Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783751372> ?p ?o ?g. }
- W2783751372 endingPage "1254" @default.
- W2783751372 startingPage "1245" @default.
- W2783751372 abstract "In this study, we reported the hyaluronic acid (HA) on supramolecular structure of Pluronic F-127 (PLF-127) and/or Pluronic F-108 (PLF-127) hydrogels, as well as their effects on release mechanisms, looking forward their application as lidocaine (LDC) drug-delivery systems in arthroplastic surgeries. We have studied the HA-micelle interaction using Dynamic Light Scattering (DLS), the micellization and sol-gel transition processes by Differential Scanning Calorimetry (DSC) and Rheology., of PL-based hydrogels and. The presence of HA provided the formation of larger micellar dimensions from ~26.0 to 42.4 nm. The incorporation of HA did not change the micellization temperatures and stabilized hydrogels rheological properties (G′ > G″), showing no interference on PL-thermoreversible properties. Small-Angle-X-ray Scattering (SAXS) patterns revealed that HA incorporation effects were pronounced for PLF-127 and PLF-108 systems, showing transitions from lamellar to hexagonal phase organization (HA-PLF-127) and structural changes from cubic to gyroid and/or cubic to lamellar. The HA insertion effects were also observed on drug release profiles, since lower LDC release constants (Krel = 0.24–0.41 mM·h−1) were observed for HA-PLF-127, that presented a hexagonal phase organization. Furthermore, the HA-PL systems presented reduced in vitro cytotoxic effects, pointed out their tendency to self-assembly and possible application as drug delivery systems." @default.
- W2783751372 created "2018-01-26" @default.
- W2783751372 creator A5000468508 @default.
- W2783751372 creator A5020236394 @default.
- W2783751372 creator A5032391651 @default.
- W2783751372 creator A5042607942 @default.
- W2783751372 creator A5077139192 @default.
- W2783751372 creator A5083552438 @default.
- W2783751372 date "2018-05-01" @default.
- W2783751372 modified "2023-10-16" @default.
- W2783751372 title "Hyaluronic acid in Pluronic F-127/F-108 hydrogels for postoperative pain in arthroplasties: Influence on physico-chemical properties and structural requirements for sustained drug-release" @default.
- W2783751372 cites W1601790450 @default.
- W2783751372 cites W1638472847 @default.
- W2783751372 cites W1968974073 @default.
- W2783751372 cites W1969604041 @default.
- W2783751372 cites W1976144807 @default.
- W2783751372 cites W1991874712 @default.
- W2783751372 cites W1995488266 @default.
- W2783751372 cites W1995654243 @default.
- W2783751372 cites W1996262004 @default.
- W2783751372 cites W2019304442 @default.
- W2783751372 cites W2030599839 @default.
- W2783751372 cites W2038760102 @default.
- W2783751372 cites W2042154857 @default.
- W2783751372 cites W2054087659 @default.
- W2783751372 cites W2054609339 @default.
- W2783751372 cites W2055036254 @default.
- W2783751372 cites W2061020756 @default.
- W2783751372 cites W2062211713 @default.
- W2783751372 cites W2069487993 @default.
- W2783751372 cites W2076670186 @default.
- W2783751372 cites W2139580016 @default.
- W2783751372 cites W2153519151 @default.
- W2783751372 cites W2166674362 @default.
- W2783751372 cites W2167792025 @default.
- W2783751372 cites W2185421216 @default.
- W2783751372 cites W2315158026 @default.
- W2783751372 cites W2408569191 @default.
- W2783751372 cites W2551331867 @default.
- W2783751372 cites W2638093284 @default.
- W2783751372 cites W4243642179 @default.
- W2783751372 cites W2089281961 @default.
- W2783751372 doi "https://doi.org/10.1016/j.ijbiomac.2018.01.064" @default.
- W2783751372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29339288" @default.
- W2783751372 hasPublicationYear "2018" @default.
- W2783751372 type Work @default.
- W2783751372 sameAs 2783751372 @default.
- W2783751372 citedByCount "51" @default.
- W2783751372 countsByYear W27837513722019 @default.
- W2783751372 countsByYear W27837513722020 @default.
- W2783751372 countsByYear W27837513722021 @default.
- W2783751372 countsByYear W27837513722022 @default.
- W2783751372 countsByYear W27837513722023 @default.
- W2783751372 crossrefType "journal-article" @default.
- W2783751372 hasAuthorship W2783751372A5000468508 @default.
- W2783751372 hasAuthorship W2783751372A5020236394 @default.
- W2783751372 hasAuthorship W2783751372A5032391651 @default.
- W2783751372 hasAuthorship W2783751372A5042607942 @default.
- W2783751372 hasAuthorship W2783751372A5077139192 @default.
- W2783751372 hasAuthorship W2783751372A5083552438 @default.
- W2783751372 hasConcept C101335993 @default.
- W2783751372 hasConcept C108586683 @default.
- W2783751372 hasConcept C11268172 @default.
- W2783751372 hasConcept C120665830 @default.
- W2783751372 hasConcept C121332964 @default.
- W2783751372 hasConcept C127413603 @default.
- W2783751372 hasConcept C131888329 @default.
- W2783751372 hasConcept C15920480 @default.
- W2783751372 hasConcept C177418412 @default.
- W2783751372 hasConcept C178790620 @default.
- W2783751372 hasConcept C184651966 @default.
- W2783751372 hasConcept C185592680 @default.
- W2783751372 hasConcept C188027245 @default.
- W2783751372 hasConcept C191486275 @default.
- W2783751372 hasConcept C192562407 @default.
- W2783751372 hasConcept C2777529286 @default.
- W2783751372 hasConcept C2779820397 @default.
- W2783751372 hasConcept C2780134926 @default.
- W2783751372 hasConcept C39519442 @default.
- W2783751372 hasConcept C42360764 @default.
- W2783751372 hasConcept C44280652 @default.
- W2783751372 hasConcept C521977710 @default.
- W2783751372 hasConcept C54355233 @default.
- W2783751372 hasConcept C77851909 @default.
- W2783751372 hasConcept C8010536 @default.
- W2783751372 hasConcept C86803240 @default.
- W2783751372 hasConcept C97355855 @default.
- W2783751372 hasConceptScore W2783751372C101335993 @default.
- W2783751372 hasConceptScore W2783751372C108586683 @default.
- W2783751372 hasConceptScore W2783751372C11268172 @default.
- W2783751372 hasConceptScore W2783751372C120665830 @default.
- W2783751372 hasConceptScore W2783751372C121332964 @default.
- W2783751372 hasConceptScore W2783751372C127413603 @default.
- W2783751372 hasConceptScore W2783751372C131888329 @default.
- W2783751372 hasConceptScore W2783751372C15920480 @default.
- W2783751372 hasConceptScore W2783751372C177418412 @default.
- W2783751372 hasConceptScore W2783751372C178790620 @default.
- W2783751372 hasConceptScore W2783751372C184651966 @default.