Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783758290> ?p ?o ?g. }
- W2783758290 abstract "Abstract Tomato leaf curl Palampur virus (ToLCPalV) is a whitefly-transmitted, bipartite begomovirus. Here, we demonstrated that ectopic expression of AV2 from a Potato virus X (PVX)-based vector accelerated systemic necrosis and reactive oxygen species (ROS) accumulation in Nicotiana benthamiana . Furthermore, 10 amino acids from N-terminal region of AV2 were found to be associated with the systemic necrosis symptom/phenotype. Mutational studies of ToLCPalV infectious clones lacking the AV2 revealed that AV2 is essential for the systemic movement of DNA-A, symptom severity and viral DNA accumulation. In a yeast two-hybrid assay, Catalase2 (Cat2) was found to associate with AV2 protein. Further, silencing of Cat2 resulted in appearance of necrotic lesions on N. benthamiana and these plants were highly susceptible to ToLCPalV infection in comparison to control plants. Infection ToLCPalV on Solanum lycopersicum resulted in downregulation of Cat2 transcripts, followed by accumulation of ROS and stress marker transcripts. The AV2 protein also suppressed virus-induced gene silencing (VIGS) of the Phytoene desaturase ( PDS ) gene. Our results show that AV2 is essential for the pathogenicity, systemic movement and suppression of gene silencing in the host. Altogether, our findings suggest that interactions between AV2 and Cat2 might play a crucial role in the establishment of ToLCPalV infection." @default.
- W2783758290 created "2018-01-26" @default.
- W2783758290 creator A5001716874 @default.
- W2783758290 creator A5023128951 @default.
- W2783758290 creator A5033692318 @default.
- W2783758290 creator A5034902709 @default.
- W2783758290 creator A5087385312 @default.
- W2783758290 date "2018-01-19" @default.
- W2783758290 modified "2023-10-12" @default.
- W2783758290 title "AV2 protein of tomato leaf curl Palampur virus promotes systemic necrosis in Nicotiana benthamiana and interacts with host Catalase2" @default.
- W2783758290 cites W113453375 @default.
- W2783758290 cites W1527321517 @default.
- W2783758290 cites W1579213397 @default.
- W2783758290 cites W1594526056 @default.
- W2783758290 cites W1971373251 @default.
- W2783758290 cites W1973328229 @default.
- W2783758290 cites W1978362157 @default.
- W2783758290 cites W1980610394 @default.
- W2783758290 cites W1984374025 @default.
- W2783758290 cites W1987664369 @default.
- W2783758290 cites W1997442274 @default.
- W2783758290 cites W1998129679 @default.
- W2783758290 cites W2009344496 @default.
- W2783758290 cites W2016635789 @default.
- W2783758290 cites W2017681723 @default.
- W2783758290 cites W2027396011 @default.
- W2783758290 cites W2028210885 @default.
- W2783758290 cites W2032746290 @default.
- W2783758290 cites W2035407920 @default.
- W2783758290 cites W2039508982 @default.
- W2783758290 cites W2043732571 @default.
- W2783758290 cites W2049531408 @default.
- W2783758290 cites W2051219024 @default.
- W2783758290 cites W2051652482 @default.
- W2783758290 cites W2051866530 @default.
- W2783758290 cites W2054776385 @default.
- W2783758290 cites W2056261250 @default.
- W2783758290 cites W2059836096 @default.
- W2783758290 cites W2063053724 @default.
- W2783758290 cites W2068730569 @default.
- W2783758290 cites W2074473216 @default.
- W2783758290 cites W2079826670 @default.
- W2783758290 cites W2080243934 @default.
- W2783758290 cites W2082085925 @default.
- W2783758290 cites W2082720258 @default.
- W2783758290 cites W2084244231 @default.
- W2783758290 cites W2084447633 @default.
- W2783758290 cites W2090216114 @default.
- W2783758290 cites W2095105254 @default.
- W2783758290 cites W2096751405 @default.
- W2783758290 cites W2099655440 @default.
- W2783758290 cites W2101688596 @default.
- W2783758290 cites W2105441860 @default.
- W2783758290 cites W2105537485 @default.
- W2783758290 cites W2106210646 @default.
- W2783758290 cites W2107277218 @default.
- W2783758290 cites W2112298897 @default.
- W2783758290 cites W2118906275 @default.
- W2783758290 cites W2120470126 @default.
- W2783758290 cites W2121726080 @default.
- W2783758290 cites W2124338693 @default.
- W2783758290 cites W2147663934 @default.
- W2783758290 cites W2153819056 @default.
- W2783758290 cites W2154140763 @default.
- W2783758290 cites W2154831678 @default.
- W2783758290 cites W2155041799 @default.
- W2783758290 cites W2155201844 @default.
- W2783758290 cites W2156027339 @default.
- W2783758290 cites W2159746639 @default.
- W2783758290 cites W2164671653 @default.
- W2783758290 cites W2171520124 @default.
- W2783758290 cites W2171917686 @default.
- W2783758290 cites W2178753623 @default.
- W2783758290 cites W2192080449 @default.
- W2783758290 cites W2256869781 @default.
- W2783758290 cites W2261964703 @default.
- W2783758290 cites W2291651280 @default.
- W2783758290 cites W2407295961 @default.
- W2783758290 cites W2512314654 @default.
- W2783758290 cites W2521900965 @default.
- W2783758290 cites W2595220198 @default.
- W2783758290 cites W2768428576 @default.
- W2783758290 cites W4213391533 @default.
- W2783758290 cites W4232832709 @default.
- W2783758290 cites W4322702682 @default.
- W2783758290 doi "https://doi.org/10.1038/s41598-018-19292-3" @default.
- W2783758290 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5775426" @default.
- W2783758290 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29352245" @default.
- W2783758290 hasPublicationYear "2018" @default.
- W2783758290 type Work @default.
- W2783758290 sameAs 2783758290 @default.
- W2783758290 citedByCount "23" @default.
- W2783758290 countsByYear W27837582902020 @default.
- W2783758290 countsByYear W27837582902021 @default.
- W2783758290 countsByYear W27837582902022 @default.
- W2783758290 countsByYear W27837582902023 @default.
- W2783758290 crossrefType "journal-article" @default.
- W2783758290 hasAuthorship W2783758290A5001716874 @default.
- W2783758290 hasAuthorship W2783758290A5023128951 @default.
- W2783758290 hasAuthorship W2783758290A5033692318 @default.