FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783607048> ?p ?o ?g. }

• W2783607048 endingPage "1044" @default.
• W2783607048 startingPage "1033" @default.
• W2783607048 abstract "The Hsp90 family of molecular chaperones oversees the folding of a wide range of client proteins. Hsp90 is a homodimer, whose conformational states and functions are regulated by ATP-binding and hydrolysis. The crystal structure of mitochondrial Hsp90 (Trap1) showed that one of the two protomers in the active state is buckled, resulting in an asymmetric conformation. The asymmetry between the two protomers corresponds to the broadly conserved region responsible for client binding. Moreover, asymmetry determines differential hydrolysis for each protomer, with the buckled conformation favoring ATP processing. Experimental results show that after the first hydrolysis the dimer flips to a different asymmetric state while remaining in a closed conformation for the second hydrolysis. In this model, asymmetry plays a key role in the mechanism that drives chaperone function. Herein, we investigate the nucleotide-dependent internal dynamics of Trap1 with computational approaches. Our results shed light on the relationship between the nucleotide state in the N-terminal domain and the asymmetric modulation of the dynamic and structural properties of the client-binding region in the Middle domain. According to our analysis, this is the region that undergoes the most intense dynamic modulation upon nucleotide exchange. This result provides molecular insights into the roles of structural asymmetry in the regulation of Trap1 and suggests that this substructure is a promising target to modulate the functionally oriented aspects of Trap1 dynamics, therefore opening fresh opportunities for the design of selective therapeutics for Trap1-dependent diseases." @default.
• W2783607048 created "2018-01-26" @default.
• W2783607048 creator A5046491394 @default.
• W2783607048 creator A5069152410 @default.
• W2783607048 creator A5081416783 @default.
• W2783607048 date "2018-01-26" @default.
• W2783607048 modified "2023-10-17" @default.
• W2783607048 title "The Structural Asymmetry of Mitochondrial Hsp90 (Trap1) Determines Fine Tuning of Functional Dynamics" @default.
• W2783607048 cites W1555861316 @default.
• W2783607048 cites W1966078827 @default.
• W2783607048 cites W1966238197 @default.
• W2783607048 cites W1970081412 @default.
• W2783607048 cites W1971108880 @default.
• W2783607048 cites W1976499671 @default.
• W2783607048 cites W1996404514 @default.
• W2783607048 cites W2004349079 @default.
• W2783607048 cites W2013226867 @default.
• W2783607048 cites W2014252415 @default.
• W2783607048 cites W2015117663 @default.
• W2783607048 cites W2021049179 @default.
• W2783607048 cites W2021440731 @default.
• W2783607048 cites W2029103952 @default.
• W2783607048 cites W2033906450 @default.
• W2783607048 cites W2035266068 @default.
• W2783607048 cites W2038441129 @default.
• W2783607048 cites W2039975390 @default.
• W2783607048 cites W2041205020 @default.
• W2783607048 cites W2047682506 @default.
• W2783607048 cites W2049475242 @default.
• W2783607048 cites W2055560422 @default.
• W2783607048 cites W2067174909 @default.
• W2783607048 cites W2076318919 @default.
• W2783607048 cites W2078371133 @default.
• W2783607048 cites W2085898992 @default.
• W2783607048 cites W2088624472 @default.
• W2783607048 cites W2090940245 @default.
• W2783607048 cites W2090987603 @default.
• W2783607048 cites W2097164795 @default.
• W2783607048 cites W2103945336 @default.
• W2783607048 cites W2106140689 @default.
• W2783607048 cites W2109982971 @default.
• W2783607048 cites W2127103008 @default.
• W2783607048 cites W2128572087 @default.
• W2783607048 cites W2138821198 @default.
• W2783607048 cites W2143006255 @default.
• W2783607048 cites W2147891181 @default.
• W2783607048 cites W2149744037 @default.
• W2783607048 cites W2154319440 @default.
• W2783607048 cites W2159138687 @default.
• W2783607048 cites W2161534992 @default.
• W2783607048 cites W2316638703 @default.
• W2783607048 cites W2326010744 @default.
• W2783607048 cites W2329720911 @default.
• W2783607048 cites W2521056581 @default.
• W2783607048 cites W2587928091 @default.
• W2783607048 cites W2598147689 @default.
• W2783607048 cites W2885134480 @default.
• W2783607048 cites W4210407906 @default.
• W2783607048 doi "https://doi.org/10.1021/acs.jctc.7b00766" @default.
• W2783607048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29320629" @default.
• W2783607048 hasPublicationYear "2018" @default.
• W2783607048 type Work @default.
• W2783607048 sameAs 2783607048 @default.
• W2783607048 citedByCount "47" @default.
• W2783607048 countsByYear W27836070482018 @default.
• W2783607048 countsByYear W27836070482019 @default.
• W2783607048 countsByYear W27836070482020 @default.
• W2783607048 countsByYear W27836070482021 @default.
• W2783607048 countsByYear W27836070482022 @default.
• W2783607048 countsByYear W27836070482023 @default.
• W2783607048 crossrefType "journal-article" @default.
• W2783607048 hasAuthorship W2783607048A5046491394 @default.
• W2783607048 hasAuthorship W2783607048A5069152410 @default.
• W2783607048 hasAuthorship W2783607048A5081416783 @default.
• W2783607048 hasConcept C104317684 @default.
• W2783607048 hasConcept C113027372 @default.
• W2783607048 hasConcept C121332964 @default.
• W2783607048 hasConcept C12554922 @default.
• W2783607048 hasConcept C141315368 @default.
• W2783607048 hasConcept C147597530 @default.
• W2783607048 hasConcept C178790620 @default.
• W2783607048 hasConcept C181199279 @default.
• W2783607048 hasConcept C185592680 @default.
• W2783607048 hasConcept C205260736 @default.
• W2783607048 hasConcept C23265538 @default.
• W2783607048 hasConcept C2775932338 @default.
• W2783607048 hasConcept C2779546866 @default.
• W2783607048 hasConcept C38976095 @default.
• W2783607048 hasConcept C512185932 @default.
• W2783607048 hasConcept C55493867 @default.
• W2783607048 hasConcept C59593255 @default.
• W2783607048 hasConcept C62520636 @default.
• W2783607048 hasConcept C71240020 @default.
• W2783607048 hasConcept C86803240 @default.
• W2783607048 hasConceptScore W2783607048C104317684 @default.
• W2783607048 hasConceptScore W2783607048C113027372 @default.
• W2783607048 hasConceptScore W2783607048C121332964 @default.
• W2783607048 hasConceptScore W2783607048C12554922 @default.

• next