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• W2783641581 startingPage "e00903" @default.
• W2783641581 abstract "The Caribbean vervet monkey (Chlorocebus aethiops sabaeus) is a potentially valuable animal model of neurodegenerative disease. However, the trajectory of aging in vervets and its relationship to human disease is incompletely understood.To characterize biomarkers associated with neurodegeneration, we measured cerebrospinal fluid (CSF) concentrations of Aβ1-40, Aβ1-42, total tau, and p-tau181 in 329 members of a multigenerational pedigree. Linkage and genome-wide association were used to elucidate a genetic contribution to these traits.Aβ1-40 concentrations were significantly correlated with age, brain total surface area, and gray matter thickness. Levels of p-tau181 were associated with cerebral volume and brain total surface area. Among the measured analytes, only CSF Aβ1-40 was heritable. No significant linkage (LOD > 3.3) was found, though suggestive linkage was highlighted on chromosomes 4 and 12. Genome-wide association identified a suggestive locus near the chromosome 4 linkage peak.Overall, these results support the vervet as a non-human primate model of amyloid-related neurodegeneration, such as Alzheimer's disease and cerebral amyloid angiopathy, and highlight Aβ1-40 and p-tau181 as potentially valuable biomarkers of these processes." @default.
• W2783641581 created "2018-01-26" @default.
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• W2783641581 date "2018-01-13" @default.
• W2783641581 modified "2023-10-13" @default.
• W2783641581 title "Neurodegenerative disease biomarkers Aβ_1-40, Aβ_1-42, tau, and p-tau₁₈₁in the vervet monkey cerebrospinal fluid: Relation to normal aging, genetic influences, and cerebral amyloid angiopathy" @default.
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• W2783641581 doi "https://doi.org/10.1002/brb3.903" @default.
• W2783641581 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5822592" @default.
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• W2783641581 hasPublicationYear "2018" @default.
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