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- W2783651459 abstract "Abstract Culex pipiens mosquitoes are infected with Wolbachia ( w Pip) that cause an important diversity of cytoplasmic incompatibilities (CIs). Functional transgenic studies have implicated the cidA - cidB operon from w Pip and its homolog in w Mel in CI between infected Drosophila males and uninfected females. However, the genetic basis of the CI diversity induced by different Wolbachia strains was unknown. We show here that the remarkable diversity of CI in the C . pipiens complex is due to the presence, in all tested w Pip genomes, of several copies of the cidA - cidB operon, which undergoes diversification through recombination events. In 183 isofemale lines of C . pipiens collected worldwide, specific variations of the cidA - cidB gene repertoires are found to match crossing types. The diversification of cidA - cidB is consistent with the hypothesis of a toxin–antitoxin system in which the gene cidB co-diversifies with the gene cidA , particularly in putative domains of reciprocal interactions." @default.
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- W2783651459 date "2018-01-22" @default.
- W2783651459 modified "2023-10-05" @default.
- W2783651459 title "Culex pipiens crossing type diversity is governed by an amplified and polymorphic operon of Wolbachia" @default.
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- W2783651459 doi "https://doi.org/10.1038/s41467-017-02749-w" @default.
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