Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783678341> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2783678341 endingPage "1701855" @default.
- W2783678341 startingPage "1701855" @default.
- W2783678341 abstract "Baclofen is a centrally acting gamma aminobutyric acid (GABA)-B agonist, widely used for chronic spasticity in neurological disorders, available in oral and intrathecal formulations. Depending on the severity of spasticity and tolerance, standard treatment includes daily oral administration of 40–80 mg [1]. The main adverse effects reported with baclofen are sedation, sleepiness, weakness, dizziness and psychological disturbances [2]. According to the depressant effects of GABA on the central nervous system, baclofen might also induce or aggravate sleep-disordered breathing by depressing central ventilatory drive and/or increasing upper airway obstruction. A single oral low dose of baclofen did not significantly impair the apnoea–hypopnoea index (AHI) in a population with moderate obstructive sleep apnoea [3], but bolus intrathecal administration of the drug increased central sleep apnoea (CSA) in patients with severe spasticity [4]. Baclofen is associated with sleep apnoea syndrome especially the high oral doses prescribed for alcohol addiction <http://ow.ly/J5H730h4znW> The authors would like to thank the UMC that provided and gave permission to use the data analysed in the present study. Results and conclusions are those of the authors and not necessarily those of the National Centers, UMC or WHO. We thank Alison Foote (Grenoble Alps University Hospital, France) for critically editing the manuscript." @default.
- W2783678341 created "2018-01-26" @default.
- W2783678341 creator A5000196262 @default.
- W2783678341 creator A5009141174 @default.
- W2783678341 creator A5011860927 @default.
- W2783678341 creator A5025705459 @default.
- W2783678341 creator A5028541125 @default.
- W2783678341 creator A5034829050 @default.
- W2783678341 creator A5049472882 @default.
- W2783678341 creator A5068672341 @default.
- W2783678341 creator A5071764115 @default.
- W2783678341 date "2018-01-01" @default.
- W2783678341 modified "2023-10-18" @default.
- W2783678341 title "Baclofen and sleep apnoea syndrome: analysis of VigiBase, the WHO pharmacovigilance database" @default.
- W2783678341 cites W1915143997 @default.
- W2783678341 cites W1978410284 @default.
- W2783678341 cites W1982312755 @default.
- W2783678341 cites W1994052361 @default.
- W2783678341 cites W2052727969 @default.
- W2783678341 cites W2075329004 @default.
- W2783678341 cites W2079493268 @default.
- W2783678341 cites W2167186282 @default.
- W2783678341 cites W2170979974 @default.
- W2783678341 cites W2345856256 @default.
- W2783678341 cites W2518344767 @default.
- W2783678341 cites W2532407950 @default.
- W2783678341 cites W2561859210 @default.
- W2783678341 doi "https://doi.org/10.1183/13993003.01855-2017" @default.
- W2783678341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29326335" @default.
- W2783678341 hasPublicationYear "2018" @default.
- W2783678341 type Work @default.
- W2783678341 sameAs 2783678341 @default.
- W2783678341 citedByCount "13" @default.
- W2783678341 countsByYear W27836783412018 @default.
- W2783678341 countsByYear W27836783412019 @default.
- W2783678341 countsByYear W27836783412020 @default.
- W2783678341 countsByYear W27836783412021 @default.
- W2783678341 countsByYear W27836783412022 @default.
- W2783678341 crossrefType "journal-article" @default.
- W2783678341 hasAuthorship W2783678341A5000196262 @default.
- W2783678341 hasAuthorship W2783678341A5009141174 @default.
- W2783678341 hasAuthorship W2783678341A5011860927 @default.
- W2783678341 hasAuthorship W2783678341A5025705459 @default.
- W2783678341 hasAuthorship W2783678341A5028541125 @default.
- W2783678341 hasAuthorship W2783678341A5034829050 @default.
- W2783678341 hasAuthorship W2783678341A5049472882 @default.
- W2783678341 hasAuthorship W2783678341A5068672341 @default.
- W2783678341 hasAuthorship W2783678341A5071764115 @default.
- W2783678341 hasBestOaLocation W27836783411 @default.
- W2783678341 hasConcept C126322002 @default.
- W2783678341 hasConcept C170493617 @default.
- W2783678341 hasConcept C2776814716 @default.
- W2783678341 hasConcept C2778938600 @default.
- W2783678341 hasConcept C2779012798 @default.
- W2783678341 hasConcept C2781201050 @default.
- W2783678341 hasConcept C2908647359 @default.
- W2783678341 hasConcept C42219234 @default.
- W2783678341 hasConcept C71924100 @default.
- W2783678341 hasConcept C99454951 @default.
- W2783678341 hasConceptScore W2783678341C126322002 @default.
- W2783678341 hasConceptScore W2783678341C170493617 @default.
- W2783678341 hasConceptScore W2783678341C2776814716 @default.
- W2783678341 hasConceptScore W2783678341C2778938600 @default.
- W2783678341 hasConceptScore W2783678341C2779012798 @default.
- W2783678341 hasConceptScore W2783678341C2781201050 @default.
- W2783678341 hasConceptScore W2783678341C2908647359 @default.
- W2783678341 hasConceptScore W2783678341C42219234 @default.
- W2783678341 hasConceptScore W2783678341C71924100 @default.
- W2783678341 hasConceptScore W2783678341C99454951 @default.
- W2783678341 hasFunder F4320320883 @default.
- W2783678341 hasIssue "1" @default.
- W2783678341 hasLocation W27836783411 @default.
- W2783678341 hasLocation W27836783412 @default.
- W2783678341 hasLocation W27836783413 @default.
- W2783678341 hasLocation W27836783414 @default.
- W2783678341 hasLocation W27836783415 @default.
- W2783678341 hasLocation W27836783416 @default.
- W2783678341 hasLocation W27836783417 @default.
- W2783678341 hasOpenAccess W2783678341 @default.
- W2783678341 hasPrimaryLocation W27836783411 @default.
- W2783678341 hasRelatedWork W168689232 @default.
- W2783678341 hasRelatedWork W173358129 @default.
- W2783678341 hasRelatedWork W1975388421 @default.
- W2783678341 hasRelatedWork W2000721279 @default.
- W2783678341 hasRelatedWork W2045371782 @default.
- W2783678341 hasRelatedWork W2315011294 @default.
- W2783678341 hasRelatedWork W2415310649 @default.
- W2783678341 hasRelatedWork W2935698765 @default.
- W2783678341 hasRelatedWork W4327747641 @default.
- W2783678341 hasRelatedWork W4385557870 @default.
- W2783678341 hasVolume "51" @default.
- W2783678341 isParatext "false" @default.
- W2783678341 isRetracted "false" @default.
- W2783678341 magId "2783678341" @default.
- W2783678341 workType "article" @default.