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- W2783753107 abstract "Chromium(III) chloride mediates DNA-DNA cross-linking. Some chromium complexes promote programmed cell death in specific ligand environment through binding to DNA. One strategy that can be supposed for reduction of Cr3+ binding affinity to DNA is using curcumin as a chelator. In the current study, the [Cr(Curcumin)(EtOH)2](NO3)2 (CCC) was synthesized and characterized by UV/Vis, FT-IR, CHN and spectrophotometric titration techniques. The mole ratio plot revealed a 1:1 complex between Cr3+ and curcumin in solution. Binding interaction of this complex with calf thymus-DNA (CT-DNA) was investigated using UV/Vis, circular dichroism (CD), FT-IR and cyclic voltammetry. The intrinsic binding constants of CCC with DNA, measured by UV/Vis and cyclic voltammetry, were 1.60 × 105 and 1.13 × 105, respectively. The thermodynamic studies showed that the reaction is enthalpy and entropy favoured. CD analysis revealed that only Λ-CCC interacts with DNA and Δ-CCC form has no tendency towards DNA. Based on FT-IR studies, it was understood that CCC interacts with DNA via minor groove binding. The docking simulation was carried out for finding the binding mode of CCC to DNA, too. All of data demonstrated that the curcumin significantly reduced the affinity of Cr3+ to the DNA and the form of Δ-CCC has no interaction with DNA." @default.
- W2783753107 created "2018-01-26" @default.
- W2783753107 creator A5018783585 @default.
- W2783753107 creator A5036491342 @default.
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- W2783753107 date "2018-01-02" @default.
- W2783753107 modified "2023-09-26" @default.
- W2783753107 title "The evaluation of Cr-curcumin-DNA complexation by experimental and theoretical approaches" @default.
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- W2783753107 doi "https://doi.org/10.1080/15257770.2017.1414241" @default.
- W2783753107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29336691" @default.
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