FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783620905> ?p ?o ?g. }

• W2783620905 endingPage "760" @default.
• W2783620905 startingPage "751" @default.
• W2783620905 abstract "Lung fibrosis is an ultimate consequence of bronchopulmonary dysplasia (BPD) which shows the excessive proliferation of lung fibroblasts (LFs). To find a better model for studying the role of LFs in hyperoxia-induced lung fibrosis at the cellular level, we isolated LFs from the lung tissue of hyperoxia- and normoxia-exposed rat lungs on postnatal days 7, 14 and 21 for primary culture to study their proliferative behavior. In the present study, the LF predominance was > 95% in our culture method. The LFs isolated from rats exposed to hyperoxia in vivo showed significantly greater proliferation than that from normoxia-exposed rats. Flow cytometry revealed that percentage of LFs in S and G2/M stage increased, and proportion in the G0/G1 stage declined at the same time. A greater presence of myofibroblasts in LFs isolated from rats exposed to hyperoxia compared with those exposed to normoxia. In addition, elevated collagen level, transforming growth factor-β and connective tissue growth factor protein expression in conditioned medium were also found in hyperoxia LFs. These data demonstrate that hyperoxia promotes LFs proliferation, myofibroblast transdifferentiation and collagen synthesis in a time-dependent manner. The primary culture of LFs from hyperoxia-exposed rats is a feasible method for studying the pathogenesis and treatment of lung fibrosis caused by BPD at the cellular level." @default.
• W2783620905 created "2018-01-26" @default.
• W2783620905 creator A5003853794 @default.
• W2783620905 creator A5028165423 @default.
• W2783620905 creator A5040144876 @default.
• W2783620905 creator A5041564490 @default.
• W2783620905 date "2018-01-16" @default.
• W2783620905 modified "2023-10-14" @default.
• W2783620905 title "Primary culture of lung fibroblasts from hyperoxia-exposed rats and a proliferative characteristics study" @default.
• W2783620905 cites W1993412820 @default.
• W2783620905 cites W2008892946 @default.
• W2783620905 cites W2016347199 @default.
• W2783620905 cites W2023950153 @default.
• W2783620905 cites W2051045115 @default.
• W2783620905 cites W2052088120 @default.
• W2783620905 cites W2058247847 @default.
• W2783620905 cites W2065087203 @default.
• W2783620905 cites W2069014796 @default.
• W2783620905 cites W2078387509 @default.
• W2783620905 cites W2082668280 @default.
• W2783620905 cites W2094620838 @default.
• W2783620905 cites W2106741130 @default.
• W2783620905 cites W2110644830 @default.
• W2783620905 cites W2111420507 @default.
• W2783620905 cites W2120181132 @default.
• W2783620905 cites W2123676911 @default.
• W2783620905 cites W2129012657 @default.
• W2783620905 cites W2157597415 @default.
• W2783620905 cites W2163029333 @default.
• W2783620905 cites W2216802154 @default.
• W2783620905 cites W2229113787 @default.
• W2783620905 cites W296678968 @default.
• W2783620905 cites W3020985670 @default.
• W2783620905 doi "https://doi.org/10.1007/s10616-017-0179-z" @default.
• W2783620905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5851968" @default.
• W2783620905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29340836" @default.
• W2783620905 hasPublicationYear "2018" @default.
• W2783620905 type Work @default.
• W2783620905 sameAs 2783620905 @default.
• W2783620905 citedByCount "4" @default.
• W2783620905 countsByYear W27836209052019 @default.
• W2783620905 countsByYear W27836209052020 @default.
• W2783620905 countsByYear W27836209052021 @default.
• W2783620905 countsByYear W27836209052023 @default.
• W2783620905 crossrefType "journal-article" @default.
• W2783620905 hasAuthorship W2783620905A5003853794 @default.
• W2783620905 hasAuthorship W2783620905A5028165423 @default.
• W2783620905 hasAuthorship W2783620905A5040144876 @default.
• W2783620905 hasAuthorship W2783620905A5041564490 @default.
• W2783620905 hasBestOaLocation W27836209052 @default.
• W2783620905 hasConcept C118131993 @default.
• W2783620905 hasConcept C126322002 @default.
• W2783620905 hasConcept C134018914 @default.
• W2783620905 hasConcept C142724271 @default.
• W2783620905 hasConcept C16685009 @default.
• W2783620905 hasConcept C170493617 @default.
• W2783620905 hasConcept C202751555 @default.
• W2783620905 hasConcept C2775960820 @default.
• W2783620905 hasConcept C2777714996 @default.
• W2783620905 hasConcept C2778376644 @default.
• W2783620905 hasConcept C2778721537 @default.
• W2783620905 hasConcept C2779234561 @default.
• W2783620905 hasConcept C2780559512 @default.
• W2783620905 hasConcept C2780672939 @default.
• W2783620905 hasConcept C2781244666 @default.
• W2783620905 hasConcept C518705261 @default.
• W2783620905 hasConcept C54355233 @default.
• W2783620905 hasConcept C55493867 @default.
• W2783620905 hasConcept C60870556 @default.
• W2783620905 hasConcept C71924100 @default.
• W2783620905 hasConcept C86803240 @default.
• W2783620905 hasConceptScore W2783620905C118131993 @default.
• W2783620905 hasConceptScore W2783620905C126322002 @default.
• W2783620905 hasConceptScore W2783620905C134018914 @default.
• W2783620905 hasConceptScore W2783620905C142724271 @default.
• W2783620905 hasConceptScore W2783620905C16685009 @default.
• W2783620905 hasConceptScore W2783620905C170493617 @default.
• W2783620905 hasConceptScore W2783620905C202751555 @default.
• W2783620905 hasConceptScore W2783620905C2775960820 @default.
• W2783620905 hasConceptScore W2783620905C2777714996 @default.
• W2783620905 hasConceptScore W2783620905C2778376644 @default.
• W2783620905 hasConceptScore W2783620905C2778721537 @default.
• W2783620905 hasConceptScore W2783620905C2779234561 @default.
• W2783620905 hasConceptScore W2783620905C2780559512 @default.
• W2783620905 hasConceptScore W2783620905C2780672939 @default.
• W2783620905 hasConceptScore W2783620905C2781244666 @default.
• W2783620905 hasConceptScore W2783620905C518705261 @default.
• W2783620905 hasConceptScore W2783620905C54355233 @default.
• W2783620905 hasConceptScore W2783620905C55493867 @default.
• W2783620905 hasConceptScore W2783620905C60870556 @default.
• W2783620905 hasConceptScore W2783620905C71924100 @default.
• W2783620905 hasConceptScore W2783620905C86803240 @default.
• W2783620905 hasIssue "2" @default.
• W2783620905 hasLocation W27836209051 @default.
• W2783620905 hasLocation W27836209052 @default.
• W2783620905 hasLocation W27836209053 @default.
• W2783620905 hasLocation W27836209054 @default.
• W2783620905 hasOpenAccess W2783620905 @default.

• next