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• W2783707245 abstract "The prevalence of epilepsy is higher in people with intellectual disability (ID) and increases with the degree of ID. Although life expectancy for people with ID is increasing, people with ID coexisting with epilepsy have a higher mortality rate, particularly those who had recent seizures. There have been few observational studies of the prevalence and patterns of anti-epileptic prescribing among older people with ID and epilepsy. The aim of this study was to investigate prevalence and patterns of anti-epileptic prescribing in the treatment of epilepsy in a representative population of older people with ID and epilepsy.This was an observational cross-sectional study from wave 1 (2009/2010) of Intellectual Disability Supplement to the Irish Longitudinal Study on Aging, a nationally representative sample of 753 persons with ID aged between 41 and 90 years. Participants and/or proxies recorded medicines used on a regular basis and reported doctor's diagnosis of epilepsy; medication data were available for 736 (98%). Prescribing of anti-epileptic drugs (AEDs) for epilepsy in those with a doctor's diagnosis of epilepsy (N = 205) was the primary exposure of interest for this study. Participant exposure to these AEDs was then categorised into AED monotherapy and polytherapy. Participants/carers reported seizure frequency, when epilepsy was last reviewed and which practitioner reviewed epilepsy. In addition, medications that may lower the seizure threshold that were listed in the Maudsley prescribing guidelines in psychiatry were examined.Of the 736 participants with reported medicines use, 38.9% (n = 287) were exposed to AEDs, and 30.6% (225) had a doctor's diagnosis of epilepsy. Of those with epilepsy (n = 225), 90.9% (n = 205) reported concurrent use of AEDs and epilepsy. Of these 205 participants, 50.3% (n = 103) were exposed to AED polytherapy, and 63 different polytherapy regimes were reported. The most frequently reported AEDs were valproic acid (n = 100, 48.7%), carbamazepine (n = 89, 46.3%) and lamotrigine (n = 57, 27.8%). In total, 13.7% had a concurrent psychotropic, which should be avoided in epilepsy, and 32.6% had a psychotropic where caution is required. Antipsychotics with potential epileptogenic potential accounted for 80% of these medications. Of those with AED polytherapy (n = 103), 29.5% (28) reported being seizure free for the previous 2 years.Prevalence of epilepsy was high among older people with ID, and half were exposed to two or more AEDs. Despite the use of AED therapy, over half had seizures in the previous 2 years. As the primary goals of optimal AED treatment are to achieve seizure freedom without unacceptable adverse effects, this was not achievable for many older patients with ID and epilepsy. Our findings indicated that people with ID and epilepsy were often exposed to psychotropic medications that may lower the seizure threshold. Regular review of epilepsy and medicines (including medicines that may interact with AEDs or lower the seizure threshold) by multidisciplinary teams working to agreed standards may improve quality of prescribing. Improved exchange of information and coordination of care between specialists and primary care practitioners in line with expert consensus recommendations could bring substantial benefit." @default.
• W2783707245 created "2018-01-26" @default.
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• W2783707245 date "2018-01-05" @default.
• W2783707245 modified "2023-10-13" @default.
• W2783707245 title "Prevalence and patterns of anti‐epileptic medication prescribing in the treatment of epilepsy in older adults with intellectual disabilities" @default.
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• W2783707245 cites W1967250925 @default.
• W2783707245 cites W1967657949 @default.
• W2783707245 cites W1972192997 @default.
• W2783707245 cites W1973879365 @default.
• W2783707245 cites W1979243785 @default.
• W2783707245 cites W1985208194 @default.
• W2783707245 cites W1992996433 @default.
• W2783707245 cites W1993007848 @default.
• W2783707245 cites W1993051390 @default.
• W2783707245 cites W2011326817 @default.
• W2783707245 cites W2011684756 @default.
• W2783707245 cites W2012587661 @default.
• W2783707245 cites W2015090542 @default.
• W2783707245 cites W2018808241 @default.
• W2783707245 cites W2019333928 @default.
• W2783707245 cites W2023226417 @default.
• W2783707245 cites W2025881603 @default.
• W2783707245 cites W2027711489 @default.
• W2783707245 cites W2029048550 @default.
• W2783707245 cites W2029935947 @default.
• W2783707245 cites W2033459273 @default.
• W2783707245 cites W2033614870 @default.
• W2783707245 cites W2034216073 @default.
• W2783707245 cites W2036849962 @default.
• W2783707245 cites W2041362588 @default.
• W2783707245 cites W2044976930 @default.
• W2783707245 cites W2045274557 @default.
• W2783707245 cites W2058147010 @default.
• W2783707245 cites W2060507722 @default.
• W2783707245 cites W2061680442 @default.
• W2783707245 cites W2063638938 @default.
• W2783707245 cites W2066879888 @default.
• W2783707245 cites W2068670923 @default.
• W2783707245 cites W2069751804 @default.
• W2783707245 cites W2069987842 @default.
• W2783707245 cites W2071334323 @default.
• W2783707245 cites W2073765881 @default.
• W2783707245 cites W2075411027 @default.
• W2783707245 cites W2076248499 @default.
• W2783707245 cites W2078076753 @default.
• W2783707245 cites W2080289801 @default.
• W2783707245 cites W2088679237 @default.
• W2783707245 cites W2088811688 @default.
• W2783707245 cites W2089032254 @default.
• W2783707245 cites W2093347000 @default.
• W2783707245 cites W2100946203 @default.
• W2783707245 cites W2110035222 @default.
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• W2783707245 cites W2169137352 @default.
• W2783707245 cites W2302260756 @default.
• W2783707245 cites W2340566839 @default.
• W2783707245 cites W2914249590 @default.
• W2783707245 cites W3188718543 @default.
• W2783707245 cites W4234750834 @default.
• W2783707245 cites W4296024375 @default.
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• W2783707245 doi "https://doi.org/10.1111/jir.12461" @default.
• W2783707245 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29314463" @default.
• W2783707245 hasPublicationYear "2018" @default.
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