FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783704041> ?p ?o ?g. }

• W2783704041 abstract "Exposure of certain cell lines to methylcholanthrene, X-rays, or physiological growth constraint leads to preneoplastic transformation in all or most of the treated cells. After attaining confluence, a fraction in those cells progress to full transformation, as evidenced by their ability to form discrete foci distinguishable from the surrounding cells by virtue of their higher density. Transformation induced by suspension in agar, an even stronger growth-selective condition than confluence, is reminiscent of all but the final differentiated stage of a normal developmental process, epithelial-mesenchymal transition. Changes associated with transformation are not restricted to focus-forming cells, as the permissiveness for focus formation provided by confluent cells surrounding transformed foci is greater than that of nonselected cells. The neoplastic process can also be reversed in culture. Transformed cells passaged at low density in high serum revert to normal morphology and growth behavior in vitro and lose the capacity for tumor formation in vivo. We propose that transformation and its reversal are driven by a process of phenotypic selection that involves entire heterogeneous populations of cells responding to microenvironmental changes. Because of the involvement of whole cell populations, we view this process as fundamentally adaptive and epigenetic in nature." @default.
• W2783704041 created "2018-01-26" @default.
• W2783704041 creator A5016757166 @default.
• W2783704041 creator A5073309619 @default.
• W2783704041 date "2018-01-08" @default.
• W2783704041 modified "2023-09-24" @default.
• W2783704041 title "Phenotypic selection as the biological mode of epigenetic conversion and reversion in cell transformation" @default.
• W2783704041 cites W1522277376 @default.
• W2783704041 cites W1559815351 @default.
• W2783704041 cites W1602975564 @default.
• W2783704041 cites W1606308673 @default.
• W2783704041 cites W1930071516 @default.
• W2783704041 cites W1966432828 @default.
• W2783704041 cites W1966794775 @default.
• W2783704041 cites W1968807484 @default.
• W2783704041 cites W1971028473 @default.
• W2783704041 cites W1974199883 @default.
• W2783704041 cites W1994598579 @default.
• W2783704041 cites W1999778948 @default.
• W2783704041 cites W2003292748 @default.
• W2783704041 cites W2006424284 @default.
• W2783704041 cites W2015544430 @default.
• W2783704041 cites W2033210022 @default.
• W2783704041 cites W2042686811 @default.
• W2783704041 cites W2045433342 @default.
• W2783704041 cites W2047737081 @default.
• W2783704041 cites W2050217351 @default.
• W2783704041 cites W2050973237 @default.
• W2783704041 cites W2059103597 @default.
• W2783704041 cites W2067771516 @default.
• W2783704041 cites W2069652387 @default.
• W2783704041 cites W2070529781 @default.
• W2783704041 cites W2075307211 @default.
• W2783704041 cites W2075853330 @default.
• W2783704041 cites W2076583198 @default.
• W2783704041 cites W2077507145 @default.
• W2783704041 cites W2091866992 @default.
• W2783704041 cites W2165241073 @default.
• W2783704041 cites W2172046893 @default.
• W2783704041 cites W2297701691 @default.
• W2783704041 cites W2326203467 @default.
• W2783704041 cites W2463708289 @default.
• W2783704041 cites W2572707648 @default.
• W2783704041 cites W2767018165 @default.
• W2783704041 cites W4319588526 @default.
• W2783704041 cites W1593295042 @default.
• W2783704041 doi "https://doi.org/10.1073/pnas.1717299115" @default.
• W2783704041 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5789940" @default.
• W2783704041 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29311337" @default.
• W2783704041 hasPublicationYear "2018" @default.
• W2783704041 type Work @default.
• W2783704041 sameAs 2783704041 @default.
• W2783704041 citedByCount "11" @default.
• W2783704041 countsByYear W27837040412019 @default.
• W2783704041 countsByYear W27837040412020 @default.
• W2783704041 countsByYear W27837040412021 @default.
• W2783704041 countsByYear W27837040412022 @default.
• W2783704041 crossrefType "journal-article" @default.
• W2783704041 hasAuthorship W2783704041A5016757166 @default.
• W2783704041 hasAuthorship W2783704041A5073309619 @default.
• W2783704041 hasBestOaLocation W27837040411 @default.
• W2783704041 hasConcept C104317684 @default.
• W2783704041 hasConcept C127716648 @default.
• W2783704041 hasConcept C140704245 @default.
• W2783704041 hasConcept C148738053 @default.
• W2783704041 hasConcept C1491633281 @default.
• W2783704041 hasConcept C198826908 @default.
• W2783704041 hasConcept C202751555 @default.
• W2783704041 hasConcept C204241405 @default.
• W2783704041 hasConcept C2777890099 @default.
• W2783704041 hasConcept C2993273003 @default.
• W2783704041 hasConcept C31033888 @default.
• W2783704041 hasConcept C40692019 @default.
• W2783704041 hasConcept C41091548 @default.
• W2783704041 hasConcept C54355233 @default.
• W2783704041 hasConcept C555283112 @default.
• W2783704041 hasConcept C62112901 @default.
• W2783704041 hasConcept C70883133 @default.
• W2783704041 hasConcept C81885089 @default.
• W2783704041 hasConcept C85813293 @default.
• W2783704041 hasConcept C86803240 @default.
• W2783704041 hasConcept C95444343 @default.
• W2783704041 hasConceptScore W2783704041C104317684 @default.
• W2783704041 hasConceptScore W2783704041C127716648 @default.
• W2783704041 hasConceptScore W2783704041C140704245 @default.
• W2783704041 hasConceptScore W2783704041C148738053 @default.
• W2783704041 hasConceptScore W2783704041C1491633281 @default.
• W2783704041 hasConceptScore W2783704041C198826908 @default.
• W2783704041 hasConceptScore W2783704041C202751555 @default.
• W2783704041 hasConceptScore W2783704041C204241405 @default.
• W2783704041 hasConceptScore W2783704041C2777890099 @default.
• W2783704041 hasConceptScore W2783704041C2993273003 @default.
• W2783704041 hasConceptScore W2783704041C31033888 @default.
• W2783704041 hasConceptScore W2783704041C40692019 @default.
• W2783704041 hasConceptScore W2783704041C41091548 @default.
• W2783704041 hasConceptScore W2783704041C54355233 @default.
• W2783704041 hasConceptScore W2783704041C555283112 @default.
• W2783704041 hasConceptScore W2783704041C62112901 @default.
• W2783704041 hasConceptScore W2783704041C70883133 @default.
• W2783704041 hasConceptScore W2783704041C81885089 @default.

• next