FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783608116> ?p ?o ?g. }

• W2783608116 abstract "Background: Idarubicin is an anthracycline antibiotic drug widely used in chemotherapy. Dexrazoxane is an iron chelator used clinically against anthracyclines-induced cardiotoxicity. The present study was designed to determine the possible genoprotection of dexrazoxane on idarubicin-induced DNA damage and oxidative stress. Methods: In this study, the induction of DNA damage by idarubicin was examined on HepG2 cells, using comet assay. Cells were exposed to different concentrations of idarubicin in order to find the minimum and suitable genotoxic concentration. To survey the genoprotective effects of dexrazoxane, cells were subjected to several safe concentrations of dexrazoxane (10, 50, 100, and 200 µM) for 24 hours followed by 1 hour exposure to established genotoxic concentration of idarubicin (0.05 µM). Lipid peroxidation was assessed as a biomarker to show the index of oxidative stress and a possible mechanism underlying this amelioration. Results: Dexrazoxane pre-treatment significantly reduced different parameters of DNA migration such as tail length, % DNA in tail, and tail moment. Moreover, the treatment of dexrazoxane (200 µM) decreased the severity of idarubicin-induced lipid peroxidation. Conclusions: Dexrazoxane in addition to cardioprotection against idarubicin-induced cardiotoxicity has the potential to attenuate its DNA damage and lipid peroxidation in normal cells of patients with cancer treated with idarubicin." @default.
• W2783608116 created "2018-01-26" @default.
• W2783608116 creator A5003689717 @default.
• W2783608116 creator A5040480325 @default.
• W2783608116 creator A5040975584 @default.
• W2783608116 date "2018-01-14" @default.
• W2783608116 modified "2023-09-26" @default.
• W2783608116 title "Modulatory Effects of Dexrazoxane Against Genotoxicity and Lipid Peroxidation Induced by Idarubicin in HepG2 Cells" @default.
• W2783608116 cites W145720774 @default.
• W2783608116 cites W1509435897 @default.
• W2783608116 cites W1571521625 @default.
• W2783608116 cites W1853436903 @default.
• W2783608116 cites W1861929829 @default.
• W2783608116 cites W1904077873 @default.
• W2783608116 cites W1971882647 @default.
• W2783608116 cites W1976177449 @default.
• W2783608116 cites W1977500658 @default.
• W2783608116 cites W1983310681 @default.
• W2783608116 cites W1989781109 @default.
• W2783608116 cites W1992437129 @default.
• W2783608116 cites W2010183849 @default.
• W2783608116 cites W2011552778 @default.
• W2783608116 cites W2031423487 @default.
• W2783608116 cites W2031971494 @default.
• W2783608116 cites W2037515038 @default.
• W2783608116 cites W2039658296 @default.
• W2783608116 cites W2044142379 @default.
• W2783608116 cites W2051580798 @default.
• W2783608116 cites W2052507255 @default.
• W2783608116 cites W2060782429 @default.
• W2783608116 cites W2066214189 @default.
• W2783608116 cites W2071407201 @default.
• W2783608116 cites W2075870956 @default.
• W2783608116 cites W2078780075 @default.
• W2783608116 cites W2092629964 @default.
• W2783608116 cites W2106926141 @default.
• W2783608116 cites W2113009242 @default.
• W2783608116 cites W2124101383 @default.
• W2783608116 cites W2126902508 @default.
• W2783608116 cites W2128208300 @default.
• W2783608116 cites W2128587010 @default.
• W2783608116 cites W2161795005 @default.
• W2783608116 cites W2290994411 @default.
• W2783608116 cites W2339159581 @default.
• W2783608116 cites W2465434953 @default.
• W2783608116 cites W37325350 @default.
• W2783608116 doi "https://doi.org/10.5812/ijcm.9675" @default.
• W2783608116 hasPublicationYear "2018" @default.
• W2783608116 type Work @default.
• W2783608116 sameAs 2783608116 @default.
• W2783608116 citedByCount "0" @default.
• W2783608116 crossrefType "journal-article" @default.
• W2783608116 hasAuthorship W2783608116A5003689717 @default.
• W2783608116 hasAuthorship W2783608116A5040480325 @default.
• W2783608116 hasAuthorship W2783608116A5040975584 @default.
• W2783608116 hasBestOaLocation W27836081161 @default.
• W2783608116 hasConcept C121608353 @default.
• W2783608116 hasConcept C126322002 @default.
• W2783608116 hasConcept C143425029 @default.
• W2783608116 hasConcept C185592680 @default.
• W2783608116 hasConcept C2776151105 @default.
• W2783608116 hasConcept C2776694085 @default.
• W2783608116 hasConcept C2776802502 @default.
• W2783608116 hasConcept C2778041864 @default.
• W2783608116 hasConcept C2778233292 @default.
• W2783608116 hasConcept C2778959862 @default.
• W2783608116 hasConcept C2779117419 @default.
• W2783608116 hasConcept C2779720357 @default.
• W2783608116 hasConcept C2780358455 @default.
• W2783608116 hasConcept C2780829032 @default.
• W2783608116 hasConcept C2781021840 @default.
• W2783608116 hasConcept C29730261 @default.
• W2783608116 hasConcept C530470458 @default.
• W2783608116 hasConcept C552990157 @default.
• W2783608116 hasConcept C55493867 @default.
• W2783608116 hasConcept C71924100 @default.
• W2783608116 hasConcept C98274493 @default.
• W2783608116 hasConceptScore W2783608116C121608353 @default.
• W2783608116 hasConceptScore W2783608116C126322002 @default.
• W2783608116 hasConceptScore W2783608116C143425029 @default.
• W2783608116 hasConceptScore W2783608116C185592680 @default.
• W2783608116 hasConceptScore W2783608116C2776151105 @default.
• W2783608116 hasConceptScore W2783608116C2776694085 @default.
• W2783608116 hasConceptScore W2783608116C2776802502 @default.
• W2783608116 hasConceptScore W2783608116C2778041864 @default.
• W2783608116 hasConceptScore W2783608116C2778233292 @default.
• W2783608116 hasConceptScore W2783608116C2778959862 @default.
• W2783608116 hasConceptScore W2783608116C2779117419 @default.
• W2783608116 hasConceptScore W2783608116C2779720357 @default.
• W2783608116 hasConceptScore W2783608116C2780358455 @default.
• W2783608116 hasConceptScore W2783608116C2780829032 @default.
• W2783608116 hasConceptScore W2783608116C2781021840 @default.
• W2783608116 hasConceptScore W2783608116C29730261 @default.
• W2783608116 hasConceptScore W2783608116C530470458 @default.
• W2783608116 hasConceptScore W2783608116C552990157 @default.
• W2783608116 hasConceptScore W2783608116C55493867 @default.
• W2783608116 hasConceptScore W2783608116C71924100 @default.
• W2783608116 hasConceptScore W2783608116C98274493 @default.
• W2783608116 hasIssue "1" @default.
• W2783608116 hasLocation W27836081161 @default.

• next