Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783752003> ?p ?o ?g. }
- W2783752003 abstract "Abstract The ubiquitously expressed RNA-binding proteins Roquin-1 and Roquin-2 are essential for appropriate immune cell function and postnatal survival of mice. Roquin proteins repress target mRNAs by recognizing secondary structures in their 3′ - UTRs and by inducing mRNA decay. However, it is unknown if other cellular proteins contribute to target control. To identify cofactors of Roquin, we used RNA interference to screen ~1500 genes involved in RNA-binding or mRNA degradation, and identified NUFIP2 as a cofactor of Roquin-induced mRNA decay. NUFIP2 binds directly and with high affinity to Roquin, which stabilizes NUFIP2 in cells. Post-transcriptional repression of human ICOS by endogenous Roquin proteins requires two neighboring non-canonical stem-loops in the ICOS 3′-UTR. This unconventional cis -element as well as another tandem loop known to confer Roquin-mediated regulation of the Ox40 3′-UTR, are bound cooperatively by Roquin and NUFIP2. NUFIP2 therefore emerges as a cofactor that contributes to mRNA target recognition by Roquin." @default.
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- W2783752003 date "2018-01-19" @default.
- W2783752003 modified "2023-09-27" @default.
- W2783752003 title "Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA" @default.
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- W2783752003 doi "https://doi.org/10.1038/s41467-017-02582-1" @default.
- W2783752003 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5775257" @default.
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