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- W2783644122 abstract "Aim: Staphylococcus aureus is a major cause of severe hospital-acquired infections, and biofilm formation is an important part of staphylococcal pathogenesis. Therefore, developing new antimicrobial agents against both planktonic cells and biofilm of S. aureus is a major challenge. Results: Three 1,3,4-oxadiazole derivatives exhibited antimicrobial activity against seven S. aureus strains in vitro, with minimum inhibitory concentrations ranging from 4 to 32 μg/ml. At 4 × minimum inhibitory concentration, all compounds killed cells within 24 h, demonstrating bactericidal activity. In addition to their effects against planktonic cells, these compounds prevented biofilm formation in a dose-dependent manner, with inhibitory concentrations for biofilm formation ranging from 8 to 32 μg/ml. Interestingly, higher concentrations of these compounds were effective against mature biofilms and all compounds downregulated the transcription of the biofilm-related gene spa. Conclusion: We report three new 1,3,4-oxadiazole derivatives that have bactericidal activity and could provide as alternatives to combat S. aureus." @default.
- W2783644122 created "2018-01-26" @default.
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- W2783644122 date "2018-02-01" @default.
- W2783644122 modified "2023-10-18" @default.
- W2783644122 title "Antimicrobial activity of 1,3,4-oxadiazole derivatives against planktonic cells and biofilm of <i>Staphylococcus aureus</i>" @default.
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- W2783644122 doi "https://doi.org/10.4155/fmc-2017-0159" @default.
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