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• W2783609090 abstract "Abstract Molecular imaging of vesicular acetylcholine transporter ( VACh T) in the brain provides an important cholinergic biomarker for the pathophysiology and treatment of dementias including Alzheimer's disease. In this study, kinetics modeling methods were applied and compared for quantifying regional brain uptake of the VACh T‐specific positron emission tomography radiotracer, ((−)‐(1‐(‐8‐(2‐fluoroethoxy)‐3‐hydroxy‐1,2,3,4‐tetrahydronaphthalen‐2‐yl)piperidin‐4‐yl)(4‐fluorophenyl)‐methanone) ([ 18 F]V AT ) in macaques. Total volume distribution ( V T ) estimates were compared for one‐tissue compartment model (1 TCM ), two‐tissue compartment model (2 TCM ), Logan graphic analysis (LoganA IF ) and multiple linear analysis (M A 1) with arterial blood input function using data from three macaques. Using the cerebellum‐hemispheres as the reference region with data from seven macaques, three additional models were compared: reference tissue model ( RTM ), simplified RTM ( SRTM ), and Logan graphic analysis (Logan REF ). Model selection criterion indicated that a) 2 TCM and SRTM were the most appropriate kinetics models for [ 18 F]V AT ; and b) S RTM was strongly correlated with 2 TCM (Pearson's coefficients r > 0.93, p < 0.05). Test–retest studies demonstrated that [ 18 F]V AT has good reproducibility and reliability ( TRV < 10%, ICC > 0.72). These studies demonstrate [ 18 F]V AT is a promising VACh T positron emission tomography tracer for quantitative assessment of VACh T levels in the brain of living subjects. image" @default.
• W2783609090 created "2018-01-26" @default.
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• W2783609090 date "2018-03-01" @default.
• W2783609090 modified "2023-10-14" @default.
• W2783609090 title "Kinetic modeling of [¹⁸F]V<scp>AT</scp>, a novel radioligand for positron emission tomography imaging vesicular acetylcholine transporter in non‐human primate brain" @default.
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• W2783609090 doi "https://doi.org/10.1111/jnc.14291" @default.
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