Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783757852> ?p ?o ?g. }
- W2783757852 endingPage "869" @default.
- W2783757852 startingPage "829" @default.
- W2783757852 abstract "Gene-based therapy is one of essential therapeutic strategies for precision medicine through targeting specific genes in specific cells of target tissues. However, there still exist many problems that need to be solved, such as safety, stability, selectivity, delivery, as well as immunity. Currently, the key challenges of gene-based therapy for clinical potential applications are the safe and effective nucleic acid drugs as well as their safe and efficient gene delivery systems. In this review, we first focus on current nucleic acid drugs and their formulation in clinical trials and on the market, including antisense oligonucleotide, siRNA, aptamer, and plasmid nucleic acid drugs. Subsequently, we summarize different chemical modifications of nucleic acid drugs as well as their delivery systems for gene-based therapeutics in vivo based on nucleic acid chemistry and nanotechnology methods." @default.
- W2783757852 created "2018-01-26" @default.
- W2783757852 creator A5034606481 @default.
- W2783757852 creator A5060533134 @default.
- W2783757852 creator A5089469220 @default.
- W2783757852 date "2018-01-05" @default.
- W2783757852 modified "2023-10-14" @default.
- W2783757852 title "Chemical modifications of nucleic acid drugs and their delivery systems for gene-based therapy" @default.
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