Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783750102> ?p ?o ?g. }
- W2783750102 abstract "Abstract Therapeutic antibodies (e.g., trastuzumab, TRA) against human epidermal growth factor receptor 2 (HER2)‐positive breast cancers have shown benefits in controlling primary tumors, yet are ineffective against brain metastases due to their inability to cross the blood‐brain barrier (BBB). A novel hybrid nanoconstruct system is designed to deliver trastuzumab to brain metastasis of HER2‐positive breast cancer via a two‐step sequential targeting approach. Self‐assembly of a polysorbate 80 (PS 80)‐containing polymer, lipid, and polymer‐conjugated TRA forms hybrid nanoconstructs (TRA–terpolymer nanoparticles (TPN)) with high encapsulation efficiency and bioactivity. The PS 80 moiety enables the first‐step targeting and receptor‐mediated trancytosis across BBB is demonstrated in vitro with a 3D human BBB model in healthy and brain tumor‐bearing mice. The subsequent partial dissociation of the nanoconstructs exposes the encapsulated TRA for the second‐step targeting to HER2‐positive cancer cells in the brain. Intravenously injected TRA–TPN delivers 50‐fold TRA compared to free TRA to the brain metastasis of HER2‐positive breast cancer. Treatment with TRA–TPN increases tumor cell apoptosis by 4‐fold, inhibits tumor growth by 43‐fold, and prolongs median survival by >1.3‐fold compared to free TRA, without causing noticeable organ toxicity. These findings suggest the two‐step targeted nanoconstruct system is promising for shuttling therapeutic antibodies to treat central nervous system diseases." @default.
- W2783750102 created "2018-01-26" @default.
- W2783750102 creator A5004445832 @default.
- W2783750102 creator A5008969548 @default.
- W2783750102 creator A5029032414 @default.
- W2783750102 creator A5034010784 @default.
- W2783750102 creator A5044905482 @default.
- W2783750102 creator A5049058098 @default.
- W2783750102 creator A5062977227 @default.
- W2783750102 creator A5063182563 @default.
- W2783750102 creator A5080235829 @default.
- W2783750102 date "2018-01-08" @default.
- W2783750102 modified "2023-10-14" @default.
- W2783750102 title "Two‐Step Targeted Hybrid Nanoconstructs Increase Brain Penetration and Efficacy of the Therapeutic Antibody Trastuzumab against Brain Metastasis of HER2‐Positive Breast Cancer" @default.
- W2783750102 cites W133175338 @default.
- W2783750102 cites W1553061387 @default.
- W2783750102 cites W1975495109 @default.
- W2783750102 cites W1979780600 @default.
- W2783750102 cites W1995525906 @default.
- W2783750102 cites W1996719014 @default.
- W2783750102 cites W2003736464 @default.
- W2783750102 cites W2004565731 @default.
- W2783750102 cites W2009244092 @default.
- W2783750102 cites W2015578801 @default.
- W2783750102 cites W2017668300 @default.
- W2783750102 cites W2017925961 @default.
- W2783750102 cites W2018361874 @default.
- W2783750102 cites W2023243792 @default.
- W2783750102 cites W2025061302 @default.
- W2783750102 cites W2025919785 @default.
- W2783750102 cites W2028383367 @default.
- W2783750102 cites W2032760352 @default.
- W2783750102 cites W2040935952 @default.
- W2783750102 cites W2043228552 @default.
- W2783750102 cites W2044243833 @default.
- W2783750102 cites W2055810294 @default.
- W2783750102 cites W2058586537 @default.
- W2783750102 cites W2074343604 @default.
- W2783750102 cites W2077128382 @default.
- W2783750102 cites W2089028453 @default.
- W2783750102 cites W2089586599 @default.
- W2783750102 cites W2098775844 @default.
- W2783750102 cites W2108615682 @default.
- W2783750102 cites W2109699895 @default.
- W2783750102 cites W2112007587 @default.
- W2783750102 cites W2112326782 @default.
- W2783750102 cites W2115847479 @default.
- W2783750102 cites W2116728374 @default.
- W2783750102 cites W2116760308 @default.
- W2783750102 cites W2126799977 @default.
- W2783750102 cites W2130735457 @default.
- W2783750102 cites W2132974552 @default.
- W2783750102 cites W2137159389 @default.
- W2783750102 cites W2138037217 @default.
- W2783750102 cites W2139085578 @default.
- W2783750102 cites W214589945 @default.
- W2783750102 cites W2147810684 @default.
- W2783750102 cites W2152471217 @default.
- W2783750102 cites W2154290856 @default.
- W2783750102 cites W2162676548 @default.
- W2783750102 cites W2163148038 @default.
- W2783750102 cites W2166153750 @default.
- W2783750102 cites W2178539375 @default.
- W2783750102 cites W2194925901 @default.
- W2783750102 cites W2253028130 @default.
- W2783750102 cites W2261146704 @default.
- W2783750102 cites W2281904128 @default.
- W2783750102 cites W2342538795 @default.
- W2783750102 cites W2395300225 @default.
- W2783750102 cites W2396042072 @default.
- W2783750102 cites W2414909242 @default.
- W2783750102 cites W2555156914 @default.
- W2783750102 cites W2561694948 @default.
- W2783750102 cites W2597045666 @default.
- W2783750102 cites W2726008343 @default.
- W2783750102 cites W2746191133 @default.
- W2783750102 cites W4239989216 @default.
- W2783750102 doi "https://doi.org/10.1002/adfm.201705668" @default.
- W2783750102 hasPublicationYear "2018" @default.
- W2783750102 type Work @default.
- W2783750102 sameAs 2783750102 @default.
- W2783750102 citedByCount "28" @default.
- W2783750102 countsByYear W27837501022018 @default.
- W2783750102 countsByYear W27837501022019 @default.
- W2783750102 countsByYear W27837501022020 @default.
- W2783750102 countsByYear W27837501022021 @default.
- W2783750102 countsByYear W27837501022022 @default.
- W2783750102 countsByYear W27837501022023 @default.
- W2783750102 crossrefType "journal-article" @default.
- W2783750102 hasAuthorship W2783750102A5004445832 @default.
- W2783750102 hasAuthorship W2783750102A5008969548 @default.
- W2783750102 hasAuthorship W2783750102A5029032414 @default.
- W2783750102 hasAuthorship W2783750102A5034010784 @default.
- W2783750102 hasAuthorship W2783750102A5044905482 @default.
- W2783750102 hasAuthorship W2783750102A5049058098 @default.
- W2783750102 hasAuthorship W2783750102A5062977227 @default.
- W2783750102 hasAuthorship W2783750102A5063182563 @default.
- W2783750102 hasAuthorship W2783750102A5080235829 @default.
- W2783750102 hasConcept C121608353 @default.
- W2783750102 hasConcept C126322002 @default.