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- W2783703994 endingPage "952" @default.
- W2783703994 startingPage "939" @default.
- W2783703994 abstract "Synthetic polymers have enabled amorphous solid dispersions (ASDs) to emerge as an oral delivery strategy for overcoming poor drug solubility in aqueous environments. Modern ASD products noninvasively treat a range of chronic diseases (for example, hepatitis C, cystic fibrosis, and HIV). In such formulations, polymeric carriers generate and maintain drug supersaturation upon dissolution, increasing the apparent drug solubility to enhance gastrointestinal barrier absorption and oral bioavailability. In this Review, we outline several approaches in designing polymeric excipients to drive interactions with active pharmaceutical ingredients (APIs) in spray-dried ASDs, highlighting polymer–drug formulation guidelines from industrial and academic perspectives. Special attention is given to new commercial and specialized polymer design strategies that can solubilize highly hydrophobic APIs and suppress the propensity for rapid drug recrystallization. These molecularly customized excipients and hierarchical excipient assemblies are promising toward informing early-stage drug-discovery development and reformulating existing API candidates into potentially lifesaving oral medicines for our growing global population." @default.
- W2783703994 created "2018-01-26" @default.
- W2783703994 creator A5001586739 @default.
- W2783703994 creator A5042684336 @default.
- W2783703994 creator A5069824583 @default.
- W2783703994 creator A5079951206 @default.
- W2783703994 creator A5087411432 @default.
- W2783703994 date "2018-01-10" @default.
- W2783703994 modified "2023-10-18" @default.
- W2783703994 title "Advances in Polymer Design for Enhancing Oral Drug Solubility and Delivery" @default.
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