FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783641815> ?p ?o ?g. }

• W2783641815 endingPage "1403" @default.
• W2783641815 startingPage "1392" @default.
• W2783641815 abstract "Highly glycolytic cervical cancers largely resist treatment by cisplatin and coadministered pelvic irradiation as the present standard of care. In this study, we investigated the effects of inhibiting glycolysis and thiol redox metabolism to evaluate them as alternate treatment strategies in these cancers. In a panel of multiple cervical cancer cell lines, we evaluated sensitivity to inhibition of glycolysis (2-deoxyglucose, 2-DG) with or without simultaneous inhibition of glutathione and thioredoxin metabolism (BSO/AUR). Intracellular levels of total and oxidized glutathione, thioredoxin reductase activity, and indirect measures of intracellular reactive oxygen species were compared before and after treatment. Highly radioresistant cells were the most sensitive to 2-DG, whereas intermediate radioresistant cells were sensitive to 2-DG plus BSO/AUR. In response to 2-DG/BSO/AUR treatment, we observed increased levels of intracellular oxidized glutathione, redox-sensitive dye oxidation, and decreased glucose utilization via multiple metabolic pathways including the tricarboxylic acid cycle. 2-DG/BSO/AUR treatment delayed the growth of tumors composed of intermediate radioresistant cells and effectively radiosensitized these tumors at clinically relevant radiation doses both in vitro and in vivo Overall, our results support inhibition of glycolysis and intracellular redox metabolism as an effective alternative drug strategy for the treatment of highly glycolytic and radioresistant cervical cancers.Significance: This study suggests a simple metabolic approach to strike at an apparent Achilles' heel in highly glycolytic, radioresistant forms of cervical cancers, possibly with broader applications in cancer therapy. Cancer Res; 78(6); 1392-403. ©2018 AACR." @default.
• W2783641815 created "2018-01-26" @default.
• W2783641815 creator A5006301640 @default.
• W2783641815 creator A5013011971 @default.
• W2783641815 creator A5014589918 @default.
• W2783641815 creator A5027513211 @default.
• W2783641815 creator A5044316011 @default.
• W2783641815 creator A5044619871 @default.
• W2783641815 creator A5088769540 @default.
• W2783641815 creator A5090624341 @default.
• W2783641815 date "2018-03-14" @default.
• W2783641815 modified "2023-10-16" @default.
• W2783641815 title "Radioresistant Cervical Cancers Are Sensitive to Inhibition of Glycolysis and Redox Metabolism" @default.
• W2783641815 cites W123468314 @default.
• W2783641815 cites W126188432 @default.
• W2783641815 cites W1953775887 @default.
• W2783641815 cites W1964010911 @default.
• W2783641815 cites W1964272901 @default.
• W2783641815 cites W1972350752 @default.
• W2783641815 cites W1987848909 @default.
• W2783641815 cites W1995443816 @default.
• W2783641815 cites W2001393578 @default.
• W2783641815 cites W2005727437 @default.
• W2783641815 cites W2008820074 @default.
• W2783641815 cites W2010728263 @default.
• W2783641815 cites W2011132777 @default.
• W2783641815 cites W2016535776 @default.
• W2783641815 cites W2016752484 @default.
• W2783641815 cites W2023947368 @default.
• W2783641815 cites W2026167469 @default.
• W2783641815 cites W2032533550 @default.
• W2783641815 cites W2041862829 @default.
• W2783641815 cites W2042912376 @default.
• W2783641815 cites W2054457087 @default.
• W2783641815 cites W2067979493 @default.
• W2783641815 cites W2073419672 @default.
• W2783641815 cites W2081465448 @default.
• W2783641815 cites W2084890278 @default.
• W2783641815 cites W2088414266 @default.
• W2783641815 cites W2090399856 @default.
• W2783641815 cites W2095454212 @default.
• W2783641815 cites W2102955022 @default.
• W2783641815 cites W2108428617 @default.
• W2783641815 cites W2109975763 @default.
• W2783641815 cites W2109996948 @default.
• W2783641815 cites W2116106523 @default.
• W2783641815 cites W2116651275 @default.
• W2783641815 cites W2117275311 @default.
• W2783641815 cites W2118808586 @default.
• W2783641815 cites W2124361666 @default.
• W2783641815 cites W2126701448 @default.
• W2783641815 cites W2129358321 @default.
• W2783641815 cites W2131120911 @default.
• W2783641815 cites W214449776 @default.
• W2783641815 cites W2160615487 @default.
• W2783641815 cites W2163130954 @default.
• W2783641815 cites W2522355820 @default.
• W2783641815 cites W2605566804 @default.
• W2783641815 cites W2724886670 @default.
• W2783641815 doi "https://doi.org/10.1158/0008-5472.can-17-2367" @default.
• W2783641815 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5856626" @default.
• W2783641815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29339540" @default.
• W2783641815 hasPublicationYear "2018" @default.
• W2783641815 type Work @default.
• W2783641815 sameAs 2783641815 @default.
• W2783641815 citedByCount "63" @default.
• W2783641815 countsByYear W27836418152018 @default.
• W2783641815 countsByYear W27836418152019 @default.
• W2783641815 countsByYear W27836418152020 @default.
• W2783641815 countsByYear W27836418152021 @default.
• W2783641815 countsByYear W27836418152022 @default.
• W2783641815 countsByYear W27836418152023 @default.
• W2783641815 crossrefType "journal-article" @default.
• W2783641815 hasAuthorship W2783641815A5006301640 @default.
• W2783641815 hasAuthorship W2783641815A5013011971 @default.
• W2783641815 hasAuthorship W2783641815A5014589918 @default.
• W2783641815 hasAuthorship W2783641815A5027513211 @default.
• W2783641815 hasAuthorship W2783641815A5044316011 @default.
• W2783641815 hasAuthorship W2783641815A5044619871 @default.
• W2783641815 hasAuthorship W2783641815A5088769540 @default.
• W2783641815 hasAuthorship W2783641815A5090624341 @default.
• W2783641815 hasBestOaLocation W27836418151 @default.
• W2783641815 hasConcept C121608353 @default.
• W2783641815 hasConcept C126322002 @default.
• W2783641815 hasConcept C181199279 @default.
• W2783641815 hasConcept C185592680 @default.
• W2783641815 hasConcept C20251656 @default.
• W2783641815 hasConcept C2776151105 @default.
• W2783641815 hasConcept C2777737464 @default.
• W2783641815 hasConcept C3623737 @default.
• W2783641815 hasConcept C502942594 @default.
• W2783641815 hasConcept C509974204 @default.
• W2783641815 hasConcept C538909803 @default.
• W2783641815 hasConcept C55493867 @default.
• W2783641815 hasConcept C58962609 @default.
• W2783641815 hasConcept C62231903 @default.
• W2783641815 hasConcept C71924100 @default.
• W2783641815 hasConcept C79879829 @default.

• next