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• W2783642660 endingPage "1049" @default.
• W2783642660 startingPage "1037" @default.
• W2783642660 abstract "Brassinosteroids (BRs), a group of plant steroid hormones, play important roles in regulating plant development. The cytoskeleton also affects key developmental processes and a deficiency in BR biosynthesis or signaling leads to abnormal phenotypes similar to those of microtubule-defective mutants. However, how BRs regulate microtubule and cell morphology remains unknown. Here, using liquid chromatography–tandem mass spectrometry, we identified tubulin proteins that interact with Arabidopsis BRASSINOSTEROID INSENSITIVE2 (BIN2), a negative regulator of BR responses in plants. In vitro and in vivo pull-down assays confirmed that BIN2 interacts with tubulin proteins. High-speed co-sedimentation assays demonstrated that BIN2 also binds microtubules. The Arabidopsis genome also encodes two BIN2 homologs, BIN2-LIKE 1 (BIL1) and BIL2, which function redundantly with BIN2. In the bin2-3 bil1 bil2 triple mutant, cortical microtubules were more sensitive to treatment with the microtubule-disrupting drug oryzalin than in wild-type, whereas in the BIN2 gain-of-function mutant bin2-1, cortical microtubules were insensitive to oryzalin treatment. These results provide important insight into how BR regulates plant pavement cell and leaf growth by mediating the stabilization of microtubules by BIN2." @default.
• W2783642660 created "2018-01-26" @default.
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• W2783642660 date "2018-01-10" @default.
• W2783642660 modified "2023-10-11" @default.
• W2783642660 title "Brassinosteroids regulate pavement cell growth by mediating BIN2-induced microtubule stabilization" @default.
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• W2783642660 doi "https://doi.org/10.1093/jxb/erx467" @default.
• W2783642660 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6018924" @default.
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• W2783642660 hasPublicationYear "2018" @default.
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