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• W2783642217 endingPage "1293" @default.
• W2783642217 startingPage "1277" @default.
• W2783642217 abstract "Traumatic brain injury (TBI) in children remains a leading cause of death and disability and it remains poorly understood why children have worse outcomes and longer recover times. TBI has shown to alter cortical excitability and inhibitory drive onto excitatory neurons, yet few studies have directly examined changes to cortical interneurons. This is addressed in the present study using a clinically relevant model of severe TBI (controlled cortical impact) in interneuron cell type specific Cre-dependent mice. Mice subjected to controlled cortical impact exhibit specific loss of parvalbumin (PV) but not somatostatin immunoreactivity and cell density in the peri-injury zone. PV interneurons are primarily of a fast-spiking (FS) phenotype that persisted in the peri-injury zone but received less frequent inhibitory and stronger excitatory post-synaptic currents. The targeted loss of PV-FS interneurons appears to be distinct from previous reports in adult mice suggesting that TBI-induced pathophysiology is dependent on the age at time of impact.Paediatric traumatic brain injury (TBI) is a leading cause of death and disability in children. Traditionally, ongoing neurodevelopment and neuroplasticity have been considered to confer children with an advantage following TBI. However, recent findings indicate that the paediatric brain may be more sensitive to brain injury. Inhibitory interneurons are essential for proper cortical function and are implicated in the pathophysiology of TBI, yet few studies have directly investigated TBI-induced changes to interneurons themselves. Accordingly, in the present study, we examine how inhibitory neurons are altered following controlled cortical impact (CCI) in juvenile mice with targeted Cre-dependent fluorescence labelling of interneurons (Vgat:Cre/Ai9 and PV:Cre/Ai6). Although CCI failed to alter the number of excitatory neurons or somatostatin-expressing interneurons in the peri-injury zone, it significantly decreased the density of parvalbumin (PV) immunoreactive cells by 71%. However, PV:Cre/Ai6 mice subjected to CCI showed a lower extent of fluorescence labelled cell loss. PV interneurons are predominantly of a fast-spiking (FS) phenotype and, when recorded electrophysiologically from the peri-injury zone, exhibited intrinsic properties similar to those of control neurons. Synaptically, CCI induced a decrease in inhibitory drive onto FS interneurons combined with an increase in the strength of excitatory events. The results of the present study indicate that CCI induced both a loss of PV interneurons and an even greater loss of PV expression. This suggests caution is required when interpreting changes in PV immunoreactivity alone as direct evidence of interneuronal loss. Furthermore, in contrast to reports in adults, TBI in the paediatric brain selectively alters PV-FS interneurons, primarily resulting in a loss of interneuronal inhibition." @default.
• W2783642217 created "2018-01-26" @default.
• W2783642217 creator A5007993690 @default.
• W2783642217 creator A5008784222 @default.
• W2783642217 creator A5044677355 @default.
• W2783642217 creator A5053433800 @default.
• W2783642217 date "2018-03-05" @default.
• W2783642217 modified "2023-10-14" @default.
• W2783642217 title "Parvalbumin fast‐spiking interneurons are selectively altered by paediatric traumatic brain injury" @default.
• W2783642217 cites W1489513029 @default.
• W2783642217 cites W1503335897 @default.
• W2783642217 cites W1505732106 @default.
• W2783642217 cites W1526947019 @default.
• W2783642217 cites W1535233600 @default.
• W2783642217 cites W1572490995 @default.
• W2783642217 cites W1624401920 @default.
• W2783642217 cites W1631495829 @default.
• W2783642217 cites W1788084167 @default.
• W2783642217 cites W1895054157 @default.
• W2783642217 cites W1898373063 @default.
• W2783642217 cites W1923448222 @default.
• W2783642217 cites W1968808193 @default.
• W2783642217 cites W1970719523 @default.
• W2783642217 cites W1974434369 @default.
• W2783642217 cites W1974995288 @default.
• W2783642217 cites W1983665651 @default.
• W2783642217 cites W1992038044 @default.
• W2783642217 cites W1992910467 @default.
• W2783642217 cites W1993055859 @default.
• W2783642217 cites W1999531329 @default.
• W2783642217 cites W2001954021 @default.
• W2783642217 cites W2005388662 @default.
• W2783642217 cites W2007034511 @default.
• W2783642217 cites W2010356589 @default.
• W2783642217 cites W2013209042 @default.
• W2783642217 cites W2013522645 @default.
• W2783642217 cites W2014362456 @default.
• W2783642217 cites W2015983156 @default.
• W2783642217 cites W2018625865 @default.
• W2783642217 cites W2025603247 @default.
• W2783642217 cites W2027504242 @default.
• W2783642217 cites W2029038733 @default.
• W2783642217 cites W2035385237 @default.
• W2783642217 cites W2037553020 @default.
• W2783642217 cites W2041848975 @default.
• W2783642217 cites W2047347093 @default.
• W2783642217 cites W2047378045 @default.
• W2783642217 cites W2049610475 @default.
• W2783642217 cites W2054930781 @default.
• W2783642217 cites W2055559689 @default.
• W2783642217 cites W2056661320 @default.
• W2783642217 cites W2057881621 @default.
• W2783642217 cites W2058035812 @default.
• W2783642217 cites W2059675111 @default.
• W2783642217 cites W2061072142 @default.
• W2783642217 cites W2062450961 @default.
• W2783642217 cites W2064363302 @default.
• W2783642217 cites W2066101989 @default.
• W2783642217 cites W2070744786 @default.
• W2783642217 cites W2075377692 @default.
• W2783642217 cites W2075514099 @default.
• W2783642217 cites W2077077736 @default.
• W2783642217 cites W2084072056 @default.
• W2783642217 cites W2088475496 @default.
• W2783642217 cites W2089823661 @default.
• W2783642217 cites W2093048200 @default.
• W2783642217 cites W2096940802 @default.
• W2783642217 cites W2103592460 @default.
• W2783642217 cites W2104135721 @default.
• W2783642217 cites W2104234844 @default.
• W2783642217 cites W2107935741 @default.
• W2783642217 cites W2112297110 @default.
• W2783642217 cites W2113568840 @default.
• W2783642217 cites W2115900486 @default.
• W2783642217 cites W2116954795 @default.
• W2783642217 cites W2121531573 @default.
• W2783642217 cites W2124196462 @default.
• W2783642217 cites W2127388455 @default.
• W2783642217 cites W2131701641 @default.
• W2783642217 cites W2147871959 @default.
• W2783642217 cites W2149561999 @default.
• W2783642217 cites W2149858533 @default.
• W2783642217 cites W2151710301 @default.
• W2783642217 cites W2153738580 @default.
• W2783642217 cites W2154625706 @default.
• W2783642217 cites W2156639792 @default.
• W2783642217 cites W2156780983 @default.
• W2783642217 cites W2157874245 @default.
• W2783642217 cites W2158404383 @default.
• W2783642217 cites W2160585801 @default.
• W2783642217 cites W2160867282 @default.
• W2783642217 cites W2169604722 @default.
• W2783642217 cites W2169652092 @default.
• W2783642217 cites W2271292277 @default.
• W2783642217 cites W2308611819 @default.
• W2783642217 cites W2312429254 @default.
• W2783642217 cites W2316055407 @default.
• W2783642217 cites W2320983896 @default.

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