FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783669865> ?p ?o ?g. }

• W2783669865 endingPage "138" @default.
• W2783669865 startingPage "130" @default.
• W2783669865 abstract "Dynamic mechanistic modelling of cell culture is a key tool in bioprocess development to support optimisation and risk assessment. However, the approach is underutilised in the bioprocess industry due to challenges including lack of accessible tools to support a structured approach, the difficulty of realising computationally tractable (low parameter) yet realistic models, and the specialised skill sets required. We have proposed that these issues could be partly addressed by developing a parsimonious framework comprising a set of model building blocks, based on the ordinary differential equation modelling paradigm, representing common cell culture dynamics and modulation thereof. The framework is designed to avoid obvious pathological behaviours. Further, specific model instances within the framework can be simply visualised as a directed graph with vertices representing system species, dynamics and modulations, and arcs representing the interactions between them. The directed graph can be extended to describe the timing and nature of experimental interventions. A visual and intuitive route to describing models with an associated mathematical framework enables realisation in a software interface and integration with standard mathematical tools such as those for sensitivity analysis and parameter estimation. Such a framework is sufficient to represent some of the simple mechanisms underpinning bioprocesses that nonetheless lead to highly non-linear and counterintuitive outcomes. It also has a relatively low learning burden for users without formal mathematical training. The concept could be extended to include, for example, partial differential equation-based approaches to stochastic or spatially complex systems built up from a small number of parametrically parsimonious and well-behaved building blocks." @default.
• W2783669865 created "2018-01-26" @default.
• W2783669865 creator A5004807603 @default.
• W2783669865 creator A5007820461 @default.
• W2783669865 creator A5032512735 @default.
• W2783669865 creator A5044695090 @default.
• W2783669865 creator A5073549084 @default.
• W2783669865 date "2018-04-01" @default.
• W2783669865 modified "2023-09-25" @default.
• W2783669865 title "Experimentally integrated dynamic modelling for intuitive optimisation of cell based processes and manufacture" @default.
• W2783669865 cites W1547637047 @default.
• W2783669865 cites W1868738225 @default.
• W2783669865 cites W1898008112 @default.
• W2783669865 cites W1966293504 @default.
• W2783669865 cites W1968181528 @default.
• W2783669865 cites W1988540551 @default.
• W2783669865 cites W1990351024 @default.
• W2783669865 cites W2000869878 @default.
• W2783669865 cites W2014167093 @default.
• W2783669865 cites W2018568710 @default.
• W2783669865 cites W2031475240 @default.
• W2783669865 cites W2037569645 @default.
• W2783669865 cites W2042719336 @default.
• W2783669865 cites W2063159095 @default.
• W2783669865 cites W2066233746 @default.
• W2783669865 cites W2083069451 @default.
• W2783669865 cites W2098201181 @default.
• W2783669865 cites W2098722656 @default.
• W2783669865 cites W2125690493 @default.
• W2783669865 cites W2127515138 @default.
• W2783669865 cites W2129583379 @default.
• W2783669865 cites W2137077053 @default.
• W2783669865 cites W2152426716 @default.
• W2783669865 cites W2155004204 @default.
• W2783669865 cites W2162537138 @default.
• W2783669865 cites W2186508575 @default.
• W2783669865 cites W2333997296 @default.
• W2783669865 cites W2480960547 @default.
• W2783669865 cites W601171635 @default.
• W2783669865 cites W965140801 @default.
• W2783669865 cites W2147703845 @default.
• W2783669865 doi "https://doi.org/10.1016/j.bej.2018.01.012" @default.
• W2783669865 hasPublicationYear "2018" @default.
• W2783669865 type Work @default.
• W2783669865 sameAs 2783669865 @default.
• W2783669865 citedByCount "6" @default.
• W2783669865 countsByYear W27836698652018 @default.
• W2783669865 countsByYear W27836698652021 @default.
• W2783669865 countsByYear W27836698652022 @default.
• W2783669865 crossrefType "journal-article" @default.
• W2783669865 hasAuthorship W2783669865A5004807603 @default.
• W2783669865 hasAuthorship W2783669865A5007820461 @default.
• W2783669865 hasAuthorship W2783669865A5032512735 @default.
• W2783669865 hasAuthorship W2783669865A5044695090 @default.
• W2783669865 hasAuthorship W2783669865A5073549084 @default.
• W2783669865 hasBestOaLocation W27836698651 @default.
• W2783669865 hasConcept C113843644 @default.
• W2783669865 hasConcept C121332964 @default.
• W2783669865 hasConcept C126255220 @default.
• W2783669865 hasConcept C127413603 @default.
• W2783669865 hasConcept C129307140 @default.
• W2783669865 hasConcept C132525143 @default.
• W2783669865 hasConcept C134306372 @default.
• W2783669865 hasConcept C13736549 @default.
• W2783669865 hasConcept C157915830 @default.
• W2783669865 hasConcept C173608175 @default.
• W2783669865 hasConcept C21200559 @default.
• W2783669865 hasConcept C24326235 @default.
• W2783669865 hasConcept C2779462738 @default.
• W2783669865 hasConcept C33923547 @default.
• W2783669865 hasConcept C41008148 @default.
• W2783669865 hasConcept C42360764 @default.
• W2783669865 hasConcept C4916135 @default.
• W2783669865 hasConcept C51544822 @default.
• W2783669865 hasConcept C62520636 @default.
• W2783669865 hasConcept C78045399 @default.
• W2783669865 hasConcept C80444323 @default.
• W2783669865 hasConceptScore W2783669865C113843644 @default.
• W2783669865 hasConceptScore W2783669865C121332964 @default.
• W2783669865 hasConceptScore W2783669865C126255220 @default.
• W2783669865 hasConceptScore W2783669865C127413603 @default.
• W2783669865 hasConceptScore W2783669865C129307140 @default.
• W2783669865 hasConceptScore W2783669865C132525143 @default.
• W2783669865 hasConceptScore W2783669865C134306372 @default.
• W2783669865 hasConceptScore W2783669865C13736549 @default.
• W2783669865 hasConceptScore W2783669865C157915830 @default.
• W2783669865 hasConceptScore W2783669865C173608175 @default.
• W2783669865 hasConceptScore W2783669865C21200559 @default.
• W2783669865 hasConceptScore W2783669865C24326235 @default.
• W2783669865 hasConceptScore W2783669865C2779462738 @default.
• W2783669865 hasConceptScore W2783669865C33923547 @default.
• W2783669865 hasConceptScore W2783669865C41008148 @default.
• W2783669865 hasConceptScore W2783669865C42360764 @default.
• W2783669865 hasConceptScore W2783669865C4916135 @default.
• W2783669865 hasConceptScore W2783669865C51544822 @default.
• W2783669865 hasConceptScore W2783669865C62520636 @default.
• W2783669865 hasConceptScore W2783669865C78045399 @default.
• W2783669865 hasConceptScore W2783669865C80444323 @default.

• next