Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783707700> ?p ?o ?g. }
- W2783707700 endingPage "44" @default.
- W2783707700 startingPage "44" @default.
- W2783707700 abstract "Skin is the largest organ in the human body, and which protects organism against unfavorable external factors e.g., chemicals, environment pollutants, allergens, microorganisms, and it plays a crucial role in maintaining general homeostasis. It is also an important target of oxidative stress due to the activity of oxygen reactive species (ROS), which are constantly generated in the fibroblasts in response to exogenous or endogenous prooxidant agents. An example of such compound with proved prooxidant activity is Doxorubicin (DOX), which is an effective anticancer agent belongs in anthracycline antibiotic group. Increasingly frequent implementation of various strategies to reduce undesirable DOX side effects was observed. Very promising results come from the combination of DOX with dietary antioxidants from the polyphenol group of compounds, such as cichoric acid (CA) in order to lower oxidative stress level. The aim of this work was to evaluate the influence of CA combined with DOX on the oxidative stress parameters in fibroblasts, which constitute the main cells in human skin. We also wanted to examine anti-apoptotic activity of CA in fibroblasts treated with selected concentrations of DOX. Results obtained from the combination of DOX with CA revealed that CA exhibits cytoprotective activity against DOX-induced damage by lowering oxidative stress level and by inhibiting apoptosis. The present finding may indicate that CA may serve as antioxidative and anti-apoptotic agent, active against DOX-induced damage." @default.
- W2783707700 created "2018-01-26" @default.
- W2783707700 creator A5000973084 @default.
- W2783707700 creator A5010234302 @default.
- W2783707700 creator A5030592762 @default.
- W2783707700 creator A5050976611 @default.
- W2783707700 creator A5055562469 @default.
- W2783707700 creator A5086113350 @default.
- W2783707700 date "2018-01-05" @default.
- W2783707700 modified "2023-10-18" @default.
- W2783707700 title "Possible Mechanisms of the Prevention of Doxorubicin Toxicity by Cichoric Acid—Antioxidant Nutrient" @default.
- W2783707700 cites W101146378 @default.
- W2783707700 cites W119916385 @default.
- W2783707700 cites W1244956254 @default.
- W2783707700 cites W1596495551 @default.
- W2783707700 cites W1903672110 @default.
- W2783707700 cites W1965746568 @default.
- W2783707700 cites W1966825452 @default.
- W2783707700 cites W1966933989 @default.
- W2783707700 cites W1970878147 @default.
- W2783707700 cites W1978585070 @default.
- W2783707700 cites W1991480458 @default.
- W2783707700 cites W2000268375 @default.
- W2783707700 cites W2001421606 @default.
- W2783707700 cites W2002821882 @default.
- W2783707700 cites W2006905940 @default.
- W2783707700 cites W2008121559 @default.
- W2783707700 cites W2020386578 @default.
- W2783707700 cites W2024638143 @default.
- W2783707700 cites W2024833586 @default.
- W2783707700 cites W2026433506 @default.
- W2783707700 cites W2028097286 @default.
- W2783707700 cites W2031752621 @default.
- W2783707700 cites W2039355845 @default.
- W2783707700 cites W2049046190 @default.
- W2783707700 cites W2049589008 @default.
- W2783707700 cites W2051215626 @default.
- W2783707700 cites W2051380719 @default.
- W2783707700 cites W2056842005 @default.
- W2783707700 cites W2061572524 @default.
- W2783707700 cites W2063788587 @default.
- W2783707700 cites W2068153312 @default.
- W2783707700 cites W2079694621 @default.
- W2783707700 cites W2080180072 @default.
- W2783707700 cites W2082990011 @default.
- W2783707700 cites W2087957280 @default.
- W2783707700 cites W2089727721 @default.
- W2783707700 cites W2098214612 @default.
- W2783707700 cites W2105015603 @default.
- W2783707700 cites W2108582141 @default.
- W2783707700 cites W2124200278 @default.
- W2783707700 cites W2128705246 @default.
- W2783707700 cites W2138206705 @default.
- W2783707700 cites W2140927361 @default.
- W2783707700 cites W2158025958 @default.
- W2783707700 cites W2177656518 @default.
- W2783707700 cites W2278194192 @default.
- W2783707700 cites W2323014882 @default.
- W2783707700 cites W2342778169 @default.
- W2783707700 cites W2410456058 @default.
- W2783707700 cites W2461988406 @default.
- W2783707700 cites W2565551780 @default.
- W2783707700 cites W2599142662 @default.
- W2783707700 cites W2669602412 @default.
- W2783707700 cites W2726190435 @default.
- W2783707700 cites W2745590142 @default.
- W2783707700 doi "https://doi.org/10.3390/nu10010044" @default.
- W2783707700 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5793272" @default.
- W2783707700 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29303987" @default.
- W2783707700 hasPublicationYear "2018" @default.
- W2783707700 type Work @default.
- W2783707700 sameAs 2783707700 @default.
- W2783707700 citedByCount "34" @default.
- W2783707700 countsByYear W27837077002018 @default.
- W2783707700 countsByYear W27837077002019 @default.
- W2783707700 countsByYear W27837077002020 @default.
- W2783707700 countsByYear W27837077002021 @default.
- W2783707700 countsByYear W27837077002022 @default.
- W2783707700 countsByYear W27837077002023 @default.
- W2783707700 crossrefType "journal-article" @default.
- W2783707700 hasAuthorship W2783707700A5000973084 @default.
- W2783707700 hasAuthorship W2783707700A5010234302 @default.
- W2783707700 hasAuthorship W2783707700A5030592762 @default.
- W2783707700 hasAuthorship W2783707700A5050976611 @default.
- W2783707700 hasAuthorship W2783707700A5055562469 @default.
- W2783707700 hasAuthorship W2783707700A5086113350 @default.
- W2783707700 hasBestOaLocation W27837077001 @default.
- W2783707700 hasConcept C185592680 @default.
- W2783707700 hasConcept C190283241 @default.
- W2783707700 hasConcept C2776151105 @default.
- W2783707700 hasConcept C2776694085 @default.
- W2783707700 hasConcept C2778004101 @default.
- W2783707700 hasConcept C2781303535 @default.
- W2783707700 hasConcept C48349386 @default.
- W2783707700 hasConcept C54355233 @default.
- W2783707700 hasConcept C55493867 @default.
- W2783707700 hasConcept C70899900 @default.
- W2783707700 hasConcept C86803240 @default.