @default.
• W2783604085 hasPublicationYear "2018" @default.
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