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• W2783702726 abstract "Oral route of drug administration is the most common and preferred method of delivery as it is the simplest and easiest way of administering drugs. The rout offers ease of drug administration in a convenient manner and patients are more familiar with this rout. So, patient compliance and thus drug treatment is typically more effective with orally given medications.¹The tablet is most widely used dosage form existing today because of its convenience in term of self administration, compactness and ease in manufacturing. However, geriatric, paediatric and mentally ill patients experiences difficulty in swallowing conventional tablets, which is common among all age groups, especially in elderly which leads to poor patient compliance. To overcome these problem, scientists have developed innovative drug delivery system known as mouth dissolving or disintegrating tablets. This dosage forms dissolve and disintegrates in the oral cavity within minutes without need of water or chewing. This formulation is useful in administration of drug in paediatric and geriatric patients. From the present study carried out on metoclopramide HCL orodispersible tablet using by direct compression method, the following conclusion can be drawn.The total weight of MF9 batch was 150 mg contained metoclopramide HCL-6.6%, croscarmellose sodium-5.3%, microcrystalline cellulose-33.3%, aspartame-4%, magnesium stearate-1%, talc-0.6%, aerosil-0.3%, pineapple flavor-0.6%, mannitol-48%. The Prefromulation study gives the following information of optimize batch Angle of Repose-280.50‟ Bulk density-0.520, Tapped density-0.627, Compressibility Index-16.08 good to flow, Hausner ratio-1.205.Post parameter evaluation of tablets Hardness-1.96, Friability-0.788, Thickness-2.590, Weight variation-150.11±, Dispersion time-29 sec, Water absorption ratio-61.65, Disintegration time-26 sec, Content uniformity-98.93%, In-vitro drug release studies- in 3 min. If the concentration of croscarmellose sodium is increases it gives quick the disintegration and dissolution was observed. So the results give information that Disintegration time in 26 sec and dissolution in 3 min. Croscarmellose sodium is the optimize batch on basis of disintegration time and in-vitro drug release. The optimized formulation of batch MF9 gave the best in-vitro release of 99.60% in 3min in phosphate buffer pH 6.8. The release of drug followed matrix diffusion mechanism. Our objective to cost effective orodispersible tablet by direct compression quickly disperse in oral cavity and it definitely gives the fast release action for its antiemetic activity. Fast disintegration of tablets formulated in this investigation may be help in administration of metoclopramide HCL in a palatable form without water during emesis. Formulation MF9 gives the quick disintegration and better drug release. Hence it can be concluded that the formulation MF9 is a stable and effective for quick action and it is alternative to the conventional tablets." @default.
• W2783702726 created "2018-01-26" @default.
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• W2783702726 date "2012-09-01" @default.
• W2783702726 modified "2023-09-26" @default.
• W2783702726 title "Formulation and Evaluation of Orodispersible Tablets of Metoclopramide Hydrochloride." @default.
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