Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783647875> ?p ?o ?g. }
- W2783647875 endingPage "879" @default.
- W2783647875 startingPage "870" @default.
- W2783647875 abstract "Protein fibrillation is a challenging issue in medicine, causing many diseases, and an impediment to pharmaceutics and protein industry. Many chemicals, especially polyphenol compounds and aromatic small molecules, have been widely used as an effective strategy to combat protein fibril formation. Hence, understanding mechanisms of fibrillation inhibition and contributing forces in this process are significant. In this study, the inhibitory effect of paclitaxel on lysozyme fibrillation was investigated with respect to thermal and colloidal stability. Fibrillation was monitored with ThT fluorescence, circular dichroism, and AFM; paclitaxel-lysozyme interaction with isothermal titration calorimetry and docking; thermal and colloidal stability with differential scanning calorimetry and zeta-pulse, respectively. Paclitaxel inhibited lysozyme fibrillation, and interacted with lysozyme through hydrogen bonds and van der Waals' interactions. The viability of PC12 cells retrieved as a result of fibrillation inhibition by paclitaxel. Hydrophobic forces dominantly shielded the aggregation-prone region of lysozyme and suppressed the effective interactions between lysozyme monomers. Although paclitaxel did not affect lysozyme's thermal stability, it increased lysozyme's colloidal stability by either increasing the surface charge density or charge distribution on lysozyme. In conclusion, our results suggest a model for paclitaxel's inhibitory role through two complementary steps driving to off-pathway oligomer formation and attenuation of fibril formation." @default.
- W2783647875 created "2018-01-26" @default.
- W2783647875 creator A5001405352 @default.
- W2783647875 creator A5013483302 @default.
- W2783647875 creator A5024433493 @default.
- W2783647875 creator A5027517298 @default.
- W2783647875 creator A5030045562 @default.
- W2783647875 creator A5039382177 @default.
- W2783647875 creator A5039667528 @default.
- W2783647875 creator A5045577641 @default.
- W2783647875 creator A5066119888 @default.
- W2783647875 creator A5089344970 @default.
- W2783647875 date "2018-05-01" @default.
- W2783647875 modified "2023-10-16" @default.
- W2783647875 title "Paclitaxel inhibited lysozyme fibrillation by increasing colloidal stability through formation of “off-pathway” oligomers" @default.
- W2783647875 cites W1500452426 @default.
- W2783647875 cites W1553736750 @default.
- W2783647875 cites W1963947366 @default.
- W2783647875 cites W1967733770 @default.
- W2783647875 cites W1967793001 @default.
- W2783647875 cites W1968788242 @default.
- W2783647875 cites W1974038922 @default.
- W2783647875 cites W1976632394 @default.
- W2783647875 cites W1979038840 @default.
- W2783647875 cites W1979306731 @default.
- W2783647875 cites W1982054722 @default.
- W2783647875 cites W1985446400 @default.
- W2783647875 cites W1986418486 @default.
- W2783647875 cites W1995692089 @default.
- W2783647875 cites W1999019541 @default.
- W2783647875 cites W2001790200 @default.
- W2783647875 cites W2001974127 @default.
- W2783647875 cites W2010462701 @default.
- W2783647875 cites W2012363870 @default.
- W2783647875 cites W2019451328 @default.
- W2783647875 cites W2023084240 @default.
- W2783647875 cites W2028793448 @default.
- W2783647875 cites W2030092320 @default.
- W2783647875 cites W2033089660 @default.
- W2783647875 cites W2035491929 @default.
- W2783647875 cites W2037768391 @default.
- W2783647875 cites W2037866277 @default.
- W2783647875 cites W2042036635 @default.
- W2783647875 cites W2048601921 @default.
- W2783647875 cites W2048940684 @default.
- W2783647875 cites W2051361096 @default.
- W2783647875 cites W2052095709 @default.
- W2783647875 cites W2055777687 @default.
- W2783647875 cites W2056324592 @default.
- W2783647875 cites W2065002716 @default.
- W2783647875 cites W2067299834 @default.
- W2783647875 cites W2074473216 @default.
- W2783647875 cites W2074792843 @default.
- W2783647875 cites W2075705506 @default.
- W2783647875 cites W2079359574 @default.
- W2783647875 cites W2082752518 @default.
- W2783647875 cites W2083494077 @default.
- W2783647875 cites W2084076880 @default.
- W2783647875 cites W2088411503 @default.
- W2783647875 cites W2091417967 @default.
- W2783647875 cites W2093861673 @default.
- W2783647875 cites W2095242270 @default.
- W2783647875 cites W2123613399 @default.
- W2783647875 cites W2125039552 @default.
- W2783647875 cites W2129320185 @default.
- W2783647875 cites W2132629607 @default.
- W2783647875 cites W2135744465 @default.
- W2783647875 cites W2150665628 @default.
- W2783647875 cites W2153439292 @default.
- W2783647875 cites W2157218385 @default.
- W2783647875 cites W2165186407 @default.
- W2783647875 cites W2262241822 @default.
- W2783647875 cites W2324793330 @default.
- W2783647875 cites W2332520646 @default.
- W2783647875 cites W2400600528 @default.
- W2783647875 cites W2412921526 @default.
- W2783647875 cites W2509081987 @default.
- W2783647875 cites W2538837691 @default.
- W2783647875 cites W798260213 @default.
- W2783647875 doi "https://doi.org/10.1016/j.ijbiomac.2018.01.072" @default.
- W2783647875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29352977" @default.
- W2783647875 hasPublicationYear "2018" @default.
- W2783647875 type Work @default.
- W2783647875 sameAs 2783647875 @default.
- W2783647875 citedByCount "8" @default.
- W2783647875 countsByYear W27836478752019 @default.
- W2783647875 countsByYear W27836478752020 @default.
- W2783647875 countsByYear W27836478752021 @default.
- W2783647875 countsByYear W27836478752022 @default.
- W2783647875 crossrefType "journal-article" @default.
- W2783647875 hasAuthorship W2783647875A5001405352 @default.
- W2783647875 hasAuthorship W2783647875A5013483302 @default.
- W2783647875 hasAuthorship W2783647875A5024433493 @default.
- W2783647875 hasAuthorship W2783647875A5027517298 @default.
- W2783647875 hasAuthorship W2783647875A5030045562 @default.
- W2783647875 hasAuthorship W2783647875A5039382177 @default.
- W2783647875 hasAuthorship W2783647875A5039667528 @default.
- W2783647875 hasAuthorship W2783647875A5045577641 @default.