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- W2783609156 abstract "Cells from elderly individuals can by scientists be reprogrammed back to totipotent or pluripotent cells. The first method that achieved reprogramming to totipotency (and thereby pluripotency) was cloning of animals, for example, creation of cloned frogs or Dolly. We and others identified that the protein Oct4 encoded by Pou5f1 gene was a key player in that reprogramming process. Further, epigenetic modifications in the control region of Pou5f1 needed to be reset for the cloning procedure to succeed. The iPS (induced pluripotent stem) cell technology generates pluripotent cells. These cells are promising candidates for regenerative medicine, because of their capability to multiply and differentiate into any cell of interest. Today, a clinical trial is ongoing using cells derived from iPS cells for macular degenerative disease. The iPS cells are also useful for studying human diseases in a dish and drug-screening purposes. The purpose of this article is to introduce the iPS technology and to present the so-called Yamanaka factors; Oct4, c-Myc, Klf4 and Sox2 in the context of development, generation of iPS cells and in cancer." @default.
- W2783609156 created "2018-01-26" @default.
- W2783609156 creator A5011680761 @default.
- W2783609156 creator A5011762908 @default.
- W2783609156 creator A5023271122 @default.
- W2783609156 creator A5036763566 @default.
- W2783609156 creator A5043056699 @default.
- W2783609156 date "2018-01-01" @default.
- W2783609156 modified "2023-09-27" @default.
- W2783609156 title "Yamanaka factors and iPS cells" @default.
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